| Full name: homogentisate 1,2-dioxygenase | Alias Symbol: HGO | ||
| Type: protein-coding gene | Cytoband: 3q13.33 | ||
| Entrez ID: 3081 | HGNC ID: HGNC:4892 | Ensembl Gene: ENSG00000113924 | OMIM ID: 607474 |
| Drug and gene relationship at DGIdb | |||
Expression of HGD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HGD | 3081 | 214308_s_at | 0.1061 | 0.6299 | |
| GSE20347 | HGD | 3081 | 214308_s_at | 0.0576 | 0.4310 | |
| GSE23400 | HGD | 3081 | 214308_s_at | -0.0113 | 0.7737 | |
| GSE26886 | HGD | 3081 | 214308_s_at | 0.4038 | 0.0066 | |
| GSE29001 | HGD | 3081 | 205221_at | -0.0167 | 0.9018 | |
| GSE38129 | HGD | 3081 | 214308_s_at | -0.0481 | 0.6549 | |
| GSE45670 | HGD | 3081 | 205221_at | 0.1845 | 0.0605 | |
| GSE53622 | HGD | 3081 | 59299 | -0.2930 | 0.0100 | |
| GSE53624 | HGD | 3081 | 59299 | -0.1827 | 0.1010 | |
| GSE63941 | HGD | 3081 | 214308_s_at | 0.2515 | 0.4056 | |
| GSE77861 | HGD | 3081 | 214308_s_at | 0.0463 | 0.7139 | |
| GSE97050 | HGD | 3081 | A_23_P250164 | 0.0712 | 0.7674 | |
| TCGA | HGD | 3081 | RNAseq | -3.4722 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HGD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HGD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HGD | 3081 | 18 | 0 | 12 | |
| GSE20123 | HGD | 3081 | 18 | 0 | 12 | |
| GSE43470 | HGD | 3081 | 21 | 1 | 21 | |
| GSE46452 | HGD | 3081 | 14 | 5 | 40 | |
| GSE47630 | HGD | 3081 | 16 | 5 | 19 | |
| GSE54993 | HGD | 3081 | 2 | 6 | 62 | |
| GSE54994 | HGD | 3081 | 30 | 4 | 19 | |
| GSE60625 | HGD | 3081 | 0 | 6 | 5 | |
| GSE74703 | HGD | 3081 | 17 | 1 | 18 | |
| GSE74704 | HGD | 3081 | 13 | 0 | 7 | |
| TCGA | HGD | 3081 | 53 | 7 | 36 |
Total number of gains: 202; Total number of losses: 35; Total Number of normals: 251.
Somatic mutations of HGD:
Generating mutation plots.
Highly correlated genes for HGD:
Showing top 20/625 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HGD | IL22RA2 | 0.836938 | 3 | 0 | 3 |
| HGD | ZMYND15 | 0.82098 | 3 | 0 | 3 |
| HGD | CLCNKA | 0.801956 | 3 | 0 | 3 |
| HGD | PINX1 | 0.775501 | 3 | 0 | 3 |
| HGD | CDC42EP2 | 0.770517 | 3 | 0 | 3 |
| HGD | TMEM229A | 0.75594 | 3 | 0 | 3 |
| HGD | PRKAR1B | 0.751031 | 3 | 0 | 3 |
| HGD | PIP5KL1 | 0.744685 | 3 | 0 | 3 |
| HGD | LRFN1 | 0.739347 | 3 | 0 | 3 |
| HGD | ZNF341 | 0.72708 | 3 | 0 | 3 |
| HGD | ARSA | 0.719294 | 3 | 0 | 3 |
| HGD | DNLZ | 0.719107 | 3 | 0 | 3 |
| HGD | GCM2 | 0.716562 | 3 | 0 | 3 |
| HGD | HDAC10 | 0.709828 | 3 | 0 | 3 |
| HGD | TDGF1 | 0.708968 | 3 | 0 | 3 |
| HGD | C16orf95 | 0.708372 | 3 | 0 | 3 |
| HGD | TCTEX1D4 | 0.708076 | 4 | 0 | 3 |
| HGD | RPP25 | 0.701882 | 4 | 0 | 3 |
| HGD | SEC14L4 | 0.693206 | 4 | 0 | 4 |
| HGD | CELF3 | 0.692626 | 6 | 0 | 5 |
For details and further investigation, click here
