| Full name: pleckstrin homology, MyTH4 and FERM domain containing H1 | Alias Symbol: KIAA1200 | ||
| Type: protein-coding gene | Cytoband: 14q24.1 | ||
| Entrez ID: 57475 | HGNC ID: HGNC:17733 | Ensembl Gene: ENSG00000054690 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHH1 | 57475 | 225726_s_at | 0.0127 | 0.9928 | |
| GSE26886 | PLEKHH1 | 57475 | 225726_s_at | 0.7117 | 0.0604 | |
| GSE45670 | PLEKHH1 | 57475 | 225726_s_at | 0.3231 | 0.2104 | |
| GSE53622 | PLEKHH1 | 57475 | 150799 | -0.3925 | 0.0460 | |
| GSE53624 | PLEKHH1 | 57475 | 150799 | -0.6424 | 0.0000 | |
| GSE63941 | PLEKHH1 | 57475 | 225726_s_at | 3.1599 | 0.0000 | |
| GSE77861 | PLEKHH1 | 57475 | 225727_at | 0.1750 | 0.2149 | |
| GSE97050 | PLEKHH1 | 57475 | A_24_P134850 | 0.1530 | 0.4085 | |
| SRP007169 | PLEKHH1 | 57475 | RNAseq | 0.4279 | 0.4706 | |
| SRP064894 | PLEKHH1 | 57475 | RNAseq | -0.5194 | 0.1213 | |
| SRP133303 | PLEKHH1 | 57475 | RNAseq | -0.6725 | 0.0016 | |
| SRP159526 | PLEKHH1 | 57475 | RNAseq | -0.2450 | 0.5741 | |
| SRP193095 | PLEKHH1 | 57475 | RNAseq | -0.2248 | 0.4569 | |
| SRP219564 | PLEKHH1 | 57475 | RNAseq | 0.6520 | 0.2937 | |
| TCGA | PLEKHH1 | 57475 | RNAseq | -0.6059 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PLEKHH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHH1 | 57475 | 7 | 2 | 21 | |
| GSE20123 | PLEKHH1 | 57475 | 7 | 2 | 21 | |
| GSE43470 | PLEKHH1 | 57475 | 8 | 2 | 33 | |
| GSE46452 | PLEKHH1 | 57475 | 16 | 3 | 40 | |
| GSE47630 | PLEKHH1 | 57475 | 11 | 9 | 20 | |
| GSE54993 | PLEKHH1 | 57475 | 3 | 9 | 58 | |
| GSE54994 | PLEKHH1 | 57475 | 18 | 5 | 30 | |
| GSE60625 | PLEKHH1 | 57475 | 0 | 2 | 9 | |
| GSE74703 | PLEKHH1 | 57475 | 7 | 2 | 27 | |
| GSE74704 | PLEKHH1 | 57475 | 3 | 2 | 15 | |
| TCGA | PLEKHH1 | 57475 | 33 | 14 | 49 |
Total number of gains: 113; Total number of losses: 52; Total Number of normals: 323.
Somatic mutations of PLEKHH1:
Generating mutation plots.
Highly correlated genes for PLEKHH1:
Showing top 20/302 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHH1 | DICER1 | 0.859912 | 3 | 0 | 3 |
| PLEKHH1 | PAN2 | 0.80396 | 3 | 0 | 3 |
| PLEKHH1 | RACGAP1 | 0.79711 | 3 | 0 | 3 |
| PLEKHH1 | WDHD1 | 0.784411 | 3 | 0 | 3 |
| PLEKHH1 | RUFY3 | 0.782682 | 3 | 0 | 3 |
| PLEKHH1 | KIAA0895 | 0.780707 | 3 | 0 | 3 |
| PLEKHH1 | POLR2J | 0.775856 | 3 | 0 | 3 |
| PLEKHH1 | YWHAE | 0.770223 | 3 | 0 | 3 |
| PLEKHH1 | JAG2 | 0.769228 | 3 | 0 | 3 |
| PLEKHH1 | CD22 | 0.769191 | 3 | 0 | 3 |
| PLEKHH1 | LSM4 | 0.767302 | 3 | 0 | 3 |
| PLEKHH1 | VRK1 | 0.755754 | 3 | 0 | 3 |
| PLEKHH1 | FAM86C1 | 0.754141 | 3 | 0 | 3 |
| PLEKHH1 | AKAP8L | 0.750854 | 3 | 0 | 3 |
| PLEKHH1 | ZNF146 | 0.749741 | 3 | 0 | 3 |
| PLEKHH1 | DDOST | 0.747473 | 3 | 0 | 3 |
| PLEKHH1 | KRT8 | 0.745872 | 3 | 0 | 3 |
| PLEKHH1 | SHMT2 | 0.743444 | 3 | 0 | 3 |
| PLEKHH1 | CHD7 | 0.740526 | 4 | 0 | 4 |
| PLEKHH1 | MTPAP | 0.740419 | 3 | 0 | 3 |
For details and further investigation, click here
