| Full name: POU class 6 homeobox 1 | Alias Symbol: BRN5|MPOU|TCFB1 | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 5463 | HGNC ID: HGNC:9224 | Ensembl Gene: ENSG00000184271 | OMIM ID: 618043 |
| Drug and gene relationship at DGIdb | |||
Expression of POU6F1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POU6F1 | 5463 | 205878_at | -0.4792 | 0.2909 | |
| GSE20347 | POU6F1 | 5463 | 216332_at | -0.1199 | 0.1505 | |
| GSE23400 | POU6F1 | 5463 | 216330_s_at | -0.2141 | 0.0000 | |
| GSE26886 | POU6F1 | 5463 | 216332_at | -0.1390 | 0.2799 | |
| GSE29001 | POU6F1 | 5463 | 216332_at | -0.1848 | 0.2507 | |
| GSE38129 | POU6F1 | 5463 | 216332_at | -0.3448 | 0.0001 | |
| GSE45670 | POU6F1 | 5463 | 216332_at | -0.0716 | 0.4067 | |
| GSE63941 | POU6F1 | 5463 | 216332_at | 0.2601 | 0.0658 | |
| GSE77861 | POU6F1 | 5463 | 216332_at | -0.0992 | 0.4981 | |
| GSE97050 | POU6F1 | 5463 | A_23_P329375 | -0.4612 | 0.3370 | |
| SRP007169 | POU6F1 | 5463 | RNAseq | 0.1835 | 0.7434 | |
| SRP064894 | POU6F1 | 5463 | RNAseq | -0.1929 | 0.2859 | |
| SRP133303 | POU6F1 | 5463 | RNAseq | -0.3882 | 0.0405 | |
| SRP159526 | POU6F1 | 5463 | RNAseq | -0.4105 | 0.1008 | |
| SRP193095 | POU6F1 | 5463 | RNAseq | 0.1125 | 0.4170 | |
| SRP219564 | POU6F1 | 5463 | RNAseq | -0.2219 | 0.6361 | |
| TCGA | POU6F1 | 5463 | RNAseq | -0.5876 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POU6F1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of POU6F1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POU6F1 | 5463 | 8 | 1 | 21 | |
| GSE20123 | POU6F1 | 5463 | 8 | 1 | 21 | |
| GSE43470 | POU6F1 | 5463 | 3 | 0 | 40 | |
| GSE46452 | POU6F1 | 5463 | 8 | 1 | 50 | |
| GSE47630 | POU6F1 | 5463 | 11 | 2 | 27 | |
| GSE54993 | POU6F1 | 5463 | 0 | 5 | 65 | |
| GSE54994 | POU6F1 | 5463 | 3 | 2 | 48 | |
| GSE60625 | POU6F1 | 5463 | 0 | 0 | 11 | |
| GSE74703 | POU6F1 | 5463 | 3 | 0 | 33 | |
| GSE74704 | POU6F1 | 5463 | 5 | 1 | 14 | |
| TCGA | POU6F1 | 5463 | 14 | 11 | 71 |
Total number of gains: 63; Total number of losses: 24; Total Number of normals: 401.
Somatic mutations of POU6F1:
Generating mutation plots.
Highly correlated genes for POU6F1:
Showing top 20/981 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POU6F1 | GBA2 | 0.810909 | 3 | 0 | 3 |
| POU6F1 | C9orf47 | 0.803349 | 3 | 0 | 3 |
| POU6F1 | CHCHD10 | 0.78381 | 3 | 0 | 3 |
| POU6F1 | KLHL29 | 0.773758 | 3 | 0 | 3 |
| POU6F1 | NDUFAF3 | 0.766254 | 3 | 0 | 3 |
| POU6F1 | TMEM114 | 0.751362 | 4 | 0 | 4 |
| POU6F1 | C1QTNF7 | 0.741593 | 3 | 0 | 3 |
| POU6F1 | WSCD2 | 0.728939 | 6 | 0 | 6 |
| POU6F1 | OPRM1 | 0.72705 | 3 | 0 | 3 |
| POU6F1 | STAC | 0.721644 | 3 | 0 | 3 |
| POU6F1 | SSC5D | 0.720214 | 3 | 0 | 3 |
| POU6F1 | RILP | 0.717065 | 3 | 0 | 3 |
| POU6F1 | KIF5C | 0.707138 | 4 | 0 | 4 |
| POU6F1 | GABRR2 | 0.703532 | 5 | 0 | 5 |
| POU6F1 | RXRG | 0.7021 | 6 | 0 | 5 |
| POU6F1 | GJC2 | 0.698121 | 8 | 0 | 8 |
| POU6F1 | NHSL2 | 0.697653 | 4 | 0 | 3 |
| POU6F1 | NUDT7 | 0.695285 | 4 | 0 | 3 |
| POU6F1 | STK33 | 0.693433 | 3 | 0 | 3 |
| POU6F1 | AKAP6 | 0.692103 | 7 | 0 | 6 |
For details and further investigation, click here
