| Full name: TNF receptor superfamily member 10c | Alias Symbol: DcR1|TRAILR3|LIT|TRID|CD263 | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 8794 | HGNC ID: HGNC:11906 | Ensembl Gene: ENSG00000173535 | OMIM ID: 603613 |
| Drug and gene relationship at DGIdb | |||
TNFRSF10C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis | |
| hsa04650 | Natural killer cell mediated cytotoxicity | |
| hsa05162 | Measles |
Expression of TNFRSF10C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFRSF10C | 8794 | 234644_x_at | 0.1000 | 0.6892 | |
| GSE20347 | TNFRSF10C | 8794 | 206222_at | 0.1343 | 0.1356 | |
| GSE23400 | TNFRSF10C | 8794 | 211163_s_at | -0.0514 | 0.0222 | |
| GSE26886 | TNFRSF10C | 8794 | 234644_x_at | 0.1933 | 0.0548 | |
| GSE29001 | TNFRSF10C | 8794 | 211163_s_at | -0.0688 | 0.6571 | |
| GSE38129 | TNFRSF10C | 8794 | 206222_at | 0.0907 | 0.3056 | |
| GSE45670 | TNFRSF10C | 8794 | 234644_x_at | 0.1296 | 0.2459 | |
| GSE53622 | TNFRSF10C | 8794 | 10861 | 0.2815 | 0.0008 | |
| GSE53624 | TNFRSF10C | 8794 | 10861 | 0.4903 | 0.0000 | |
| GSE63941 | TNFRSF10C | 8794 | 234644_x_at | 0.1218 | 0.6397 | |
| GSE77861 | TNFRSF10C | 8794 | 234644_x_at | -0.1172 | 0.3360 | |
| GSE97050 | TNFRSF10C | 8794 | A_23_P256724 | -0.1067 | 0.8863 | |
| SRP133303 | TNFRSF10C | 8794 | RNAseq | 0.4185 | 0.2822 | |
| SRP159526 | TNFRSF10C | 8794 | RNAseq | 1.4409 | 0.0316 | |
| SRP193095 | TNFRSF10C | 8794 | RNAseq | 2.0841 | 0.0000 | |
| SRP219564 | TNFRSF10C | 8794 | RNAseq | 0.3971 | 0.3833 | |
| TCGA | TNFRSF10C | 8794 | RNAseq | -1.1925 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by TNFRSF10C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFRSF10C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFRSF10C | 8794 | 4 | 11 | 15 | |
| GSE20123 | TNFRSF10C | 8794 | 4 | 11 | 15 | |
| GSE43470 | TNFRSF10C | 8794 | 4 | 9 | 30 | |
| GSE46452 | TNFRSF10C | 8794 | 13 | 13 | 33 | |
| GSE47630 | TNFRSF10C | 8794 | 10 | 8 | 22 | |
| GSE54993 | TNFRSF10C | 8794 | 2 | 14 | 54 | |
| GSE54994 | TNFRSF10C | 8794 | 8 | 18 | 27 | |
| GSE60625 | TNFRSF10C | 8794 | 3 | 0 | 8 | |
| GSE74703 | TNFRSF10C | 8794 | 4 | 7 | 25 | |
| GSE74704 | TNFRSF10C | 8794 | 3 | 8 | 9 | |
| TCGA | TNFRSF10C | 8794 | 14 | 43 | 39 |
Total number of gains: 69; Total number of losses: 142; Total Number of normals: 277.
Somatic mutations of TNFRSF10C:
Generating mutation plots.
Highly correlated genes for TNFRSF10C:
Showing top 20/509 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFRSF10C | PROK2 | 0.830549 | 3 | 0 | 3 |
| TNFRSF10C | AQP9 | 0.725768 | 4 | 0 | 4 |
| TNFRSF10C | ASB3 | 0.718676 | 3 | 0 | 3 |
| TNFRSF10C | NPB | 0.714502 | 3 | 0 | 3 |
| TNFRSF10C | NANOS3 | 0.712745 | 4 | 0 | 4 |
| TNFRSF10C | MYO1F | 0.711578 | 3 | 0 | 3 |
| TNFRSF10C | GLT1D1 | 0.70052 | 3 | 0 | 3 |
| TNFRSF10C | ALG11 | 0.695675 | 3 | 0 | 3 |
| TNFRSF10C | GRIN3B | 0.68781 | 3 | 0 | 3 |
| TNFRSF10C | CTXN1 | 0.686772 | 3 | 0 | 3 |
| TNFRSF10C | SPEG | 0.686633 | 3 | 0 | 3 |
| TNFRSF10C | ICAM5 | 0.684425 | 4 | 0 | 3 |
| TNFRSF10C | CSDC2 | 0.683918 | 4 | 0 | 4 |
| TNFRSF10C | PRR23C | 0.680904 | 3 | 0 | 3 |
| TNFRSF10C | SPSB4 | 0.678165 | 3 | 0 | 3 |
| TNFRSF10C | KLHL31 | 0.677792 | 3 | 0 | 3 |
| TNFRSF10C | OR1L6 | 0.673013 | 3 | 0 | 3 |
| TNFRSF10C | ALMS1 | 0.671443 | 4 | 0 | 3 |
| TNFRSF10C | LINC00208 | 0.671295 | 3 | 0 | 3 |
| TNFRSF10C | ZNF20 | 0.669886 | 3 | 0 | 3 |
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