| Full name: thioredoxin interacting protein | Alias Symbol: VDUP1|EST01027|HHCPA78|THIF|ARRDC6 | ||
| Type: protein-coding gene | Cytoband: 1q21.1 | ||
| Entrez ID: 10628 | HGNC ID: HGNC:16952 | Ensembl Gene: ENSG00000265972 | OMIM ID: 606599 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TXNIP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TXNIP | 10628 | 201010_s_at | -0.9160 | 0.3210 | |
| GSE20347 | TXNIP | 10628 | 201009_s_at | -0.2335 | 0.4578 | |
| GSE23400 | TXNIP | 10628 | 201010_s_at | -0.5606 | 0.0001 | |
| GSE26886 | TXNIP | 10628 | 201010_s_at | -0.7486 | 0.1678 | |
| GSE29001 | TXNIP | 10628 | 201010_s_at | -0.5145 | 0.0679 | |
| GSE38129 | TXNIP | 10628 | 201010_s_at | -0.7049 | 0.0147 | |
| GSE45670 | TXNIP | 10628 | 201010_s_at | -1.4004 | 0.0015 | |
| GSE53622 | TXNIP | 10628 | 6395 | -1.1005 | 0.0000 | |
| GSE53624 | TXNIP | 10628 | 6395 | -1.0797 | 0.0000 | |
| GSE63941 | TXNIP | 10628 | 201010_s_at | 0.4120 | 0.8221 | |
| GSE77861 | TXNIP | 10628 | 201010_s_at | -1.0381 | 0.1265 | |
| GSE97050 | TXNIP | 10628 | A_23_P97700 | -1.6664 | 0.0555 | |
| SRP007169 | TXNIP | 10628 | RNAseq | -0.2914 | 0.4994 | |
| SRP008496 | TXNIP | 10628 | RNAseq | 0.1028 | 0.7396 | |
| SRP064894 | TXNIP | 10628 | RNAseq | -0.5356 | 0.0918 | |
| SRP133303 | TXNIP | 10628 | RNAseq | -0.3232 | 0.2648 | |
| SRP159526 | TXNIP | 10628 | RNAseq | 0.0606 | 0.9309 | |
| SRP193095 | TXNIP | 10628 | RNAseq | -0.6231 | 0.0072 | |
| SRP219564 | TXNIP | 10628 | RNAseq | -0.4983 | 0.2719 | |
| TCGA | TXNIP | 10628 | RNAseq | -0.5056 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TXNIP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TXNIP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TXNIP | 10628 | 13 | 0 | 17 | |
| GSE20123 | TXNIP | 10628 | 13 | 0 | 17 | |
| GSE43470 | TXNIP | 10628 | 5 | 2 | 36 | |
| GSE46452 | TXNIP | 10628 | 2 | 1 | 56 | |
| GSE47630 | TXNIP | 10628 | 12 | 2 | 26 | |
| GSE54993 | TXNIP | 10628 | 0 | 2 | 68 | |
| GSE54994 | TXNIP | 10628 | 15 | 0 | 38 | |
| GSE60625 | TXNIP | 10628 | 0 | 0 | 11 | |
| GSE74703 | TXNIP | 10628 | 5 | 2 | 29 | |
| GSE74704 | TXNIP | 10628 | 6 | 0 | 14 | |
| TCGA | TXNIP | 10628 | 33 | 15 | 48 |
Total number of gains: 104; Total number of losses: 24; Total Number of normals: 360.
Somatic mutations of TXNIP:
Generating mutation plots.
Highly correlated genes for TXNIP:
Showing top 20/1082 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TXNIP | MACROD2 | 0.830898 | 3 | 0 | 3 |
| TXNIP | CYP4V2 | 0.813769 | 3 | 0 | 3 |
| TXNIP | CEP44 | 0.806791 | 3 | 0 | 3 |
| TXNIP | CLEC3B | 0.799792 | 3 | 0 | 3 |
| TXNIP | HNRNPA0 | 0.797674 | 3 | 0 | 3 |
| TXNIP | ANGPTL1 | 0.782485 | 5 | 0 | 5 |
| TXNIP | KCNB1 | 0.777211 | 4 | 0 | 4 |
| TXNIP | MAMDC2 | 0.753305 | 5 | 0 | 5 |
| TXNIP | PARD3B | 0.753263 | 4 | 0 | 4 |
| TXNIP | SORCS1 | 0.751673 | 4 | 0 | 4 |
| TXNIP | RAB9B | 0.748979 | 5 | 0 | 5 |
| TXNIP | KDM5D | 0.746776 | 3 | 0 | 3 |
| TXNIP | CYP21A2 | 0.742337 | 3 | 0 | 3 |
| TXNIP | TNS1 | 0.740549 | 7 | 0 | 7 |
| TXNIP | GNPDA2 | 0.739661 | 4 | 0 | 4 |
| TXNIP | MRVI1 | 0.739095 | 5 | 0 | 4 |
| TXNIP | ITGA9 | 0.738055 | 5 | 0 | 5 |
| TXNIP | ZNF441 | 0.73285 | 6 | 0 | 6 |
| TXNIP | NKAPL | 0.729971 | 4 | 0 | 4 |
| TXNIP | ING3 | 0.728517 | 3 | 0 | 3 |
For details and further investigation, click here
