| Full name: cell division cycle 26 | Alias Symbol: APC12|ANAPC12 | ||
| Type: protein-coding gene | Cytoband: 9q32 | ||
| Entrez ID: 246184 | HGNC ID: HGNC:17839 | Ensembl Gene: ENSG00000176386 | OMIM ID: 614533 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CDC26 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation | |
| hsa05166 | HTLV-I infection |
Expression of CDC26:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDC26 | 246184 | 225422_at | -0.2429 | 0.5622 | |
| GSE26886 | CDC26 | 246184 | 225422_at | 0.2494 | 0.2627 | |
| GSE45670 | CDC26 | 246184 | 225422_at | -0.0273 | 0.8777 | |
| GSE53622 | CDC26 | 246184 | 156597 | 0.1296 | 0.0436 | |
| GSE53624 | CDC26 | 246184 | 156597 | 0.2141 | 0.0130 | |
| GSE63941 | CDC26 | 246184 | 225422_at | 0.2652 | 0.4421 | |
| GSE77861 | CDC26 | 246184 | 225422_at | 0.2056 | 0.4878 | |
| GSE97050 | CDC26 | 246184 | A_32_P228501 | 0.1014 | 0.7509 | |
| SRP007169 | CDC26 | 246184 | RNAseq | 0.0060 | 0.9882 | |
| SRP008496 | CDC26 | 246184 | RNAseq | 0.2933 | 0.2834 | |
| SRP064894 | CDC26 | 246184 | RNAseq | 0.7422 | 0.0194 | |
| SRP133303 | CDC26 | 246184 | RNAseq | 0.2051 | 0.1737 | |
| SRP159526 | CDC26 | 246184 | RNAseq | 0.4505 | 0.1069 | |
| SRP193095 | CDC26 | 246184 | RNAseq | -0.1138 | 0.4281 | |
| SRP219564 | CDC26 | 246184 | RNAseq | -0.1586 | 0.6603 | |
| TCGA | CDC26 | 246184 | RNAseq | -0.6829 | 0.5753 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDC26 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDC26:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDC26 | 246184 | 5 | 10 | 15 | |
| GSE20123 | CDC26 | 246184 | 5 | 10 | 15 | |
| GSE43470 | CDC26 | 246184 | 4 | 3 | 36 | |
| GSE46452 | CDC26 | 246184 | 6 | 13 | 40 | |
| GSE47630 | CDC26 | 246184 | 3 | 16 | 21 | |
| GSE54993 | CDC26 | 246184 | 3 | 3 | 64 | |
| GSE54994 | CDC26 | 246184 | 9 | 10 | 34 | |
| GSE60625 | CDC26 | 246184 | 0 | 0 | 11 | |
| GSE74703 | CDC26 | 246184 | 4 | 3 | 29 | |
| GSE74704 | CDC26 | 246184 | 2 | 8 | 10 | |
| TCGA | CDC26 | 246184 | 26 | 22 | 48 |
Total number of gains: 67; Total number of losses: 98; Total Number of normals: 323.
Somatic mutations of CDC26:
Generating mutation plots.
Highly correlated genes for CDC26:
Showing top 20/333 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDC26 | SLC25A3 | 0.819226 | 3 | 0 | 3 |
| CDC26 | RPL41 | 0.7951 | 3 | 0 | 3 |
| CDC26 | NDUFB2 | 0.790844 | 3 | 0 | 3 |
| CDC26 | PNKD | 0.785259 | 3 | 0 | 3 |
| CDC26 | NSMCE4A | 0.782839 | 3 | 0 | 3 |
| CDC26 | SPATA6 | 0.767164 | 3 | 0 | 3 |
| CDC26 | OCEL1 | 0.766506 | 3 | 0 | 3 |
| CDC26 | FIS1 | 0.76223 | 3 | 0 | 3 |
| CDC26 | PSMA5 | 0.759688 | 3 | 0 | 3 |
| CDC26 | MMRN2 | 0.757135 | 3 | 0 | 3 |
| CDC26 | ING4 | 0.753849 | 3 | 0 | 3 |
| CDC26 | ZNF136 | 0.74624 | 3 | 0 | 3 |
| CDC26 | IFNAR1 | 0.741334 | 3 | 0 | 3 |
| CDC26 | AKAP7 | 0.737849 | 3 | 0 | 3 |
| CDC26 | ATG4C | 0.734898 | 3 | 0 | 3 |
| CDC26 | SLC25A24 | 0.732783 | 3 | 0 | 3 |
| CDC26 | KBTBD2 | 0.732033 | 3 | 0 | 3 |
| CDC26 | PPP3CB | 0.730384 | 3 | 0 | 3 |
| CDC26 | SMARCE1 | 0.729314 | 4 | 0 | 3 |
| CDC26 | TXNDC16 | 0.728608 | 3 | 0 | 3 |
For details and further investigation, click here
