HEATR1

 

Full name: HEAT repeat containing 1 Alias Symbol: FLJ10359|BAP28|UTP10
Type: protein-coding gene Cytoband: 1q43
Entrez ID: 55127 HGNC ID: HGNC:25517 Ensembl Gene: ENSG00000119285 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of HEATR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HEATR1 55127 218594_at 1.2692 0.0126
GSE20347 HEATR1 55127 218595_s_at 0.6999 0.0000
GSE23400 HEATR1 55127 218595_s_at 0.7713 0.0000
GSE26886 HEATR1 55127 218595_s_at 1.1763 0.0000
GSE29001 HEATR1 55127 218595_s_at 0.8002 0.0010
GSE38129 HEATR1 55127 218595_s_at 0.9819 0.0000
GSE45670 HEATR1 55127 218595_s_at 0.7115 0.0000
GSE53622 HEATR1 55127 2100 0.8224 0.0000
GSE53624 HEATR1 55127 2100 0.7409 0.0000
GSE63941 HEATR1 55127 218595_s_at 0.9421 0.0030
GSE77861 HEATR1 55127 218595_s_at 0.7650 0.0073
GSE97050 HEATR1 55127 A_23_P103628 0.4191 0.2460
SRP007169 HEATR1 55127 RNAseq 1.9300 0.0000
SRP008496 HEATR1 55127 RNAseq 1.9934 0.0000
SRP064894 HEATR1 55127 RNAseq 0.4606 0.0704
SRP133303 HEATR1 55127 RNAseq 0.7180 0.0000
SRP159526 HEATR1 55127 RNAseq 0.4321 0.2195
SRP193095 HEATR1 55127 RNAseq 0.5576 0.0000
SRP219564 HEATR1 55127 RNAseq 0.6311 0.1497
TCGA HEATR1 55127 RNAseq 0.2521 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by HEATR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HEATR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HEATR1 55127 10 1 19
GSE20123 HEATR1 55127 11 1 18
GSE43470 HEATR1 55127 8 1 34
GSE46452 HEATR1 55127 4 2 53
GSE47630 HEATR1 55127 15 0 25
GSE54993 HEATR1 55127 0 6 64
GSE54994 HEATR1 55127 16 0 37
GSE60625 HEATR1 55127 0 0 11
GSE74703 HEATR1 55127 8 1 27
GSE74704 HEATR1 55127 5 0 15
TCGA HEATR1 55127 43 4 49

Total number of gains: 120; Total number of losses: 16; Total Number of normals: 352.  

 

Somatic mutations of HEATR1:

 

Generating mutation plots.

 

Highly correlated genes for HEATR1:

 

Showing top 20/2071 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HEATR1C1orf1310.826162909
HEATR1GORAB0.796281707
HEATR1MMS22L0.792333303
HEATR1CENPF0.78791412012
HEATR1PSME40.78460611011
HEATR1DDX550.779973707
HEATR1MTERF30.776495808
HEATR1DTL0.77256513012
HEATR1FAM89A0.771558303
HEATR1RRP150.7692613012
HEATR1URB20.76853512011
HEATR1DNAJC20.76809112011
HEATR1TMEM1380.764301707
HEATR1CAD0.76405712012
HEATR1COA60.76395707
HEATR1FUS0.762597909
HEATR1POLR1A0.761758303
HEATR1CCT6A0.761091908
HEATR1CKS1B0.75796613012
HEATR1ISG20L20.75602612011

For details and further investigation, click here