| Full name: transcriptional repressor GATA binding 1 | Alias Symbol: LGCR|GC79 | ||
| Type: protein-coding gene | Cytoband: 8q23.3 | ||
| Entrez ID: 7227 | HGNC ID: HGNC:12340 | Ensembl Gene: ENSG00000104447 | OMIM ID: 604386 |
| Drug and gene relationship at DGIdb | |||
Expression of TRPS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPS1 | 7227 | 222651_s_at | -0.0778 | 0.9537 | |
| GSE20347 | TRPS1 | 7227 | 218502_s_at | -1.3429 | 0.0000 | |
| GSE23400 | TRPS1 | 7227 | 218502_s_at | -0.7844 | 0.0000 | |
| GSE26886 | TRPS1 | 7227 | 222651_s_at | -0.9377 | 0.0003 | |
| GSE29001 | TRPS1 | 7227 | 218502_s_at | -1.1450 | 0.0118 | |
| GSE38129 | TRPS1 | 7227 | 218502_s_at | -1.0350 | 0.0001 | |
| GSE45670 | TRPS1 | 7227 | 222651_s_at | -0.7566 | 0.0017 | |
| GSE53622 | TRPS1 | 7227 | 91330 | -0.9753 | 0.0000 | |
| GSE53624 | TRPS1 | 7227 | 91330 | -1.2052 | 0.0000 | |
| GSE63941 | TRPS1 | 7227 | 222651_s_at | -0.0398 | 0.9659 | |
| GSE77861 | TRPS1 | 7227 | 222651_s_at | -0.4635 | 0.2528 | |
| GSE97050 | TRPS1 | 7227 | A_23_P134755 | -0.4870 | 0.2084 | |
| SRP007169 | TRPS1 | 7227 | RNAseq | -1.2518 | 0.0002 | |
| SRP008496 | TRPS1 | 7227 | RNAseq | -1.0431 | 0.0000 | |
| SRP064894 | TRPS1 | 7227 | RNAseq | -0.9790 | 0.0000 | |
| SRP133303 | TRPS1 | 7227 | RNAseq | -0.9549 | 0.0001 | |
| SRP159526 | TRPS1 | 7227 | RNAseq | -0.8754 | 0.0671 | |
| SRP193095 | TRPS1 | 7227 | RNAseq | -0.7727 | 0.0084 | |
| SRP219564 | TRPS1 | 7227 | RNAseq | -0.5525 | 0.2572 | |
| TCGA | TRPS1 | 7227 | RNAseq | 0.2513 | 0.0192 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by TRPS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPS1 | 7227 | 17 | 0 | 13 | |
| GSE20123 | TRPS1 | 7227 | 18 | 0 | 12 | |
| GSE43470 | TRPS1 | 7227 | 22 | 0 | 21 | |
| GSE46452 | TRPS1 | 7227 | 26 | 0 | 33 | |
| GSE47630 | TRPS1 | 7227 | 24 | 0 | 16 | |
| GSE54993 | TRPS1 | 7227 | 0 | 20 | 50 | |
| GSE54994 | TRPS1 | 7227 | 37 | 1 | 15 | |
| GSE60625 | TRPS1 | 7227 | 0 | 4 | 7 | |
| GSE74703 | TRPS1 | 7227 | 19 | 0 | 17 | |
| GSE74704 | TRPS1 | 7227 | 12 | 0 | 8 | |
| TCGA | TRPS1 | 7227 | 64 | 2 | 30 |
Total number of gains: 239; Total number of losses: 27; Total Number of normals: 222.
Somatic mutations of TRPS1:
Generating mutation plots.
Highly correlated genes for TRPS1:
Showing top 20/400 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPS1 | UBN2 | 0.738046 | 3 | 0 | 3 |
| TRPS1 | CTTNBP2 | 0.710297 | 6 | 0 | 5 |
| TRPS1 | FAM163B | 0.701168 | 3 | 0 | 3 |
| TRPS1 | A2ML1 | 0.698886 | 4 | 0 | 4 |
| TRPS1 | FAM214A | 0.692237 | 4 | 0 | 4 |
| TRPS1 | SAMD5 | 0.681417 | 4 | 0 | 4 |
| TRPS1 | SH3BGRL2 | 0.674569 | 5 | 0 | 4 |
| TRPS1 | SPINK7 | 0.672387 | 5 | 0 | 5 |
| TRPS1 | TFAP2B | 0.670068 | 8 | 0 | 7 |
| TRPS1 | SHROOM3 | 0.669604 | 5 | 0 | 5 |
| TRPS1 | SMDT1 | 0.669397 | 3 | 0 | 3 |
| TRPS1 | KLKB1 | 0.667023 | 4 | 0 | 4 |
| TRPS1 | PDZD2 | 0.665963 | 11 | 0 | 10 |
| TRPS1 | IL22RA2 | 0.665098 | 3 | 0 | 3 |
| TRPS1 | B3GNT8 | 0.66267 | 4 | 0 | 3 |
| TRPS1 | CRISP3 | 0.659969 | 8 | 0 | 8 |
| TRPS1 | ALDH9A1 | 0.659614 | 9 | 0 | 9 |
| TRPS1 | KIAA0232 | 0.655336 | 11 | 0 | 10 |
| TRPS1 | KLB | 0.654918 | 4 | 0 | 4 |
| TRPS1 | UBL3 | 0.649539 | 9 | 0 | 8 |
For details and further investigation, click here
