| Full name: inhibitor of growth family member 3 | Alias Symbol: p47ING3|FLJ20089|Eaf4|MEAF4 | ||
| Type: protein-coding gene | Cytoband: 7q31.31 | ||
| Entrez ID: 54556 | HGNC ID: HGNC:14587 | Ensembl Gene: ENSG00000071243 | OMIM ID: 607493 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ING3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ING3 | 54556 | 205070_at | -0.1994 | 0.8412 | |
| GSE20347 | ING3 | 54556 | 205070_at | 0.2935 | 0.1381 | |
| GSE23400 | ING3 | 54556 | 205070_at | 0.0990 | 0.1621 | |
| GSE26886 | ING3 | 54556 | 205070_at | -0.6179 | 0.1252 | |
| GSE29001 | ING3 | 54556 | 205070_at | 0.1432 | 0.6038 | |
| GSE38129 | ING3 | 54556 | 205070_at | -0.0017 | 0.9945 | |
| GSE45670 | ING3 | 54556 | 205070_at | -0.0610 | 0.8640 | |
| GSE53622 | ING3 | 54556 | 50729 | -0.6057 | 0.0000 | |
| GSE53624 | ING3 | 54556 | 50729 | -0.1775 | 0.0220 | |
| GSE63941 | ING3 | 54556 | 205070_at | -0.1452 | 0.8496 | |
| GSE77861 | ING3 | 54556 | 205070_at | 0.4668 | 0.0934 | |
| GSE97050 | ING3 | 54556 | A_23_P111811 | -0.5605 | 0.1466 | |
| SRP007169 | ING3 | 54556 | RNAseq | -0.1127 | 0.7635 | |
| SRP008496 | ING3 | 54556 | RNAseq | 0.1283 | 0.6998 | |
| SRP064894 | ING3 | 54556 | RNAseq | -0.0870 | 0.6565 | |
| SRP133303 | ING3 | 54556 | RNAseq | 0.0032 | 0.9859 | |
| SRP159526 | ING3 | 54556 | RNAseq | 0.0399 | 0.8668 | |
| SRP193095 | ING3 | 54556 | RNAseq | -0.3376 | 0.0148 | |
| SRP219564 | ING3 | 54556 | RNAseq | -0.3342 | 0.2338 | |
| TCGA | ING3 | 54556 | RNAseq | -0.2902 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ING3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ING3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ING3 | 54556 | 6 | 2 | 22 | |
| GSE20123 | ING3 | 54556 | 7 | 2 | 21 | |
| GSE43470 | ING3 | 54556 | 3 | 3 | 37 | |
| GSE46452 | ING3 | 54556 | 8 | 1 | 50 | |
| GSE47630 | ING3 | 54556 | 7 | 4 | 29 | |
| GSE54993 | ING3 | 54556 | 2 | 6 | 62 | |
| GSE54994 | ING3 | 54556 | 10 | 6 | 37 | |
| GSE60625 | ING3 | 54556 | 0 | 0 | 11 | |
| GSE74703 | ING3 | 54556 | 3 | 3 | 30 | |
| GSE74704 | ING3 | 54556 | 5 | 2 | 13 | |
| TCGA | ING3 | 54556 | 28 | 20 | 48 |
Total number of gains: 79; Total number of losses: 49; Total Number of normals: 360.
Somatic mutations of ING3:
Generating mutation plots.
Highly correlated genes for ING3:
Showing top 20/397 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ING3 | SELENBP1 | 0.816303 | 3 | 0 | 3 |
| ING3 | WDR48 | 0.769924 | 3 | 0 | 3 |
| ING3 | ARHGEF9 | 0.750598 | 3 | 0 | 3 |
| ING3 | ZXDA | 0.741623 | 3 | 0 | 3 |
| ING3 | KLHL15 | 0.737531 | 3 | 0 | 3 |
| ING3 | CENPV | 0.733248 | 3 | 0 | 3 |
| ING3 | CTDSPL | 0.729379 | 4 | 0 | 4 |
| ING3 | FRAT1 | 0.729294 | 3 | 0 | 3 |
| ING3 | TXNIP | 0.728517 | 3 | 0 | 3 |
| ING3 | ANGPTL1 | 0.720541 | 3 | 0 | 3 |
| ING3 | ANTXR2 | 0.716426 | 3 | 0 | 3 |
| ING3 | ZNF615 | 0.708851 | 4 | 0 | 4 |
| ING3 | CDC26 | 0.708059 | 3 | 0 | 3 |
| ING3 | FRMD3 | 0.707011 | 4 | 0 | 4 |
| ING3 | TMEM140 | 0.704776 | 3 | 0 | 3 |
| ING3 | RASL12 | 0.703654 | 3 | 0 | 3 |
| ING3 | C2orf88 | 0.699609 | 3 | 0 | 3 |
| ING3 | RFX2 | 0.699292 | 3 | 0 | 3 |
| ING3 | PCGF5 | 0.698187 | 4 | 0 | 4 |
| ING3 | ZNF383 | 0.694464 | 4 | 0 | 4 |
For details and further investigation, click here
