| Full name: bone morphogenetic protein 7 | Alias Symbol: OP-1 | ||
| Type: protein-coding gene | Cytoband: 20q13.31 | ||
| Entrez ID: 655 | HGNC ID: HGNC:1074 | Ensembl Gene: ENSG00000101144 | OMIM ID: 112267 |
| Drug and gene relationship at DGIdb | |||
BMP7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04360 | Axon guidance | |
| hsa04390 | Hippo signaling pathway |
Expression of BMP7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BMP7 | 655 | 209591_s_at | 1.4823 | 0.0132 | |
| GSE20347 | BMP7 | 655 | 209590_at | 0.1061 | 0.7214 | |
| GSE23400 | BMP7 | 655 | 209590_at | 0.1127 | 0.2885 | |
| GSE26886 | BMP7 | 655 | 209590_at | 0.0071 | 0.9797 | |
| GSE29001 | BMP7 | 655 | 209590_at | -0.0461 | 0.9133 | |
| GSE38129 | BMP7 | 655 | 209590_at | 0.2483 | 0.3964 | |
| GSE45670 | BMP7 | 655 | 209590_at | 0.1430 | 0.7428 | |
| GSE53622 | BMP7 | 655 | 95134 | 0.5819 | 0.0009 | |
| GSE53624 | BMP7 | 655 | 95134 | 0.3957 | 0.0025 | |
| GSE63941 | BMP7 | 655 | 209590_at | 1.5146 | 0.0439 | |
| GSE77861 | BMP7 | 655 | 209591_s_at | 0.7578 | 0.1219 | |
| GSE97050 | BMP7 | 655 | A_23_P154643 | -0.0616 | 0.7761 | |
| SRP007169 | BMP7 | 655 | RNAseq | -0.8132 | 0.0764 | |
| SRP008496 | BMP7 | 655 | RNAseq | -0.1347 | 0.6532 | |
| SRP064894 | BMP7 | 655 | RNAseq | 0.3976 | 0.3084 | |
| SRP133303 | BMP7 | 655 | RNAseq | 0.3423 | 0.3556 | |
| SRP159526 | BMP7 | 655 | RNAseq | 1.2695 | 0.0000 | |
| SRP193095 | BMP7 | 655 | RNAseq | 0.2804 | 0.3383 | |
| SRP219564 | BMP7 | 655 | RNAseq | 0.4025 | 0.4943 | |
| TCGA | BMP7 | 655 | RNAseq | 0.5203 | 0.0082 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by BMP7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BMP7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BMP7 | 655 | 14 | 2 | 14 | |
| GSE20123 | BMP7 | 655 | 14 | 2 | 14 | |
| GSE43470 | BMP7 | 655 | 13 | 0 | 30 | |
| GSE46452 | BMP7 | 655 | 29 | 0 | 30 | |
| GSE47630 | BMP7 | 655 | 24 | 1 | 15 | |
| GSE54993 | BMP7 | 655 | 0 | 18 | 52 | |
| GSE54994 | BMP7 | 655 | 29 | 0 | 24 | |
| GSE60625 | BMP7 | 655 | 0 | 0 | 11 | |
| GSE74703 | BMP7 | 655 | 11 | 0 | 25 | |
| GSE74704 | BMP7 | 655 | 11 | 0 | 9 | |
| TCGA | BMP7 | 655 | 43 | 5 | 48 |
Total number of gains: 188; Total number of losses: 28; Total Number of normals: 272.
Somatic mutations of BMP7:
Generating mutation plots.
Highly correlated genes for BMP7:
Showing top 20/305 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BMP7 | KIF18A | 0.728405 | 3 | 0 | 3 |
| BMP7 | RPS6KA1 | 0.699809 | 3 | 0 | 3 |
| BMP7 | PYGO2 | 0.695654 | 3 | 0 | 3 |
| BMP7 | TUBA1B | 0.680598 | 3 | 0 | 3 |
| BMP7 | U2SURP | 0.680281 | 3 | 0 | 3 |
| BMP7 | TRAF3 | 0.676734 | 3 | 0 | 3 |
| BMP7 | SNRNP48 | 0.676589 | 3 | 0 | 3 |
| BMP7 | PSMB4 | 0.672092 | 3 | 0 | 3 |
| BMP7 | YWHAG | 0.671477 | 3 | 0 | 3 |
| BMP7 | CABLES2 | 0.671439 | 4 | 0 | 3 |
| BMP7 | CUX1 | 0.668495 | 3 | 0 | 3 |
| BMP7 | UHRF1BP1 | 0.667878 | 3 | 0 | 3 |
| BMP7 | KCTD1 | 0.66621 | 3 | 0 | 3 |
| BMP7 | ZNF664 | 0.665017 | 4 | 0 | 4 |
| BMP7 | PUF60 | 0.663561 | 3 | 0 | 3 |
| BMP7 | PPP1R16A | 0.6607 | 3 | 0 | 3 |
| BMP7 | IGF2R | 0.659084 | 3 | 0 | 3 |
| BMP7 | CPNE8 | 0.650914 | 3 | 0 | 3 |
| BMP7 | DLX3 | 0.648048 | 3 | 0 | 3 |
| BMP7 | IPO9 | 0.647817 | 3 | 0 | 3 |
For details and further investigation, click here
