ASPM

 

Full name: abnormal spindle microtubule assembly Alias Symbol: Calmbp1|ASP|FLJ10517|FLJ10549
Type: protein-coding gene Cytoband: 1q31.3
Entrez ID: 259266 HGNC ID: HGNC:19048 Ensembl Gene: ENSG00000066279 OMIM ID: 605481
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of ASPM:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ASPM 259266 219918_s_at 1.3353 0.0770
GSE20347 ASPM 259266 219918_s_at 1.5607 0.0000
GSE23400 ASPM 259266 219918_s_at 1.9152 0.0000
GSE26886 ASPM 259266 219918_s_at 1.1298 0.0039
GSE29001 ASPM 259266 219918_s_at 1.6305 0.0016
GSE38129 ASPM 259266 219918_s_at 2.1122 0.0000
GSE45670 ASPM 259266 219918_s_at 1.4459 0.0000
GSE53622 ASPM 259266 100979 1.9890 0.0000
GSE53624 ASPM 259266 100979 2.0627 0.0000
GSE63941 ASPM 259266 219918_s_at 2.6956 0.0022
GSE77861 ASPM 259266 219918_s_at 1.1287 0.0331
GSE97050 ASPM 259266 A_23_P52017 1.1565 0.1224
SRP007169 ASPM 259266 RNAseq 2.1181 0.0001
SRP008496 ASPM 259266 RNAseq 2.2422 0.0000
SRP064894 ASPM 259266 RNAseq 1.3897 0.0001
SRP133303 ASPM 259266 RNAseq 1.4829 0.0000
SRP159526 ASPM 259266 RNAseq 1.3178 0.0034
SRP193095 ASPM 259266 RNAseq 0.7869 0.0000
SRP219564 ASPM 259266 RNAseq 1.2664 0.1625
TCGA ASPM 259266 RNAseq 1.2222 0.0000

Upregulated datasets: 16; Downregulated datasets: 0.  

 

Survival by ASPM expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ASPM:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ASPM 259266 6 1 23
GSE20123 ASPM 259266 6 1 23
GSE43470 ASPM 259266 5 1 37
GSE46452 ASPM 259266 3 1 55
GSE47630 ASPM 259266 14 0 26
GSE54993 ASPM 259266 0 6 64
GSE54994 ASPM 259266 16 0 37
GSE60625 ASPM 259266 0 0 11
GSE74703 ASPM 259266 5 1 30
GSE74704 ASPM 259266 2 1 17
TCGA ASPM 259266 41 6 49

Total number of gains: 98; Total number of losses: 18; Total Number of normals: 372.  

 

Somatic mutations of ASPM:

 

Generating mutation plots.

 

Highly correlated genes for ASPM:

 

Showing top 20/2065 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ASPMCENPF0.89416313012
ASPMNUF20.890357909
ASPMTOP2A0.88459513013
ASPMNEK20.88238913013
ASPMKIF140.88065513013
ASPMNUSAP10.85961213013
ASPMBUB10.85790211011
ASPMCCNB20.85547612012
ASPMDTL0.85434913013
ASPMTTK0.85269713012
ASPMBUB1B0.8512951009
ASPMRACGAP10.8460711011
ASPMKIF20A0.84300113013
ASPMCENPE0.83977313012
ASPMCDK10.83867512012
ASPMATAD20.83830112012
ASPMTPX20.83577813012
ASPMCEP550.8357713012
ASPMKIF18B0.83214410010
ASPMCDKN30.82473413012

For details and further investigation, click here