| Full name: glutamate metabotropic receptor 3 | Alias Symbol: GPRC1C|mGlu3|MGLUR3 | ||
| Type: protein-coding gene | Cytoband: 7q21.11-q21.12 | ||
| Entrez ID: 2913 | HGNC ID: HGNC:4595 | Ensembl Gene: ENSG00000198822 | OMIM ID: 601115 |
| Drug and gene relationship at DGIdb | |||
GRM3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04724 | Glutamatergic synapse | |
| hsa05030 | Cocaine addiction |
Expression of GRM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRM3 | 2913 | 205814_at | 0.0926 | 0.7511 | |
| GSE20347 | GRM3 | 2913 | 205814_at | 0.0204 | 0.8199 | |
| GSE23400 | GRM3 | 2913 | 205814_at | -0.0125 | 0.7454 | |
| GSE26886 | GRM3 | 2913 | 205814_at | 0.4510 | 0.0008 | |
| GSE29001 | GRM3 | 2913 | 205814_at | 0.1122 | 0.6211 | |
| GSE38129 | GRM3 | 2913 | 205814_at | 0.0033 | 0.9715 | |
| GSE45670 | GRM3 | 2913 | 205814_at | 0.0713 | 0.4364 | |
| GSE53622 | GRM3 | 2913 | 32955 | 0.6749 | 0.0000 | |
| GSE53624 | GRM3 | 2913 | 32955 | 0.7985 | 0.0000 | |
| GSE63941 | GRM3 | 2913 | 205814_at | 0.1016 | 0.6165 | |
| GSE77861 | GRM3 | 2913 | 205814_at | 0.0061 | 0.9568 | |
| TCGA | GRM3 | 2913 | RNAseq | 0.8432 | 0.1337 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GRM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRM3 | 2913 | 13 | 1 | 16 | |
| GSE20123 | GRM3 | 2913 | 12 | 1 | 17 | |
| GSE43470 | GRM3 | 2913 | 5 | 1 | 37 | |
| GSE46452 | GRM3 | 2913 | 12 | 0 | 47 | |
| GSE47630 | GRM3 | 2913 | 8 | 2 | 30 | |
| GSE54993 | GRM3 | 2913 | 2 | 7 | 61 | |
| GSE54994 | GRM3 | 2913 | 16 | 3 | 34 | |
| GSE60625 | GRM3 | 2913 | 0 | 0 | 11 | |
| GSE74703 | GRM3 | 2913 | 4 | 1 | 31 | |
| GSE74704 | GRM3 | 2913 | 9 | 1 | 10 | |
| TCGA | GRM3 | 2913 | 54 | 4 | 38 |
Total number of gains: 135; Total number of losses: 21; Total Number of normals: 332.
Somatic mutations of GRM3:
Generating mutation plots.
Highly correlated genes for GRM3:
Showing top 20/457 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRM3 | KCND2 | 0.736152 | 3 | 0 | 3 |
| GRM3 | RIMS4 | 0.672868 | 3 | 0 | 3 |
| GRM3 | SYDE1 | 0.6681 | 3 | 0 | 3 |
| GRM3 | EPX | 0.666688 | 5 | 0 | 5 |
| GRM3 | DNM1 | 0.662404 | 3 | 0 | 3 |
| GRM3 | ADAM21 | 0.66038 | 5 | 0 | 5 |
| GRM3 | GML | 0.659032 | 4 | 0 | 4 |
| GRM3 | NME8 | 0.656087 | 4 | 0 | 4 |
| GRM3 | TUT1 | 0.655301 | 3 | 0 | 3 |
| GRM3 | OR51E2 | 0.648885 | 6 | 0 | 4 |
| GRM3 | RET | 0.646965 | 3 | 0 | 3 |
| GRM3 | TCTE1 | 0.645204 | 4 | 0 | 3 |
| GRM3 | CRYBA1 | 0.645089 | 5 | 0 | 5 |
| GRM3 | B3GALT1 | 0.643668 | 4 | 0 | 4 |
| GRM3 | SLC30A3 | 0.64342 | 4 | 0 | 4 |
| GRM3 | GGT5 | 0.641499 | 3 | 0 | 3 |
| GRM3 | ZNF484 | 0.639 | 4 | 0 | 4 |
| GRM3 | MAPK15 | 0.635307 | 4 | 0 | 3 |
| GRM3 | LINC00475 | 0.634327 | 3 | 0 | 3 |
| GRM3 | LINC00659 | 0.63347 | 3 | 0 | 3 |
For details and further investigation, click here
