Full name: protein phosphatase 1 catalytic subunit alpha	Alias Symbol: PP1A|PP-1A|PP1alpha
Type: protein-coding gene	Cytoband: 11q13
Entrez ID: 5499	HGNC ID: HGNC:9281	Ensembl Gene: ENSG00000172531	OMIM ID: 176875
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 154/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

---

 

PPP1CA involved pathways:

KEGG pathway	Description	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04024	cAMP signaling pathway	View
hsa04114	Oocyte meiosis	View
hsa04261	Adrenergic signaling in cardiomyocytes	View
hsa04270	Vascular smooth muscle contraction	View
hsa04390	Hippo signaling pathway	View
hsa04510	Focal adhesion	View
hsa04611	Platelet activation	View
hsa04720	Long-term potentiation	View
hsa04728	Dopaminergic synapse	View
hsa04750	Inflammatory mediator regulation of TRP channels	View
hsa04810	Regulation of actin cytoskeleton	View
hsa04910	Insulin signaling pathway	View
hsa04921	Oxytocin signaling pathway	View
hsa04931	Insulin resistance	View
hsa05031	Amphetamine addiction	View
hsa05034	Alcoholism	View
hsa05168	Herpes simplex infection	View
hsa05205	Proteoglycans in cancer	View

---

 

Expression of PPP1CA:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	PPP1CA	5499	200846_s_at	0.5565	0.3793	Show
GSE20347	PPP1CA	5499	200846_s_at	0.0734	0.7633	Show
GSE23400	PPP1CA	5499	200846_s_at	0.0926	0.3098	Show
GSE26886	PPP1CA	5499	200846_s_at	-0.6374	0.0356	Show
GSE29001	PPP1CA	5499	200846_s_at	-0.3885	0.2206	Show
GSE38129	PPP1CA	5499	200846_s_at	0.3925	0.0348	Show
GSE45670	PPP1CA	5499	200846_s_at	0.2376	0.3142	Show
GSE53622	PPP1CA	5499	93001	-0.0204	0.8570	Show
GSE53624	PPP1CA	5499	93001	0.1328	0.0427	Show
GSE63941	PPP1CA	5499	200846_s_at	3.2536	0.0000	Show
GSE77861	PPP1CA	5499	200846_s_at	0.2284	0.1981	Show
GSE97050	PPP1CA	5499	A_23_P323227	0.9822	0.1204	Show
SRP007169	PPP1CA	5499	RNAseq	-0.9799	0.0021	Show
SRP008496	PPP1CA	5499	RNAseq	-0.9573	0.0000	Show
SRP064894	PPP1CA	5499	RNAseq	-0.0759	0.7560	Show
SRP133303	PPP1CA	5499	RNAseq	0.3051	0.1360	Show
SRP159526	PPP1CA	5499	RNAseq	-0.1079	0.5770	Show
SRP193095	PPP1CA	5499	RNAseq	-0.2355	0.0936	Show
SRP219564	PPP1CA	5499	RNAseq	-0.0703	0.8848	Show
TCGA	PPP1CA	5499	RNAseq	0.2158	0.0001	Show

Upregulated datasets: 1; Downregulated datasets: 0.  Download Data

---

 

Survival by PPP1CA expression:

 

---

Copy number change of PPP1CA:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	PPP1CA	5499	9	4	17	Show
GSE20123	PPP1CA	5499	9	4	17	Show
GSE43470	PPP1CA	5499	6	1	36	Show
GSE46452	PPP1CA	5499	13	3	43	Show
GSE47630	PPP1CA	5499	8	5	27	Show
GSE54993	PPP1CA	5499	3	1	66	Show
GSE54994	PPP1CA	5499	13	4	36	Show
GSE60625	PPP1CA	5499	0	3	8	Show
GSE74703	PPP1CA	5499	4	0	32	Show
GSE74704	PPP1CA	5499	7	2	11	Show
TCGA	PPP1CA	5499	29	8	59	Show

Total number of gains: 101; Total number of losses: 35; Total Number of normals: 352.  Download Data

---

 

Somatic mutations of PPP1CA:

 

---

 

Highly correlated genes for PPP1CA:

 

Showing top 20/852 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
PPP1CA	CD22	0.823722	3	0	3
PPP1CA	MCTP2	0.786647	3	0	3
PPP1CA	COMMD2	0.783639	3	0	3
PPP1CA	SLC25A39	0.780018	7	0	7
PPP1CA	FANCD2	0.769703	4	0	3
PPP1CA	STON2	0.769084	3	0	3
PPP1CA	PDCD5	0.761056	3	0	3
PPP1CA	CHTOP	0.756946	3	0	3
PPP1CA	MRPL38	0.754683	5	0	5
PPP1CA	EFHD2	0.7526	3	0	3
PPP1CA	TRAF2	0.749361	3	0	3
PPP1CA	OTUB1	0.73949	4	0	4
PPP1CA	PTPN6	0.738501	3	0	3
PPP1CA	OIP5	0.732325	3	0	3
PPP1CA	MRPL30	0.730304	3	0	3
PPP1CA	RNF149	0.718697	3	0	3
PPP1CA	PRRC2A	0.716754	3	0	3
PPP1CA	OLFM2	0.715524	3	0	3
PPP1CA	MCCC2	0.713895	4	0	3
PPP1CA	PRELID1	0.710697	4	0	3

For details and further investigation, click here