| Full name: coiled-coil domain containing 59 | Alias Symbol: HSPC128|TAP26|BR22 | ||
| Type: protein-coding gene | Cytoband: 12q21.31 | ||
| Entrez ID: 29080 | HGNC ID: HGNC:25005 | Ensembl Gene: ENSG00000133773 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CCDC59:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCDC59 | 29080 | 222792_s_at | 0.2415 | 0.7379 | |
| GSE20347 | CCDC59 | 29080 | 218936_s_at | 0.4645 | 0.0017 | |
| GSE23400 | CCDC59 | 29080 | 218936_s_at | 0.5024 | 0.0000 | |
| GSE26886 | CCDC59 | 29080 | 222792_s_at | 1.0176 | 0.0000 | |
| GSE29001 | CCDC59 | 29080 | 218936_s_at | 0.4696 | 0.1222 | |
| GSE38129 | CCDC59 | 29080 | 218936_s_at | 0.3889 | 0.0004 | |
| GSE45670 | CCDC59 | 29080 | 222792_s_at | 0.2071 | 0.0626 | |
| GSE53622 | CCDC59 | 29080 | 97451 | 0.3227 | 0.0000 | |
| GSE53624 | CCDC59 | 29080 | 97451 | 0.4230 | 0.0000 | |
| GSE63941 | CCDC59 | 29080 | 222792_s_at | -0.1054 | 0.8787 | |
| GSE77861 | CCDC59 | 29080 | 222792_s_at | 0.5377 | 0.0155 | |
| GSE97050 | CCDC59 | 29080 | A_23_P105664 | 0.0729 | 0.8554 | |
| SRP007169 | CCDC59 | 29080 | RNAseq | 0.0496 | 0.9112 | |
| SRP008496 | CCDC59 | 29080 | RNAseq | 0.1958 | 0.5302 | |
| SRP064894 | CCDC59 | 29080 | RNAseq | 0.0563 | 0.7384 | |
| SRP133303 | CCDC59 | 29080 | RNAseq | 0.4327 | 0.0281 | |
| SRP159526 | CCDC59 | 29080 | RNAseq | 0.5134 | 0.0090 | |
| SRP193095 | CCDC59 | 29080 | RNAseq | 0.1577 | 0.1468 | |
| SRP219564 | CCDC59 | 29080 | RNAseq | 0.3401 | 0.1590 | |
| TCGA | CCDC59 | 29080 | RNAseq | 0.1531 | 0.0106 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CCDC59 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCDC59:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCDC59 | 29080 | 2 | 4 | 24 | |
| GSE20123 | CCDC59 | 29080 | 2 | 4 | 24 | |
| GSE43470 | CCDC59 | 29080 | 3 | 1 | 39 | |
| GSE46452 | CCDC59 | 29080 | 9 | 1 | 49 | |
| GSE47630 | CCDC59 | 29080 | 10 | 1 | 29 | |
| GSE54993 | CCDC59 | 29080 | 0 | 5 | 65 | |
| GSE54994 | CCDC59 | 29080 | 7 | 1 | 45 | |
| GSE60625 | CCDC59 | 29080 | 0 | 0 | 11 | |
| GSE74703 | CCDC59 | 29080 | 3 | 1 | 32 | |
| GSE74704 | CCDC59 | 29080 | 1 | 3 | 16 | |
| TCGA | CCDC59 | 29080 | 19 | 10 | 67 |
Total number of gains: 56; Total number of losses: 31; Total Number of normals: 401.
Somatic mutations of CCDC59:
Generating mutation plots.
Highly correlated genes for CCDC59:
Showing top 20/1144 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCDC59 | ZNF584 | 0.801731 | 3 | 0 | 3 |
| CCDC59 | ZNF579 | 0.799144 | 3 | 0 | 3 |
| CCDC59 | XAB2 | 0.794597 | 3 | 0 | 3 |
| CCDC59 | ZBED6 | 0.785655 | 3 | 0 | 3 |
| CCDC59 | PPP1R16A | 0.785587 | 3 | 0 | 3 |
| CCDC59 | LTBR | 0.775538 | 3 | 0 | 3 |
| CCDC59 | ITM2C | 0.77009 | 3 | 0 | 3 |
| CCDC59 | TUBGCP3 | 0.769502 | 3 | 0 | 3 |
| CCDC59 | ALG1 | 0.759787 | 3 | 0 | 3 |
| CCDC59 | NPHP3 | 0.752432 | 3 | 0 | 3 |
| CCDC59 | KLHL24 | 0.74833 | 3 | 0 | 3 |
| CCDC59 | ALKBH6 | 0.74388 | 4 | 0 | 3 |
| CCDC59 | FIP1L1 | 0.742237 | 4 | 0 | 4 |
| CCDC59 | RAB28 | 0.737816 | 3 | 0 | 3 |
| CCDC59 | DCUN1D2 | 0.719407 | 3 | 0 | 3 |
| CCDC59 | ZNF766 | 0.718174 | 3 | 0 | 3 |
| CCDC59 | TSNARE1 | 0.718078 | 3 | 0 | 3 |
| CCDC59 | AURKAIP1 | 0.717112 | 4 | 0 | 4 |
| CCDC59 | LGALS8 | 0.714472 | 3 | 0 | 3 |
| CCDC59 | ARHGAP24 | 0.711002 | 3 | 0 | 3 |
For details and further investigation, click here
