| Full name: inositol polyphosphate-5-phosphatase K | Alias Symbol: SKIP | ||
| Type: protein-coding gene | Cytoband: 17p13.3 | ||
| Entrez ID: 51763 | HGNC ID: HGNC:33882 | Ensembl Gene: ENSG00000132376 | OMIM ID: 607875 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
INPP5K involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway |
Expression of INPP5K:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INPP5K | 51763 | 202782_s_at | 0.1083 | 0.6440 | |
| GSE20347 | INPP5K | 51763 | 202782_s_at | 0.0014 | 0.9899 | |
| GSE23400 | INPP5K | 51763 | 202782_s_at | -0.1278 | 0.0036 | |
| GSE26886 | INPP5K | 51763 | 202782_s_at | 0.0210 | 0.8930 | |
| GSE29001 | INPP5K | 51763 | 202782_s_at | -0.1395 | 0.3313 | |
| GSE38129 | INPP5K | 51763 | 202782_s_at | -0.0693 | 0.3004 | |
| GSE45670 | INPP5K | 51763 | 202782_s_at | 0.1489 | 0.1609 | |
| GSE53622 | INPP5K | 51763 | 5110 | -0.2203 | 0.0000 | |
| GSE53624 | INPP5K | 51763 | 5110 | 0.0202 | 0.7255 | |
| GSE63941 | INPP5K | 51763 | 202781_s_at | 1.1301 | 0.0066 | |
| GSE77861 | INPP5K | 51763 | 202782_s_at | 0.0460 | 0.8364 | |
| GSE97050 | INPP5K | 51763 | A_33_P3318911 | -0.1309 | 0.5364 | |
| SRP007169 | INPP5K | 51763 | RNAseq | -1.1348 | 0.0022 | |
| SRP008496 | INPP5K | 51763 | RNAseq | -0.9240 | 0.0001 | |
| SRP064894 | INPP5K | 51763 | RNAseq | 0.1154 | 0.5232 | |
| SRP133303 | INPP5K | 51763 | RNAseq | -0.3063 | 0.0095 | |
| SRP159526 | INPP5K | 51763 | RNAseq | -0.1227 | 0.4561 | |
| SRP193095 | INPP5K | 51763 | RNAseq | 0.0760 | 0.4409 | |
| SRP219564 | INPP5K | 51763 | RNAseq | 0.0520 | 0.8093 | |
| TCGA | INPP5K | 51763 | RNAseq | -0.0743 | 0.1415 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by INPP5K expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INPP5K:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INPP5K | 51763 | 5 | 2 | 23 | |
| GSE20123 | INPP5K | 51763 | 5 | 3 | 22 | |
| GSE43470 | INPP5K | 51763 | 3 | 6 | 34 | |
| GSE46452 | INPP5K | 51763 | 34 | 1 | 24 | |
| GSE47630 | INPP5K | 51763 | 8 | 1 | 31 | |
| GSE54993 | INPP5K | 51763 | 9 | 3 | 58 | |
| GSE54994 | INPP5K | 51763 | 7 | 9 | 37 | |
| GSE60625 | INPP5K | 51763 | 4 | 0 | 7 | |
| GSE74703 | INPP5K | 51763 | 2 | 3 | 31 | |
| GSE74704 | INPP5K | 51763 | 3 | 1 | 16 | |
| TCGA | INPP5K | 51763 | 18 | 21 | 57 |
Total number of gains: 98; Total number of losses: 50; Total Number of normals: 340.
Somatic mutations of INPP5K:
Generating mutation plots.
Highly correlated genes for INPP5K:
Showing top 20/213 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INPP5K | GATC | 0.784309 | 3 | 0 | 3 |
| INPP5K | VPS72 | 0.761373 | 3 | 0 | 3 |
| INPP5K | ZNF766 | 0.749994 | 3 | 0 | 3 |
| INPP5K | TRAPPC1 | 0.742244 | 3 | 0 | 3 |
| INPP5K | SDAD1 | 0.737852 | 3 | 0 | 3 |
| INPP5K | ALKBH7 | 0.727921 | 3 | 0 | 3 |
| INPP5K | ERI3 | 0.723362 | 3 | 0 | 3 |
| INPP5K | TIMM9 | 0.708721 | 3 | 0 | 3 |
| INPP5K | SLC25A19 | 0.701146 | 3 | 0 | 3 |
| INPP5K | EIF3C | 0.699085 | 3 | 0 | 3 |
| INPP5K | HIGD2A | 0.695505 | 3 | 0 | 3 |
| INPP5K | KLHDC3 | 0.695342 | 3 | 0 | 3 |
| INPP5K | DMWD | 0.689069 | 5 | 0 | 5 |
| INPP5K | GJC2 | 0.689026 | 3 | 0 | 3 |
| INPP5K | TRIM26 | 0.687428 | 4 | 0 | 4 |
| INPP5K | LSM7 | 0.68573 | 3 | 0 | 3 |
| INPP5K | ESCO1 | 0.679992 | 3 | 0 | 3 |
| INPP5K | SORBS3 | 0.679728 | 3 | 0 | 3 |
| INPP5K | ZNF836 | 0.679616 | 3 | 0 | 3 |
| INPP5K | POLR2J | 0.677259 | 3 | 0 | 3 |
For details and further investigation, click here
