IKBKE

 

Full name: inhibitor of nuclear factor kappa B kinase subunit epsilon Alias Symbol: IKKE|IKK-i|KIAA0151
Type: protein-coding gene Cytoband: 1q32.1
Entrez ID: 9641 HGNC ID: HGNC:14552 Ensembl Gene: ENSG00000263528 OMIM ID: 605048
Drug and gene relationship at DGIdb

 

IKBKE involved pathways:

KEGG pathway Description View
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection

 

Expression of IKBKE:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IKBKE 9641 204549_at 0.3048 0.3328
GSE20347 IKBKE 9641 204549_at 0.0724 0.5988
GSE23400 IKBKE 9641 204549_at 0.0912 0.0678
GSE26886 IKBKE 9641 204549_at -0.3439 0.0325
GSE29001 IKBKE 9641 204549_at 0.0650 0.7781
GSE38129 IKBKE 9641 204549_at 0.0517 0.7203
GSE45670 IKBKE 9641 204549_at 0.4732 0.0006
GSE53622 IKBKE 9641 45291 0.1306 0.4220
GSE53624 IKBKE 9641 45291 0.0897 0.2365
GSE63941 IKBKE 9641 214398_s_at 0.3305 0.5418
GSE77861 IKBKE 9641 204549_at 0.0908 0.5509
GSE97050 IKBKE 9641 A_23_P887 0.9302 0.1998
SRP007169 IKBKE 9641 RNAseq -0.6598 0.2211
SRP064894 IKBKE 9641 RNAseq 0.5119 0.0189
SRP133303 IKBKE 9641 RNAseq 0.0975 0.6992
SRP159526 IKBKE 9641 RNAseq -0.2619 0.5537
SRP193095 IKBKE 9641 RNAseq 0.0627 0.6501
SRP219564 IKBKE 9641 RNAseq 0.0651 0.8988
TCGA IKBKE 9641 RNAseq 0.3671 0.0005

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IKBKE expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IKBKE:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IKBKE 9641 11 0 19
GSE20123 IKBKE 9641 11 0 19
GSE43470 IKBKE 9641 7 0 36
GSE46452 IKBKE 9641 3 1 55
GSE47630 IKBKE 9641 14 0 26
GSE54993 IKBKE 9641 0 6 64
GSE54994 IKBKE 9641 14 0 39
GSE60625 IKBKE 9641 0 0 11
GSE74703 IKBKE 9641 7 0 29
GSE74704 IKBKE 9641 5 0 15
TCGA IKBKE 9641 44 6 46

Total number of gains: 116; Total number of losses: 13; Total Number of normals: 359.  

 

Somatic mutations of IKBKE:

 

Generating mutation plots.

 

Highly correlated genes for IKBKE:

 

Showing top 20/305 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IKBKERENBP0.734454303
IKBKEE2F20.675676303
IKBKETMEM2120.673466303
IKBKEIL2RG0.651546505
IKBKESERPINB70.646221303
IKBKEFMNL10.643934403
IKBKENRG10.643788303
IKBKEDHCR70.643031303
IKBKEFOXRED20.639687404
IKBKECORO1B0.637095403
IKBKEKHDRBS20.629719303
IKBKEPRR110.628173403
IKBKEPRORY0.62815303
IKBKECKLF0.627344303
IKBKESREBF10.625026303
IKBKEMDK0.62448403
IKBKESLC4A110.621115303
IKBKEDBT0.621103303
IKBKEGPR1320.620828303
IKBKETMEM2140.620496504

For details and further investigation, click here