TTK

 

Full name: TTK protein kinase Alias Symbol: MPS1|MPS1L1|CT96|MPH1
Type: protein-coding gene Cytoband: 6q14.1
Entrez ID: 7272 HGNC ID: HGNC:12401 Ensembl Gene: ENSG00000112742 OMIM ID: 604092
Drug and gene relationship at DGIdb
Screen Evidence:

 

TTK involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of TTK:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TTK 7272 204822_at 1.1825 0.0263
GSE20347 TTK 7272 204822_at 1.5983 0.0000
GSE23400 TTK 7272 204822_at 1.6429 0.0000
GSE26886 TTK 7272 204822_at 1.1198 0.0239
GSE29001 TTK 7272 204822_at 1.3328 0.0018
GSE38129 TTK 7272 204822_at 1.9785 0.0000
GSE45670 TTK 7272 204822_at 1.4493 0.0000
GSE53622 TTK 7272 102872 1.7930 0.0000
GSE53624 TTK 7272 102872 1.8526 0.0000
GSE63941 TTK 7272 204822_at 3.9036 0.0000
GSE77861 TTK 7272 204822_at 1.0845 0.0346
GSE97050 TTK 7272 A_23_P259586 0.8873 0.1143
SRP007169 TTK 7272 RNAseq 1.6505 0.0003
SRP008496 TTK 7272 RNAseq 1.2034 0.0007
SRP064894 TTK 7272 RNAseq 1.4330 0.0004
SRP133303 TTK 7272 RNAseq 1.5520 0.0000
SRP159526 TTK 7272 RNAseq 0.7898 0.0036
SRP193095 TTK 7272 RNAseq 0.5902 0.0016
SRP219564 TTK 7272 RNAseq 1.0032 0.2371
TCGA TTK 7272 RNAseq 0.9561 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by TTK expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TTK:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TTK 7272 1 4 25
GSE20123 TTK 7272 1 3 26
GSE43470 TTK 7272 2 1 40
GSE46452 TTK 7272 2 11 46
GSE47630 TTK 7272 8 6 26
GSE54993 TTK 7272 3 2 65
GSE54994 TTK 7272 8 7 38
GSE60625 TTK 7272 0 1 10
GSE74703 TTK 7272 2 1 33
GSE74704 TTK 7272 0 2 18
TCGA TTK 7272 6 21 69

Total number of gains: 33; Total number of losses: 59; Total Number of normals: 396.  

 

Somatic mutations of TTK:

 

Generating mutation plots.

 

Highly correlated genes for TTK:

 

Showing top 20/1910 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TTKBUB1B0.886824909
TTKRACGAP10.8595910010
TTKANLN0.854719808
TTKCCNA20.85363912012
TTKMTFR20.853088707
TTKASPM0.85269713012
TTKKIF18B0.8481510010
TTKCDK10.84794812012
TTKDLGAP50.84486411011
TTKCCNB20.84357612011
TTKGINS10.84081612012
TTKBUB10.83930911010
TTKNEK20.83848713013
TTKUCK20.836888303
TTKUBE2T0.835709808
TTKKIF140.83419713012
TTKCENPF0.83145213012
TTKNUSAP10.82903713012
TTKKIF230.82867712012
TTKSPAG50.82796112012

For details and further investigation, click here