| Full name: midkine | Alias Symbol: MK|FLJ27379 | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 4192 | HGNC ID: HGNC:6972 | Ensembl Gene: ENSG00000110492 | OMIM ID: 162096 |
| Drug and gene relationship at DGIdb | |||
Expression of MDK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MDK | 4192 | 209035_at | 0.8721 | 0.2772 | |
| GSE20347 | MDK | 4192 | 209035_at | 0.7636 | 0.0002 | |
| GSE23400 | MDK | 4192 | 209035_at | 0.6129 | 0.0000 | |
| GSE26886 | MDK | 4192 | 209035_at | 1.3621 | 0.0000 | |
| GSE29001 | MDK | 4192 | 209035_at | 0.4194 | 0.0345 | |
| GSE38129 | MDK | 4192 | 209035_at | 1.1046 | 0.0000 | |
| GSE45670 | MDK | 4192 | 209035_at | 0.3371 | 0.0267 | |
| GSE53622 | MDK | 4192 | 12571 | 1.5541 | 0.0000 | |
| GSE53624 | MDK | 4192 | 12571 | 1.3525 | 0.0000 | |
| GSE63941 | MDK | 4192 | 209035_at | 2.8110 | 0.0237 | |
| GSE77861 | MDK | 4192 | 209035_at | 0.7077 | 0.0472 | |
| GSE97050 | MDK | 4192 | A_23_P116235 | 0.8490 | 0.2332 | |
| SRP007169 | MDK | 4192 | RNAseq | 0.5032 | 0.1739 | |
| SRP008496 | MDK | 4192 | RNAseq | 0.9527 | 0.0308 | |
| SRP064894 | MDK | 4192 | RNAseq | 1.8137 | 0.0000 | |
| SRP133303 | MDK | 4192 | RNAseq | 1.4052 | 0.0000 | |
| SRP159526 | MDK | 4192 | RNAseq | 2.1371 | 0.0001 | |
| SRP193095 | MDK | 4192 | RNAseq | 0.6632 | 0.0907 | |
| SRP219564 | MDK | 4192 | RNAseq | 2.0914 | 0.0000 | |
| TCGA | MDK | 4192 | RNAseq | 0.4346 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by MDK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MDK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MDK | 4192 | 3 | 7 | 20 | |
| GSE20123 | MDK | 4192 | 3 | 6 | 21 | |
| GSE43470 | MDK | 4192 | 2 | 5 | 36 | |
| GSE46452 | MDK | 4192 | 8 | 5 | 46 | |
| GSE47630 | MDK | 4192 | 3 | 9 | 28 | |
| GSE54993 | MDK | 4192 | 3 | 0 | 67 | |
| GSE54994 | MDK | 4192 | 1 | 10 | 42 | |
| GSE60625 | MDK | 4192 | 0 | 0 | 11 | |
| GSE74703 | MDK | 4192 | 2 | 2 | 32 | |
| GSE74704 | MDK | 4192 | 2 | 4 | 14 | |
| TCGA | MDK | 4192 | 15 | 19 | 62 |
Total number of gains: 42; Total number of losses: 67; Total Number of normals: 379.
Somatic mutations of MDK:
Generating mutation plots.
Highly correlated genes for MDK:
Showing top 20/885 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MDK | CTHRC1 | 0.733284 | 5 | 0 | 5 |
| MDK | KLHDC7B | 0.712429 | 5 | 0 | 4 |
| MDK | HELZ | 0.705778 | 4 | 0 | 4 |
| MDK | NOP14 | 0.701923 | 3 | 0 | 3 |
| MDK | PIM3 | 0.701077 | 3 | 0 | 3 |
| MDK | CDCA7 | 0.699974 | 4 | 0 | 4 |
| MDK | IL4I1 | 0.687344 | 7 | 0 | 5 |
| MDK | TP53I13 | 0.683005 | 5 | 0 | 5 |
| MDK | SSBP4 | 0.682139 | 4 | 0 | 4 |
| MDK | USP41 | 0.682128 | 3 | 0 | 3 |
| MDK | TFAP2A | 0.676432 | 3 | 0 | 3 |
| MDK | PXYLP1 | 0.674151 | 5 | 0 | 5 |
| MDK | C4orf48 | 0.668644 | 7 | 0 | 6 |
| MDK | TSEN54 | 0.668562 | 4 | 0 | 4 |
| MDK | ESCO2 | 0.666859 | 4 | 0 | 4 |
| MDK | CFB | 0.664389 | 4 | 0 | 3 |
| MDK | SDK1 | 0.663501 | 5 | 0 | 5 |
| MDK | WDR81 | 0.659201 | 4 | 0 | 3 |
| MDK | TXNDC12 | 0.656293 | 5 | 0 | 4 |
| MDK | CIC | 0.65581 | 4 | 0 | 3 |
For details and further investigation, click here
