| Full name: 7-dehydrocholesterol reductase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 1717 | HGNC ID: HGNC:2860 | Ensembl Gene: ENSG00000172893 | OMIM ID: 602858 |
| Drug and gene relationship at DGIdb | |||
Expression of DHCR7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHCR7 | 1717 | 201791_s_at | 1.8205 | 0.0473 | |
| GSE20347 | DHCR7 | 1717 | 201791_s_at | 1.2600 | 0.0002 | |
| GSE23400 | DHCR7 | 1717 | 201790_s_at | 0.9340 | 0.0000 | |
| GSE26886 | DHCR7 | 1717 | 201791_s_at | 1.3748 | 0.0034 | |
| GSE29001 | DHCR7 | 1717 | 201791_s_at | 1.0452 | 0.0303 | |
| GSE38129 | DHCR7 | 1717 | 201791_s_at | 1.4561 | 0.0000 | |
| GSE45670 | DHCR7 | 1717 | 201791_s_at | 1.0728 | 0.0011 | |
| GSE53622 | DHCR7 | 1717 | 21871 | 1.1312 | 0.0000 | |
| GSE53624 | DHCR7 | 1717 | 21871 | 1.4358 | 0.0000 | |
| GSE63941 | DHCR7 | 1717 | 201790_s_at | 1.3315 | 0.2821 | |
| GSE77861 | DHCR7 | 1717 | 201791_s_at | 1.4061 | 0.0226 | |
| GSE97050 | DHCR7 | 1717 | A_23_P24444 | 1.1635 | 0.1769 | |
| SRP007169 | DHCR7 | 1717 | RNAseq | 0.5420 | 0.3224 | |
| SRP008496 | DHCR7 | 1717 | RNAseq | 1.3887 | 0.0599 | |
| SRP064894 | DHCR7 | 1717 | RNAseq | 0.5585 | 0.0318 | |
| SRP133303 | DHCR7 | 1717 | RNAseq | 2.8874 | 0.0000 | |
| SRP159526 | DHCR7 | 1717 | RNAseq | 4.5444 | 0.0000 | |
| SRP193095 | DHCR7 | 1717 | RNAseq | 1.4043 | 0.0000 | |
| SRP219564 | DHCR7 | 1717 | RNAseq | 2.1731 | 0.0028 | |
| TCGA | DHCR7 | 1717 | RNAseq | 0.4192 | 0.0002 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by DHCR7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHCR7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHCR7 | 1717 | 12 | 6 | 12 | |
| GSE20123 | DHCR7 | 1717 | 11 | 6 | 13 | |
| GSE43470 | DHCR7 | 1717 | 7 | 3 | 33 | |
| GSE46452 | DHCR7 | 1717 | 18 | 12 | 29 | |
| GSE47630 | DHCR7 | 1717 | 11 | 9 | 20 | |
| GSE54993 | DHCR7 | 1717 | 4 | 11 | 55 | |
| GSE54994 | DHCR7 | 1717 | 16 | 12 | 25 | |
| GSE60625 | DHCR7 | 1717 | 0 | 7 | 4 | |
| GSE74703 | DHCR7 | 1717 | 6 | 3 | 27 | |
| GSE74704 | DHCR7 | 1717 | 7 | 4 | 9 | |
| TCGA | DHCR7 | 1717 | 46 | 15 | 35 |
Total number of gains: 138; Total number of losses: 88; Total Number of normals: 262.
Somatic mutations of DHCR7:
Generating mutation plots.
Highly correlated genes for DHCR7:
Showing top 20/1109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHCR7 | SLC9A1 | 0.783401 | 3 | 0 | 3 |
| DHCR7 | ST6GAL1 | 0.736105 | 3 | 0 | 3 |
| DHCR7 | SYT7 | 0.713694 | 4 | 0 | 3 |
| DHCR7 | CXCR4 | 0.713177 | 3 | 0 | 3 |
| DHCR7 | NUF2 | 0.703114 | 7 | 0 | 7 |
| DHCR7 | MND1 | 0.701806 | 6 | 0 | 6 |
| DHCR7 | SLFN11 | 0.697204 | 3 | 0 | 3 |
| DHCR7 | CENPN | 0.693694 | 9 | 0 | 9 |
| DHCR7 | UCK2 | 0.68261 | 3 | 0 | 3 |
| DHCR7 | RHPN2 | 0.675923 | 3 | 0 | 3 |
| DHCR7 | HAS3 | 0.675061 | 4 | 0 | 4 |
| DHCR7 | BUB1 | 0.674197 | 9 | 0 | 9 |
| DHCR7 | DHRS13 | 0.673101 | 4 | 0 | 3 |
| DHCR7 | CAGE1 | 0.672786 | 4 | 0 | 3 |
| DHCR7 | RNF4 | 0.669131 | 3 | 0 | 3 |
| DHCR7 | SLC1A5 | 0.660348 | 7 | 0 | 5 |
| DHCR7 | UBE2J2 | 0.660279 | 3 | 0 | 3 |
| DHCR7 | LINC00888 | 0.659419 | 3 | 0 | 3 |
| DHCR7 | KNSTRN | 0.657839 | 5 | 0 | 4 |
| DHCR7 | TMEM177 | 0.656809 | 8 | 0 | 7 |
For details and further investigation, click here
