| Full name: heat shock protein family B (small) member 2 | Alias Symbol: Hs.78846|MKBP | ||
| Type: protein-coding gene | Cytoband: 11q23.1 | ||
| Entrez ID: 3316 | HGNC ID: HGNC:5247 | Ensembl Gene: ENSG00000170276 | OMIM ID: 602179 |
| Drug and gene relationship at DGIdb | |||
HSPB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of HSPB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSPB2 | 3316 | 205824_at | -0.8286 | 0.1720 | |
| GSE20347 | HSPB2 | 3316 | 205824_at | -0.3076 | 0.0068 | |
| GSE23400 | HSPB2 | 3316 | 205824_at | -0.3910 | 0.0000 | |
| GSE26886 | HSPB2 | 3316 | 205824_at | 0.1372 | 0.4263 | |
| GSE29001 | HSPB2 | 3316 | 205824_at | -0.2619 | 0.2433 | |
| GSE38129 | HSPB2 | 3316 | 205824_at | -0.9264 | 0.0001 | |
| GSE45670 | HSPB2 | 3316 | 205824_at | -1.0419 | 0.0000 | |
| GSE53622 | HSPB2 | 3316 | 146353 | -1.1078 | 0.0000 | |
| GSE53624 | HSPB2 | 3316 | 146353 | -0.9490 | 0.0000 | |
| GSE63941 | HSPB2 | 3316 | 205824_at | -1.7076 | 0.0000 | |
| GSE77861 | HSPB2 | 3316 | 205824_at | -0.1563 | 0.2261 | |
| GSE97050 | HSPB2 | 3316 | A_23_P161727 | -0.6248 | 0.2515 | |
| SRP007169 | HSPB2 | 3316 | RNAseq | 1.7380 | 0.0169 | |
| SRP064894 | HSPB2 | 3316 | RNAseq | 0.1954 | 0.7047 | |
| SRP133303 | HSPB2 | 3316 | RNAseq | -0.8926 | 0.0755 | |
| SRP159526 | HSPB2 | 3316 | RNAseq | -0.7405 | 0.1595 | |
| SRP219564 | HSPB2 | 3316 | RNAseq | -0.7865 | 0.3852 | |
| TCGA | HSPB2 | 3316 | RNAseq | -0.8478 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by HSPB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSPB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSPB2 | 3316 | 0 | 12 | 18 | |
| GSE20123 | HSPB2 | 3316 | 0 | 12 | 18 | |
| GSE43470 | HSPB2 | 3316 | 2 | 6 | 35 | |
| GSE46452 | HSPB2 | 3316 | 3 | 26 | 30 | |
| GSE47630 | HSPB2 | 3316 | 2 | 19 | 19 | |
| GSE54993 | HSPB2 | 3316 | 10 | 0 | 60 | |
| GSE54994 | HSPB2 | 3316 | 5 | 19 | 29 | |
| GSE60625 | HSPB2 | 3316 | 0 | 3 | 8 | |
| GSE74703 | HSPB2 | 3316 | 1 | 4 | 31 | |
| GSE74704 | HSPB2 | 3316 | 0 | 8 | 12 | |
| TCGA | HSPB2 | 3316 | 6 | 48 | 42 |
Total number of gains: 29; Total number of losses: 157; Total Number of normals: 302.
Somatic mutations of HSPB2:
Generating mutation plots.
Highly correlated genes for HSPB2:
Showing top 20/1017 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSPB2 | NEGR1 | 0.799702 | 6 | 0 | 6 |
| HSPB2 | PNMA2 | 0.790741 | 3 | 0 | 3 |
| HSPB2 | PABPC5 | 0.77951 | 5 | 0 | 5 |
| HSPB2 | ZNF582 | 0.77512 | 4 | 0 | 4 |
| HSPB2 | MIR100HG | 0.774866 | 5 | 0 | 5 |
| HSPB2 | FXYD1 | 0.771651 | 8 | 0 | 8 |
| HSPB2 | SMIM10 | 0.770439 | 6 | 0 | 6 |
| HSPB2 | NFASC | 0.76542 | 6 | 0 | 6 |
| HSPB2 | PID1 | 0.75684 | 10 | 0 | 10 |
| HSPB2 | FGF7 | 0.751233 | 7 | 0 | 7 |
| HSPB2 | ADAMTSL1 | 0.747287 | 6 | 0 | 6 |
| HSPB2 | LINC01279 | 0.7468 | 4 | 0 | 4 |
| HSPB2 | TMEM100 | 0.745279 | 9 | 0 | 9 |
| HSPB2 | RAI2 | 0.742126 | 9 | 0 | 9 |
| HSPB2 | CCDC69 | 0.741986 | 9 | 0 | 9 |
| HSPB2 | MAGI2-AS3 | 0.741116 | 6 | 0 | 5 |
| HSPB2 | BHMT2 | 0.738315 | 10 | 0 | 10 |
| HSPB2 | CNRIP1 | 0.737917 | 7 | 0 | 7 |
| HSPB2 | PDE2A | 0.737536 | 9 | 0 | 9 |
| HSPB2 | DIXDC1 | 0.735769 | 9 | 0 | 8 |
For details and further investigation, click here
