| Full name: unc-45 myosin chaperone A | Alias Symbol: SMAP-1|GC-UNC45 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 55898 | HGNC ID: HGNC:30594 | Ensembl Gene: ENSG00000140553 | OMIM ID: 611219 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UNC45A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UNC45A | 55898 | 221708_s_at | -0.0132 | 0.9869 | |
| GSE20347 | UNC45A | 55898 | 221708_s_at | -0.1301 | 0.1740 | |
| GSE23400 | UNC45A | 55898 | 221708_s_at | -0.1622 | 0.0040 | |
| GSE26886 | UNC45A | 55898 | 221708_s_at | -0.0737 | 0.6627 | |
| GSE29001 | UNC45A | 55898 | 221708_s_at | -0.0914 | 0.6734 | |
| GSE38129 | UNC45A | 55898 | 221708_s_at | -0.0962 | 0.4586 | |
| GSE45670 | UNC45A | 55898 | 221708_s_at | 0.0814 | 0.6559 | |
| GSE53622 | UNC45A | 55898 | 12964 | -0.2198 | 0.0005 | |
| GSE53624 | UNC45A | 55898 | 12964 | -0.1599 | 0.0010 | |
| GSE63941 | UNC45A | 55898 | 221708_s_at | -0.0293 | 0.9500 | |
| GSE77861 | UNC45A | 55898 | 221708_s_at | 0.0979 | 0.6903 | |
| GSE97050 | UNC45A | 55898 | A_24_P398950 | -0.2974 | 0.3888 | |
| SRP007169 | UNC45A | 55898 | RNAseq | -0.1365 | 0.6771 | |
| SRP008496 | UNC45A | 55898 | RNAseq | -0.2550 | 0.2516 | |
| SRP064894 | UNC45A | 55898 | RNAseq | 0.2204 | 0.1939 | |
| SRP133303 | UNC45A | 55898 | RNAseq | -0.1358 | 0.3428 | |
| SRP159526 | UNC45A | 55898 | RNAseq | 0.1355 | 0.5244 | |
| SRP193095 | UNC45A | 55898 | RNAseq | 0.1164 | 0.2947 | |
| SRP219564 | UNC45A | 55898 | RNAseq | -0.4753 | 0.2157 | |
| TCGA | UNC45A | 55898 | RNAseq | 0.0033 | 0.9425 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UNC45A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UNC45A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UNC45A | 55898 | 8 | 2 | 20 | |
| GSE20123 | UNC45A | 55898 | 8 | 2 | 20 | |
| GSE43470 | UNC45A | 55898 | 5 | 5 | 33 | |
| GSE46452 | UNC45A | 55898 | 3 | 7 | 49 | |
| GSE47630 | UNC45A | 55898 | 8 | 11 | 21 | |
| GSE54993 | UNC45A | 55898 | 4 | 6 | 60 | |
| GSE54994 | UNC45A | 55898 | 7 | 7 | 39 | |
| GSE60625 | UNC45A | 55898 | 4 | 0 | 7 | |
| GSE74703 | UNC45A | 55898 | 4 | 4 | 28 | |
| GSE74704 | UNC45A | 55898 | 4 | 2 | 14 | |
| TCGA | UNC45A | 55898 | 18 | 12 | 66 |
Total number of gains: 73; Total number of losses: 58; Total Number of normals: 357.
Somatic mutations of UNC45A:
Generating mutation plots.
Highly correlated genes for UNC45A:
Showing top 20/177 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UNC45A | NARS2 | 0.77347 | 3 | 0 | 3 |
| UNC45A | ELMOD3 | 0.762427 | 3 | 0 | 3 |
| UNC45A | GHDC | 0.756339 | 3 | 0 | 3 |
| UNC45A | PKN3 | 0.752175 | 3 | 0 | 3 |
| UNC45A | RNF26 | 0.74325 | 3 | 0 | 3 |
| UNC45A | BNIP2 | 0.736266 | 3 | 0 | 3 |
| UNC45A | NDUFA8 | 0.724594 | 3 | 0 | 3 |
| UNC45A | DOCK1 | 0.720776 | 3 | 0 | 3 |
| UNC45A | COLEC11 | 0.718867 | 3 | 0 | 3 |
| UNC45A | CUL1 | 0.717629 | 3 | 0 | 3 |
| UNC45A | ANKS6 | 0.714407 | 3 | 0 | 3 |
| UNC45A | MED9 | 0.712173 | 3 | 0 | 3 |
| UNC45A | PLCD3 | 0.711247 | 3 | 0 | 3 |
| UNC45A | AAAS | 0.706749 | 4 | 0 | 4 |
| UNC45A | SCARA3 | 0.706246 | 4 | 0 | 3 |
| UNC45A | SORBS3 | 0.699761 | 4 | 0 | 3 |
| UNC45A | GLUD1 | 0.693728 | 3 | 0 | 3 |
| UNC45A | PTPN9 | 0.686352 | 4 | 0 | 3 |
| UNC45A | IGFBP2 | 0.684455 | 3 | 0 | 3 |
| UNC45A | LPCAT2 | 0.681123 | 3 | 0 | 3 |
For details and further investigation, click here
