| Full name: homeobox B6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 3216 | HGNC ID: HGNC:5117 | Ensembl Gene: ENSG00000108511 | OMIM ID: 142961 |
| Drug and gene relationship at DGIdb | |||
Expression of HOXB6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HOXB6 | 3216 | 205366_s_at | 0.3824 | 0.2033 | |
| GSE20347 | HOXB6 | 3216 | 205366_s_at | 0.3983 | 0.0057 | |
| GSE23400 | HOXB6 | 3216 | 205366_s_at | 0.0658 | 0.1614 | |
| GSE26886 | HOXB6 | 3216 | 205365_at | 0.1528 | 0.1239 | |
| GSE29001 | HOXB6 | 3216 | 205365_at | -0.2539 | 0.1125 | |
| GSE38129 | HOXB6 | 3216 | 205366_s_at | 0.2787 | 0.0698 | |
| GSE45670 | HOXB6 | 3216 | 205366_s_at | 0.3581 | 0.0639 | |
| GSE53622 | HOXB6 | 3216 | 125477 | 1.0827 | 0.0000 | |
| GSE53624 | HOXB6 | 3216 | 125477 | 1.3803 | 0.0000 | |
| GSE63941 | HOXB6 | 3216 | 205366_s_at | 0.3879 | 0.6982 | |
| GSE77861 | HOXB6 | 3216 | 205366_s_at | -0.0451 | 0.7302 | |
| GSE97050 | HOXB6 | 3216 | A_23_P66682 | 0.3902 | 0.1662 | |
| SRP064894 | HOXB6 | 3216 | RNAseq | 1.7608 | 0.0000 | |
| SRP133303 | HOXB6 | 3216 | RNAseq | 1.1026 | 0.0001 | |
| SRP159526 | HOXB6 | 3216 | RNAseq | 2.9200 | 0.0000 | |
| SRP219564 | HOXB6 | 3216 | RNAseq | 0.9532 | 0.2069 | |
| TCGA | HOXB6 | 3216 | RNAseq | 0.2968 | 0.2702 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by HOXB6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HOXB6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HOXB6 | 3216 | 5 | 2 | 23 | |
| GSE20123 | HOXB6 | 3216 | 5 | 2 | 23 | |
| GSE43470 | HOXB6 | 3216 | 3 | 1 | 39 | |
| GSE46452 | HOXB6 | 3216 | 32 | 0 | 27 | |
| GSE47630 | HOXB6 | 3216 | 9 | 0 | 31 | |
| GSE54993 | HOXB6 | 3216 | 2 | 4 | 64 | |
| GSE54994 | HOXB6 | 3216 | 10 | 6 | 37 | |
| GSE60625 | HOXB6 | 3216 | 4 | 0 | 7 | |
| GSE74703 | HOXB6 | 3216 | 3 | 1 | 32 | |
| GSE74704 | HOXB6 | 3216 | 4 | 1 | 15 | |
| TCGA | HOXB6 | 3216 | 27 | 6 | 63 |
Total number of gains: 104; Total number of losses: 23; Total Number of normals: 361.
Somatic mutations of HOXB6:
Generating mutation plots.
Highly correlated genes for HOXB6:
Showing top 20/145 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HOXB6 | PPP1R14D | 0.778987 | 3 | 0 | 3 |
| HOXB6 | HTR6 | 0.751581 | 3 | 0 | 3 |
| HOXB6 | GHSR | 0.744085 | 3 | 0 | 3 |
| HOXB6 | TRIM17 | 0.729885 | 3 | 0 | 3 |
| HOXB6 | SIGLEC7 | 0.728977 | 3 | 0 | 3 |
| HOXB6 | TRIM10 | 0.723166 | 3 | 0 | 3 |
| HOXB6 | ADAM21 | 0.718373 | 3 | 0 | 3 |
| HOXB6 | GPR32 | 0.715895 | 3 | 0 | 3 |
| HOXB6 | KIF17 | 0.700911 | 3 | 0 | 3 |
| HOXB6 | LILRA1 | 0.698093 | 3 | 0 | 3 |
| HOXB6 | MAPK8IP2 | 0.695772 | 3 | 0 | 3 |
| HOXB6 | ZNRF4 | 0.695231 | 3 | 0 | 3 |
| HOXB6 | P2RY4 | 0.692864 | 3 | 0 | 3 |
| HOXB6 | FABP7 | 0.690897 | 3 | 0 | 3 |
| HOXB6 | TRPM3 | 0.690407 | 3 | 0 | 3 |
| HOXB6 | FCRL2 | 0.680964 | 3 | 0 | 3 |
| HOXB6 | CLDN9 | 0.674977 | 3 | 0 | 3 |
| HOXB6 | HOXC9 | 0.672298 | 3 | 0 | 3 |
| HOXB6 | KLK14 | 0.65815 | 3 | 0 | 3 |
| HOXB6 | TMEM263 | 0.656088 | 3 | 0 | 3 |
For details and further investigation, click here
