| Full name: potassium voltage-gated channel subfamily Q member 3 | Alias Symbol: Kv7.3 | ||
| Type: protein-coding gene | Cytoband: 8q24.22 | ||
| Entrez ID: 3786 | HGNC ID: HGNC:6297 | Ensembl Gene: ENSG00000184156 | OMIM ID: 602232 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNQ3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNQ3 | 3786 | 228579_at | 0.0155 | 0.9619 | |
| GSE20347 | KCNQ3 | 3786 | 206573_at | -0.1092 | 0.1673 | |
| GSE23400 | KCNQ3 | 3786 | 206573_at | -0.0759 | 0.1034 | |
| GSE26886 | KCNQ3 | 3786 | 228579_at | 0.0046 | 0.9878 | |
| GSE29001 | KCNQ3 | 3786 | 206573_at | -0.0313 | 0.7990 | |
| GSE38129 | KCNQ3 | 3786 | 206573_at | -0.0983 | 0.2634 | |
| GSE45670 | KCNQ3 | 3786 | 228579_at | -0.0635 | 0.6269 | |
| GSE53622 | KCNQ3 | 3786 | 8014 | 0.4903 | 0.0055 | |
| GSE53624 | KCNQ3 | 3786 | 8014 | 0.7380 | 0.0000 | |
| GSE63941 | KCNQ3 | 3786 | 228579_at | -0.3716 | 0.0316 | |
| GSE77861 | KCNQ3 | 3786 | 228579_at | -0.0774 | 0.2740 | |
| GSE97050 | KCNQ3 | 3786 | A_23_P123393 | 0.0098 | 0.9766 | |
| SRP133303 | KCNQ3 | 3786 | RNAseq | 0.7246 | 0.0116 | |
| SRP159526 | KCNQ3 | 3786 | RNAseq | 1.3959 | 0.0179 | |
| SRP219564 | KCNQ3 | 3786 | RNAseq | 0.2703 | 0.5776 | |
| TCGA | KCNQ3 | 3786 | RNAseq | -0.1372 | 0.8006 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by KCNQ3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNQ3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNQ3 | 3786 | 18 | 0 | 12 | |
| GSE20123 | KCNQ3 | 3786 | 18 | 0 | 12 | |
| GSE43470 | KCNQ3 | 3786 | 23 | 1 | 19 | |
| GSE46452 | KCNQ3 | 3786 | 27 | 0 | 32 | |
| GSE47630 | KCNQ3 | 3786 | 24 | 0 | 16 | |
| GSE54993 | KCNQ3 | 3786 | 0 | 24 | 46 | |
| GSE54994 | KCNQ3 | 3786 | 39 | 1 | 13 | |
| GSE60625 | KCNQ3 | 3786 | 0 | 7 | 4 | |
| GSE74703 | KCNQ3 | 3786 | 20 | 0 | 16 | |
| GSE74704 | KCNQ3 | 3786 | 12 | 0 | 8 | |
| TCGA | KCNQ3 | 3786 | 67 | 2 | 27 |
Total number of gains: 248; Total number of losses: 35; Total Number of normals: 205.
Somatic mutations of KCNQ3:
Generating mutation plots.
Highly correlated genes for KCNQ3:
Showing top 20/555 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNQ3 | CNTF | 0.793831 | 3 | 0 | 3 |
| KCNQ3 | HFE | 0.778257 | 3 | 0 | 3 |
| KCNQ3 | SVEP1 | 0.740661 | 3 | 0 | 3 |
| KCNQ3 | RIT2 | 0.736308 | 3 | 0 | 3 |
| KCNQ3 | ATXN3L | 0.730041 | 3 | 0 | 3 |
| KCNQ3 | CLC | 0.7211 | 3 | 0 | 3 |
| KCNQ3 | GABRR2 | 0.700796 | 5 | 0 | 4 |
| KCNQ3 | KCNJ4 | 0.698893 | 3 | 0 | 3 |
| KCNQ3 | ATG10 | 0.694788 | 5 | 0 | 5 |
| KCNQ3 | CACNB1 | 0.694389 | 6 | 0 | 6 |
| KCNQ3 | HLA-DOA | 0.692813 | 5 | 0 | 5 |
| KCNQ3 | TMSB15B | 0.689129 | 3 | 0 | 3 |
| KCNQ3 | PHLDB1 | 0.686577 | 6 | 0 | 5 |
| KCNQ3 | KIR2DS5 | 0.686092 | 6 | 0 | 5 |
| KCNQ3 | ZNF334 | 0.685661 | 3 | 0 | 3 |
| KCNQ3 | AGT | 0.684382 | 3 | 0 | 3 |
| KCNQ3 | PKNOX2 | 0.683734 | 6 | 0 | 5 |
| KCNQ3 | MSRB3 | 0.681735 | 3 | 0 | 3 |
| KCNQ3 | LCE1E | 0.680595 | 3 | 0 | 3 |
| KCNQ3 | APBB1IP | 0.67555 | 4 | 0 | 3 |
For details and further investigation, click here
