| Full name: insulin like growth factor binding protein 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 3485 | HGNC ID: HGNC:5471 | Ensembl Gene: ENSG00000115457 | OMIM ID: 146731 |
| Drug and gene relationship at DGIdb | |||
Expression of IGFBP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGFBP2 | 3485 | 202718_at | -0.5333 | 0.6837 | |
| GSE20347 | IGFBP2 | 3485 | 202718_at | -0.4282 | 0.3947 | |
| GSE23400 | IGFBP2 | 3485 | 202718_at | 0.1483 | 0.5679 | |
| GSE26886 | IGFBP2 | 3485 | 202718_at | 0.5492 | 0.1630 | |
| GSE29001 | IGFBP2 | 3485 | 202718_at | -0.0219 | 0.9795 | |
| GSE38129 | IGFBP2 | 3485 | 202718_at | -0.1438 | 0.7286 | |
| GSE45670 | IGFBP2 | 3485 | 202718_at | 0.2337 | 0.6023 | |
| GSE53622 | IGFBP2 | 3485 | 75126 | 0.1879 | 0.1974 | |
| GSE53624 | IGFBP2 | 3485 | 75126 | 0.0013 | 0.9927 | |
| GSE63941 | IGFBP2 | 3485 | 202718_at | 2.6907 | 0.0851 | |
| GSE77861 | IGFBP2 | 3485 | 202718_at | 0.8424 | 0.1119 | |
| GSE97050 | IGFBP2 | 3485 | A_23_P119943 | -0.2327 | 0.7383 | |
| SRP007169 | IGFBP2 | 3485 | RNAseq | 0.8496 | 0.0605 | |
| SRP008496 | IGFBP2 | 3485 | RNAseq | 0.7392 | 0.0079 | |
| SRP064894 | IGFBP2 | 3485 | RNAseq | 1.0255 | 0.0292 | |
| SRP133303 | IGFBP2 | 3485 | RNAseq | 0.8487 | 0.0646 | |
| SRP159526 | IGFBP2 | 3485 | RNAseq | 1.3957 | 0.0367 | |
| SRP193095 | IGFBP2 | 3485 | RNAseq | 0.0528 | 0.8393 | |
| SRP219564 | IGFBP2 | 3485 | RNAseq | 0.4380 | 0.5675 | |
| TCGA | IGFBP2 | 3485 | RNAseq | -0.4405 | 0.0018 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by IGFBP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IGFBP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGFBP2 | 3485 | 1 | 13 | 16 | |
| GSE20123 | IGFBP2 | 3485 | 1 | 13 | 16 | |
| GSE43470 | IGFBP2 | 3485 | 0 | 7 | 36 | |
| GSE46452 | IGFBP2 | 3485 | 0 | 5 | 54 | |
| GSE47630 | IGFBP2 | 3485 | 4 | 5 | 31 | |
| GSE54993 | IGFBP2 | 3485 | 0 | 3 | 67 | |
| GSE54994 | IGFBP2 | 3485 | 8 | 9 | 36 | |
| GSE60625 | IGFBP2 | 3485 | 0 | 3 | 8 | |
| GSE74703 | IGFBP2 | 3485 | 0 | 6 | 30 | |
| GSE74704 | IGFBP2 | 3485 | 1 | 7 | 12 | |
| TCGA | IGFBP2 | 3485 | 11 | 27 | 58 |
Total number of gains: 26; Total number of losses: 98; Total Number of normals: 364.
Somatic mutations of IGFBP2:
Generating mutation plots.
Highly correlated genes for IGFBP2:
Showing all 16 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGFBP2 | UNC45A | 0.684455 | 3 | 0 | 3 |
| IGFBP2 | PPP1CA | 0.644787 | 3 | 0 | 3 |
| IGFBP2 | KIAA1549 | 0.636826 | 3 | 0 | 3 |
| IGFBP2 | VIPR1 | 0.605234 | 3 | 0 | 3 |
| IGFBP2 | ZNF503-AS2 | 0.596499 | 3 | 0 | 3 |
| IGFBP2 | TCF7L1 | 0.59628 | 4 | 0 | 3 |
| IGFBP2 | PDLIM1 | 0.584657 | 4 | 0 | 3 |
| IGFBP2 | INPP5J | 0.564383 | 6 | 0 | 4 |
| IGFBP2 | TPPP3 | 0.559486 | 4 | 0 | 3 |
| IGFBP2 | ZNF395 | 0.546138 | 4 | 0 | 3 |
| IGFBP2 | TNRC18 | 0.544615 | 3 | 0 | 3 |
| IGFBP2 | HMX1 | 0.539101 | 4 | 0 | 3 |
| IGFBP2 | LTBP4 | 0.537705 | 5 | 0 | 4 |
| IGFBP2 | NPR3 | 0.535112 | 4 | 0 | 3 |
| IGFBP2 | PKN3 | 0.523029 | 4 | 0 | 3 |
| IGFBP2 | BMP7 | 0.50619 | 9 | 0 | 4 |
For details and further investigation, click here
