| Full name: CD80 molecule | Alias Symbol: B7.1|B7-1 | ||
| Type: protein-coding gene | Cytoband: 3q13.33 | ||
| Entrez ID: 941 | HGNC ID: HGNC:1700 | Ensembl Gene: ENSG00000121594 | OMIM ID: 112203 |
| Drug and gene relationship at DGIdb | |||
CD80 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04620 | Toll-like receptor signaling pathway |
Expression of CD80:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD80 | 941 | 207176_s_at | 0.5091 | 0.0734 | |
| GSE20347 | CD80 | 941 | 207176_s_at | 0.1491 | 0.0765 | |
| GSE23400 | CD80 | 941 | 207176_s_at | -0.0492 | 0.2403 | |
| GSE26886 | CD80 | 941 | 207176_s_at | -0.0385 | 0.8263 | |
| GSE29001 | CD80 | 941 | 207176_s_at | -0.0241 | 0.9234 | |
| GSE38129 | CD80 | 941 | 207176_s_at | 0.0738 | 0.4269 | |
| GSE45670 | CD80 | 941 | 1554519_at | 0.4664 | 0.0013 | |
| GSE63941 | CD80 | 941 | 207176_s_at | 0.0902 | 0.6002 | |
| GSE77861 | CD80 | 941 | 207176_s_at | -0.0187 | 0.8820 | |
| GSE97050 | CD80 | 941 | A_24_P320033 | 1.1695 | 0.0555 | |
| SRP007169 | CD80 | 941 | RNAseq | 4.8831 | 0.0004 | |
| SRP133303 | CD80 | 941 | RNAseq | 2.1474 | 0.0000 | |
| SRP159526 | CD80 | 941 | RNAseq | 1.0786 | 0.1847 | |
| SRP193095 | CD80 | 941 | RNAseq | 1.6979 | 0.0000 | |
| TCGA | CD80 | 941 | RNAseq | 1.9758 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by CD80 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CD80:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD80 | 941 | 17 | 0 | 13 | |
| GSE20123 | CD80 | 941 | 17 | 0 | 13 | |
| GSE43470 | CD80 | 941 | 21 | 1 | 21 | |
| GSE46452 | CD80 | 941 | 14 | 5 | 40 | |
| GSE47630 | CD80 | 941 | 16 | 5 | 19 | |
| GSE54993 | CD80 | 941 | 2 | 6 | 62 | |
| GSE54994 | CD80 | 941 | 30 | 4 | 19 | |
| GSE60625 | CD80 | 941 | 0 | 6 | 5 | |
| GSE74703 | CD80 | 941 | 17 | 1 | 18 | |
| GSE74704 | CD80 | 941 | 13 | 0 | 7 | |
| TCGA | CD80 | 941 | 53 | 7 | 36 |
Total number of gains: 200; Total number of losses: 35; Total Number of normals: 253.
Somatic mutations of CD80:
Generating mutation plots.
Highly correlated genes for CD80:
Showing top 20/701 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD80 | HERC5 | 0.808689 | 3 | 0 | 3 |
| CD80 | ADAR | 0.802346 | 3 | 0 | 3 |
| CD80 | PARP14 | 0.793631 | 3 | 0 | 3 |
| CD80 | MARCKSL1 | 0.787489 | 3 | 0 | 3 |
| CD80 | HLA-A | 0.785107 | 3 | 0 | 3 |
| CD80 | DDX60 | 0.777571 | 3 | 0 | 3 |
| CD80 | ZNFX1 | 0.776096 | 3 | 0 | 3 |
| CD80 | TAP1 | 0.775332 | 3 | 0 | 3 |
| CD80 | TAPBP | 0.765994 | 3 | 0 | 3 |
| CD80 | LPCAT1 | 0.759686 | 3 | 0 | 3 |
| CD80 | DDX60L | 0.758376 | 3 | 0 | 3 |
| CD80 | MCM3 | 0.745923 | 3 | 0 | 3 |
| CD80 | GTDC1 | 0.742729 | 3 | 0 | 3 |
| CD80 | LY6E | 0.742347 | 3 | 0 | 3 |
| CD80 | GBP1 | 0.740867 | 3 | 0 | 3 |
| CD80 | CCM2 | 0.740418 | 3 | 0 | 3 |
| CD80 | IFIH1 | 0.735081 | 3 | 0 | 3 |
| CD80 | ZYX | 0.732946 | 3 | 0 | 3 |
| CD80 | ETS1 | 0.731791 | 3 | 0 | 3 |
| CD80 | PARP12 | 0.72563 | 3 | 0 | 3 |
For details and further investigation, click here
