| Full name: pyruvate dehydrogenase kinase 2 | Alias Symbol: PDHK2 | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 5164 | HGNC ID: HGNC:8810 | Ensembl Gene: ENSG00000005882 | OMIM ID: 602525 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PDK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDK2 | 5164 | 202590_s_at | -0.2899 | 0.4268 | |
| GSE20347 | PDK2 | 5164 | 213724_s_at | -0.0133 | 0.8686 | |
| GSE23400 | PDK2 | 5164 | 213724_s_at | -0.1043 | 0.0136 | |
| GSE26886 | PDK2 | 5164 | 202590_s_at | -0.2086 | 0.3276 | |
| GSE29001 | PDK2 | 5164 | 202590_s_at | -0.3146 | 0.0850 | |
| GSE38129 | PDK2 | 5164 | 202590_s_at | -0.4308 | 0.0009 | |
| GSE45670 | PDK2 | 5164 | 202590_s_at | -0.2951 | 0.0237 | |
| GSE63941 | PDK2 | 5164 | 213724_s_at | 0.8179 | 0.0078 | |
| GSE77861 | PDK2 | 5164 | 202590_s_at | -0.1252 | 0.6060 | |
| GSE97050 | PDK2 | 5164 | A_23_P207517 | -0.4904 | 0.3073 | |
| SRP007169 | PDK2 | 5164 | RNAseq | -0.6862 | 0.0865 | |
| SRP008496 | PDK2 | 5164 | RNAseq | -0.6004 | 0.0217 | |
| SRP064894 | PDK2 | 5164 | RNAseq | 0.0221 | 0.9300 | |
| SRP133303 | PDK2 | 5164 | RNAseq | -0.2820 | 0.1847 | |
| SRP159526 | PDK2 | 5164 | RNAseq | -0.2337 | 0.2861 | |
| SRP193095 | PDK2 | 5164 | RNAseq | -0.1703 | 0.2381 | |
| SRP219564 | PDK2 | 5164 | RNAseq | -0.3708 | 0.4011 | |
| TCGA | PDK2 | 5164 | RNAseq | -0.3127 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PDK2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PDK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDK2 | 5164 | 5 | 2 | 23 | |
| GSE20123 | PDK2 | 5164 | 5 | 2 | 23 | |
| GSE43470 | PDK2 | 5164 | 3 | 2 | 38 | |
| GSE46452 | PDK2 | 5164 | 32 | 0 | 27 | |
| GSE47630 | PDK2 | 5164 | 9 | 0 | 31 | |
| GSE54993 | PDK2 | 5164 | 2 | 4 | 64 | |
| GSE54994 | PDK2 | 5164 | 9 | 6 | 38 | |
| GSE60625 | PDK2 | 5164 | 4 | 0 | 7 | |
| GSE74703 | PDK2 | 5164 | 3 | 2 | 31 | |
| GSE74704 | PDK2 | 5164 | 4 | 1 | 15 | |
| TCGA | PDK2 | 5164 | 27 | 7 | 62 |
Total number of gains: 103; Total number of losses: 26; Total Number of normals: 359.
Somatic mutations of PDK2:
Generating mutation plots.
Highly correlated genes for PDK2:
Showing top 20/631 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDK2 | RNASE4 | 0.83885 | 3 | 0 | 3 |
| PDK2 | MAOB | 0.823745 | 3 | 0 | 3 |
| PDK2 | PITPNM2 | 0.792992 | 3 | 0 | 3 |
| PDK2 | RNF14 | 0.785168 | 3 | 0 | 3 |
| PDK2 | IFT88 | 0.78205 | 3 | 0 | 3 |
| PDK2 | TSC22D1 | 0.771008 | 3 | 0 | 3 |
| PDK2 | EID1 | 0.77096 | 3 | 0 | 3 |
| PDK2 | DVL1 | 0.770169 | 3 | 0 | 3 |
| PDK2 | TSPAN2 | 0.768688 | 3 | 0 | 3 |
| PDK2 | MMRN2 | 0.763626 | 3 | 0 | 3 |
| PDK2 | APBA1 | 0.763252 | 3 | 0 | 3 |
| PDK2 | EIF4ENIF1 | 0.760235 | 3 | 0 | 3 |
| PDK2 | COG1 | 0.758802 | 3 | 0 | 3 |
| PDK2 | LIFR | 0.755249 | 3 | 0 | 3 |
| PDK2 | PLCB4 | 0.754914 | 3 | 0 | 3 |
| PDK2 | HSPB6 | 0.754562 | 4 | 0 | 4 |
| PDK2 | ZNF423 | 0.748486 | 4 | 0 | 4 |
| PDK2 | DIAPH2 | 0.746223 | 3 | 0 | 3 |
| PDK2 | CTF1 | 0.742751 | 4 | 0 | 3 |
| PDK2 | DCP1A | 0.740594 | 3 | 0 | 3 |
For details and further investigation, click here
