| Full name: Sp7 transcription factor | Alias Symbol: osterix|OSX | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 121340 | HGNC ID: HGNC:17321 | Ensembl Gene: ENSG00000170374 | OMIM ID: 606633 |
| Drug and gene relationship at DGIdb | |||
Expression of SP7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SP7 | 121340 | 1552340_at | -0.0653 | 0.8087 | |
| GSE26886 | SP7 | 121340 | 1552340_at | -0.1594 | 0.1640 | |
| GSE45670 | SP7 | 121340 | 1552340_at | 0.1928 | 0.0093 | |
| GSE63941 | SP7 | 121340 | 1552340_at | -0.0069 | 0.9636 | |
| GSE77861 | SP7 | 121340 | 1552340_at | -0.0251 | 0.8548 | |
| GSE97050 | SP7 | 121340 | A_33_P3352664 | 0.0722 | 0.7653 | |
| TCGA | SP7 | 121340 | RNAseq | 1.0813 | 0.2498 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SP7 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SP7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SP7 | 121340 | 7 | 1 | 22 | |
| GSE20123 | SP7 | 121340 | 7 | 1 | 22 | |
| GSE43470 | SP7 | 121340 | 3 | 0 | 40 | |
| GSE46452 | SP7 | 121340 | 7 | 1 | 51 | |
| GSE47630 | SP7 | 121340 | 10 | 2 | 28 | |
| GSE54993 | SP7 | 121340 | 0 | 5 | 65 | |
| GSE54994 | SP7 | 121340 | 4 | 1 | 48 | |
| GSE60625 | SP7 | 121340 | 0 | 0 | 11 | |
| GSE74703 | SP7 | 121340 | 3 | 0 | 33 | |
| GSE74704 | SP7 | 121340 | 5 | 1 | 14 | |
| TCGA | SP7 | 121340 | 14 | 11 | 71 |
Total number of gains: 60; Total number of losses: 23; Total Number of normals: 405.
Somatic mutations of SP7:
Generating mutation plots.
Highly correlated genes for SP7:
Showing top 20/187 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SP7 | AMHR2 | 0.788121 | 3 | 0 | 3 |
| SP7 | SLC22A12 | 0.787868 | 3 | 0 | 3 |
| SP7 | MUC2 | 0.780027 | 3 | 0 | 3 |
| SP7 | TEX13A | 0.773272 | 3 | 0 | 3 |
| SP7 | SPRED3 | 0.77288 | 3 | 0 | 3 |
| SP7 | ARVCF | 0.76384 | 3 | 0 | 3 |
| SP7 | CCDC33 | 0.758912 | 3 | 0 | 3 |
| SP7 | THPO | 0.752714 | 3 | 0 | 3 |
| SP7 | GDNF | 0.751346 | 3 | 0 | 3 |
| SP7 | RNF123 | 0.746745 | 3 | 0 | 3 |
| SP7 | HTR3A | 0.744774 | 3 | 0 | 3 |
| SP7 | DNAI1 | 0.738502 | 4 | 0 | 3 |
| SP7 | LRFN4 | 0.735857 | 3 | 0 | 3 |
| SP7 | SYCE3 | 0.733309 | 3 | 0 | 3 |
| SP7 | INSL3 | 0.730063 | 3 | 0 | 3 |
| SP7 | HRCT1 | 0.729214 | 3 | 0 | 3 |
| SP7 | OSM | 0.725994 | 4 | 0 | 4 |
| SP7 | TGM7 | 0.719066 | 4 | 0 | 4 |
| SP7 | OR2H2 | 0.712049 | 4 | 0 | 4 |
| SP7 | TCTE1 | 0.709725 | 3 | 0 | 3 |
For details and further investigation, click here
