| Full name: natriuretic peptide receptor 3 | Alias Symbol: GUCY2B|FLJ14054 | ||
| Type: protein-coding gene | Cytoband: 5p13.3 | ||
| Entrez ID: 4883 | HGNC ID: HGNC:7945 | Ensembl Gene: ENSG00000113389 | OMIM ID: 108962 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NPR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPR3 | 4883 | 219054_at | -0.8508 | 0.1225 | |
| GSE20347 | NPR3 | 4883 | 219789_at | -1.1825 | 0.0446 | |
| GSE23400 | NPR3 | 4883 | 219054_at | -0.1486 | 0.2498 | |
| GSE26886 | NPR3 | 4883 | 219054_at | -0.6294 | 0.0547 | |
| GSE29001 | NPR3 | 4883 | 219054_at | -0.9641 | 0.0102 | |
| GSE38129 | NPR3 | 4883 | 219054_at | -0.3255 | 0.2178 | |
| GSE45670 | NPR3 | 4883 | 219054_at | -0.6261 | 0.1185 | |
| GSE53622 | NPR3 | 4883 | 49759 | -1.1290 | 0.0001 | |
| GSE53624 | NPR3 | 4883 | 49759 | -1.1853 | 0.0000 | |
| GSE63941 | NPR3 | 4883 | 219054_at | -3.1324 | 0.0131 | |
| GSE77861 | NPR3 | 4883 | 219054_at | 0.1848 | 0.7259 | |
| GSE97050 | NPR3 | 4883 | A_23_P58676 | 0.2813 | 0.4335 | |
| SRP007169 | NPR3 | 4883 | RNAseq | -0.1722 | 0.8161 | |
| SRP008496 | NPR3 | 4883 | RNAseq | 0.2497 | 0.6375 | |
| SRP064894 | NPR3 | 4883 | RNAseq | -0.8878 | 0.0797 | |
| SRP133303 | NPR3 | 4883 | RNAseq | -0.1862 | 0.7708 | |
| SRP193095 | NPR3 | 4883 | RNAseq | -0.6800 | 0.1932 | |
| SRP219564 | NPR3 | 4883 | RNAseq | -1.0044 | 0.2562 | |
| TCGA | NPR3 | 4883 | RNAseq | 0.6644 | 0.0379 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by NPR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPR3 | 4883 | 11 | 0 | 19 | |
| GSE20123 | NPR3 | 4883 | 11 | 0 | 19 | |
| GSE43470 | NPR3 | 4883 | 15 | 3 | 25 | |
| GSE46452 | NPR3 | 4883 | 6 | 21 | 32 | |
| GSE47630 | NPR3 | 4883 | 6 | 12 | 22 | |
| GSE54993 | NPR3 | 4883 | 5 | 4 | 61 | |
| GSE54994 | NPR3 | 4883 | 26 | 2 | 25 | |
| GSE60625 | NPR3 | 4883 | 0 | 0 | 11 | |
| GSE74703 | NPR3 | 4883 | 12 | 2 | 22 | |
| GSE74704 | NPR3 | 4883 | 10 | 0 | 10 | |
| TCGA | NPR3 | 4883 | 51 | 6 | 39 |
Total number of gains: 153; Total number of losses: 50; Total Number of normals: 285.
Somatic mutations of NPR3:
Generating mutation plots.
Highly correlated genes for NPR3:
Showing top 20/70 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPR3 | GLIDR | 0.653114 | 3 | 0 | 3 |
| NPR3 | GBP6 | 0.607491 | 3 | 0 | 3 |
| NPR3 | SAMD5 | 0.600302 | 6 | 0 | 5 |
| NPR3 | DIO1 | 0.587334 | 3 | 0 | 3 |
| NPR3 | PPFIBP2 | 0.583045 | 7 | 0 | 5 |
| NPR3 | ROBO2 | 0.581795 | 5 | 0 | 5 |
| NPR3 | SOX21-AS1 | 0.57768 | 5 | 0 | 4 |
| NPR3 | RGMA | 0.577062 | 6 | 0 | 4 |
| NPR3 | SOX2 | 0.57469 | 9 | 0 | 6 |
| NPR3 | ZNF516 | 0.570514 | 5 | 0 | 4 |
| NPR3 | CTTNBP2 | 0.565752 | 6 | 0 | 5 |
| NPR3 | SUSD4 | 0.549616 | 7 | 0 | 4 |
| NPR3 | ARHGEF12 | 0.544942 | 5 | 0 | 3 |
| NPR3 | SLC9A9 | 0.544399 | 5 | 0 | 3 |
| NPR3 | PITX1 | 0.541472 | 8 | 0 | 4 |
| NPR3 | KLHDC8A | 0.53917 | 5 | 0 | 3 |
| NPR3 | FZD1 | 0.538572 | 3 | 0 | 3 |
| NPR3 | SLC16A14 | 0.53802 | 6 | 0 | 3 |
| NPR3 | CYP2C18 | 0.536677 | 9 | 0 | 5 |
| NPR3 | CYP2C9 | 0.5355 | 9 | 0 | 5 |
For details and further investigation, click here
