IFNB1

 

Full name: interferon beta 1 Alias Symbol: IFB|IFF
Type: protein-coding gene Cytoband: 9p21.3
Entrez ID: 3456 HGNC ID: HGNC:5434 Ensembl Gene: ENSG00000171855 OMIM ID: 147640
Drug and gene relationship at DGIdb

 

IFNB1 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A

 

Expression of IFNB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IFNB1 3456 208173_at 0.0374 0.9135
GSE20347 IFNB1 3456 208173_at 0.0227 0.7865
GSE23400 IFNB1 3456 208173_at -0.0259 0.4690
GSE26886 IFNB1 3456 208173_at 0.1216 0.3943
GSE29001 IFNB1 3456 208173_at -0.0333 0.8467
GSE38129 IFNB1 3456 208173_at -0.0544 0.4783
GSE45670 IFNB1 3456 208173_at -0.0362 0.6566
GSE53622 IFNB1 3456 34761 -0.0816 0.5289
GSE53624 IFNB1 3456 34761 0.1822 0.1088
GSE63941 IFNB1 3456 208173_at 0.1680 0.3369
GSE77861 IFNB1 3456 208173_at 0.0827 0.3470
TCGA IFNB1 3456 RNAseq 2.1476 0.1340

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IFNB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IFNB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IFNB1 3456 2 16 12
GSE20123 IFNB1 3456 2 16 12
GSE43470 IFNB1 3456 4 13 26
GSE46452 IFNB1 3456 2 23 34
GSE47630 IFNB1 3456 3 27 10
GSE54993 IFNB1 3456 7 2 61
GSE54994 IFNB1 3456 8 16 29
GSE60625 IFNB1 3456 3 0 8
GSE74703 IFNB1 3456 4 10 22
GSE74704 IFNB1 3456 0 13 7
TCGA IFNB1 3456 11 53 32

Total number of gains: 46; Total number of losses: 189; Total Number of normals: 253.  

 

Somatic mutations of IFNB1:

 

Generating mutation plots.

 

Highly correlated genes for IFNB1:

 

Showing top 20/199 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IFNB1CRYBA10.679922404
IFNB1CHML0.644425303
IFNB1CALCB0.643595303
IFNB1KIR2DL5A0.642036303
IFNB1MYH80.641481303
IFNB1RENBP0.634968303
IFNB1OR3A10.622395303
IFNB1SLC5A20.621863404
IFNB1MS4A120.621247403
IFNB1CD800.615651303
IFNB1GRM30.613181403
IFNB1MC2R0.605277403
IFNB1TNFRSF10C0.602407403
IFNB1KCNQ30.59987403
IFNB1GRIA30.599095303
IFNB1RAB33A0.597895303
IFNB1PPP1R170.59688403
IFNB1BTG40.596759403
IFNB1OR4D10.596644303
IFNB1CYP2D60.594595303

For details and further investigation, click here