| Full name: protein kinase N3 | Alias Symbol: PKNbeta|UTDP4-1 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 29941 | HGNC ID: HGNC:17999 | Ensembl Gene: ENSG00000160447 | OMIM ID: 610714 |
| Drug and gene relationship at DGIdb | |||
PKN3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa05132 | Salmonella infection |
Expression of PKN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKN3 | 29941 | 226299_at | 0.1843 | 0.6403 | |
| GSE26886 | PKN3 | 29941 | 226299_at | 0.7168 | 0.0000 | |
| GSE45670 | PKN3 | 29941 | 226299_at | 0.1443 | 0.3420 | |
| GSE53622 | PKN3 | 29941 | 40764 | 0.2318 | 0.0633 | |
| GSE53624 | PKN3 | 29941 | 40764 | 0.6795 | 0.0000 | |
| GSE63941 | PKN3 | 29941 | 226299_at | 0.9283 | 0.0532 | |
| GSE77861 | PKN3 | 29941 | 226299_at | 0.1518 | 0.2396 | |
| GSE97050 | PKN3 | 29941 | A_33_P3220202 | 0.3432 | 0.2444 | |
| SRP007169 | PKN3 | 29941 | RNAseq | 1.2994 | 0.0325 | |
| SRP064894 | PKN3 | 29941 | RNAseq | 0.7953 | 0.0006 | |
| SRP133303 | PKN3 | 29941 | RNAseq | -0.3097 | 0.0944 | |
| SRP159526 | PKN3 | 29941 | RNAseq | 1.0014 | 0.0002 | |
| SRP193095 | PKN3 | 29941 | RNAseq | 1.0459 | 0.0000 | |
| SRP219564 | PKN3 | 29941 | RNAseq | 0.0163 | 0.9654 | |
| TCGA | PKN3 | 29941 | RNAseq | 0.0830 | 0.3766 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PKN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKN3 | 29941 | 6 | 9 | 15 | |
| GSE20123 | PKN3 | 29941 | 6 | 9 | 15 | |
| GSE43470 | PKN3 | 29941 | 5 | 8 | 30 | |
| GSE46452 | PKN3 | 29941 | 6 | 13 | 40 | |
| GSE47630 | PKN3 | 29941 | 3 | 16 | 21 | |
| GSE54993 | PKN3 | 29941 | 3 | 3 | 64 | |
| GSE54994 | PKN3 | 29941 | 11 | 8 | 34 | |
| GSE60625 | PKN3 | 29941 | 0 | 0 | 11 | |
| GSE74703 | PKN3 | 29941 | 5 | 6 | 25 | |
| GSE74704 | PKN3 | 29941 | 3 | 7 | 10 | |
| TCGA | PKN3 | 29941 | 27 | 24 | 45 |
Total number of gains: 75; Total number of losses: 103; Total Number of normals: 310.
Somatic mutations of PKN3:
Generating mutation plots.
Highly correlated genes for PKN3:
Showing top 20/765 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKN3 | CBLB | 0.815692 | 3 | 0 | 3 |
| PKN3 | FAM89B | 0.786438 | 3 | 0 | 3 |
| PKN3 | GFPT2 | 0.781973 | 3 | 0 | 3 |
| PKN3 | TRPC1 | 0.771581 | 3 | 0 | 3 |
| PKN3 | LRCH3 | 0.753127 | 3 | 0 | 3 |
| PKN3 | UNC45A | 0.752175 | 3 | 0 | 3 |
| PKN3 | CDC42EP4 | 0.747122 | 3 | 0 | 3 |
| PKN3 | DOCK11 | 0.73829 | 3 | 0 | 3 |
| PKN3 | SGTB | 0.733315 | 3 | 0 | 3 |
| PKN3 | PET117 | 0.732856 | 3 | 0 | 3 |
| PKN3 | YIF1A | 0.732678 | 3 | 0 | 3 |
| PKN3 | FTO | 0.731163 | 3 | 0 | 3 |
| PKN3 | SNAPC4 | 0.72644 | 5 | 0 | 4 |
| PKN3 | ARV1 | 0.725449 | 3 | 0 | 3 |
| PKN3 | CHST15 | 0.720022 | 3 | 0 | 3 |
| PKN3 | NOP14 | 0.71617 | 3 | 0 | 3 |
| PKN3 | NGF | 0.715101 | 4 | 0 | 4 |
| PKN3 | PLOD1 | 0.714872 | 4 | 0 | 4 |
| PKN3 | CD151 | 0.713903 | 4 | 0 | 4 |
| PKN3 | LIX1L | 0.713679 | 3 | 0 | 3 |
For details and further investigation, click here
