| Full name: serpin family B member 7 | Alias Symbol: MEGSIN | ||
| Type: protein-coding gene | Cytoband: 18q21.33 | ||
| Entrez ID: 8710 | HGNC ID: HGNC:13902 | Ensembl Gene: ENSG00000166396 | OMIM ID: 603357 |
| Drug and gene relationship at DGIdb | |||
Expression of SERPINB7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINB7 | 8710 | 206421_s_at | 0.9106 | 0.6508 | |
| GSE20347 | SERPINB7 | 8710 | 206421_s_at | -0.0461 | 0.8999 | |
| GSE23400 | SERPINB7 | 8710 | 206421_s_at | 0.1644 | 0.0748 | |
| GSE26886 | SERPINB7 | 8710 | 206421_s_at | -1.1027 | 0.0010 | |
| GSE29001 | SERPINB7 | 8710 | 206421_s_at | -0.4872 | 0.4009 | |
| GSE38129 | SERPINB7 | 8710 | 206421_s_at | 0.0931 | 0.7697 | |
| GSE45670 | SERPINB7 | 8710 | 206421_s_at | 1.2628 | 0.0147 | |
| GSE53622 | SERPINB7 | 8710 | 79057 | 0.7028 | 0.0044 | |
| GSE53624 | SERPINB7 | 8710 | 79057 | 0.2232 | 0.2225 | |
| GSE63941 | SERPINB7 | 8710 | 206421_s_at | 0.9491 | 0.3047 | |
| GSE77861 | SERPINB7 | 8710 | 206421_s_at | 0.6973 | 0.2605 | |
| GSE97050 | SERPINB7 | 8710 | A_23_P141802 | 0.8449 | 0.1657 | |
| SRP007169 | SERPINB7 | 8710 | RNAseq | -2.0729 | 0.0144 | |
| SRP008496 | SERPINB7 | 8710 | RNAseq | -1.3256 | 0.1885 | |
| SRP064894 | SERPINB7 | 8710 | RNAseq | -0.5068 | 0.3497 | |
| SRP133303 | SERPINB7 | 8710 | RNAseq | 1.3858 | 0.0101 | |
| SRP159526 | SERPINB7 | 8710 | RNAseq | 1.5572 | 0.0456 | |
| SRP193095 | SERPINB7 | 8710 | RNAseq | 0.6736 | 0.0982 | |
| SRP219564 | SERPINB7 | 8710 | RNAseq | 1.4016 | 0.1899 | |
| TCGA | SERPINB7 | 8710 | RNAseq | 1.6631 | 0.0001 |
Upregulated datasets: 4; Downregulated datasets: 2.
Survival by SERPINB7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINB7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINB7 | 8710 | 1 | 9 | 20 | |
| GSE20123 | SERPINB7 | 8710 | 1 | 9 | 20 | |
| GSE43470 | SERPINB7 | 8710 | 0 | 7 | 36 | |
| GSE46452 | SERPINB7 | 8710 | 1 | 26 | 32 | |
| GSE47630 | SERPINB7 | 8710 | 5 | 21 | 14 | |
| GSE54993 | SERPINB7 | 8710 | 9 | 0 | 61 | |
| GSE54994 | SERPINB7 | 8710 | 1 | 18 | 34 | |
| GSE60625 | SERPINB7 | 8710 | 0 | 4 | 7 | |
| GSE74703 | SERPINB7 | 8710 | 0 | 7 | 29 | |
| GSE74704 | SERPINB7 | 8710 | 1 | 6 | 13 | |
| TCGA | SERPINB7 | 8710 | 10 | 45 | 41 |
Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.
Somatic mutations of SERPINB7:
Generating mutation plots.
Highly correlated genes for SERPINB7:
Showing top 20/156 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINB7 | LIPG | 0.731616 | 3 | 0 | 3 |
| SERPINB7 | KIF3C | 0.691775 | 3 | 0 | 3 |
| SERPINB7 | TNFAIP2 | 0.691684 | 3 | 0 | 3 |
| SERPINB7 | ALPK2 | 0.689235 | 3 | 0 | 3 |
| SERPINB7 | IL2RA | 0.68725 | 3 | 0 | 3 |
| SERPINB7 | LMAN1 | 0.680537 | 4 | 0 | 3 |
| SERPINB7 | COX6B2 | 0.675584 | 3 | 0 | 3 |
| SERPINB7 | TDO2 | 0.674114 | 4 | 0 | 3 |
| SERPINB7 | ENC1 | 0.66775 | 4 | 0 | 3 |
| SERPINB7 | SLC36A1 | 0.666135 | 3 | 0 | 3 |
| SERPINB7 | EXOSC6 | 0.664892 | 3 | 0 | 3 |
| SERPINB7 | AKIRIN2 | 0.660157 | 3 | 0 | 3 |
| SERPINB7 | KRTDAP | 0.65894 | 6 | 0 | 5 |
| SERPINB7 | TUBB3 | 0.658071 | 3 | 0 | 3 |
| SERPINB7 | BDKRB1 | 0.652647 | 3 | 0 | 3 |
| SERPINB7 | IKBKE | 0.646221 | 3 | 0 | 3 |
| SERPINB7 | SLC16A1 | 0.645603 | 3 | 0 | 3 |
| SERPINB7 | ARHGAP17 | 0.641365 | 3 | 0 | 3 |
| SERPINB7 | SPRR2G | 0.63906 | 6 | 0 | 4 |
| SERPINB7 | SLC50A1 | 0.638693 | 4 | 0 | 3 |
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