RACGAP1

 

Full name: Rac GTPase activating protein 1 Alias Symbol: MgcRacGAP
Type: protein-coding gene Cytoband: 12q13.12
Entrez ID: 29127 HGNC ID: HGNC:9804 Ensembl Gene: ENSG00000161800 OMIM ID: 604980
Drug and gene relationship at DGIdb

 

Expression of RACGAP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RACGAP1 29127 222077_s_at 0.7271 0.1241
GSE20347 RACGAP1 29127 222077_s_at 0.9881 0.0000
GSE23400 RACGAP1 29127 222077_s_at 1.1382 0.0000
GSE26886 RACGAP1 29127 222077_s_at 0.8599 0.0050
GSE29001 RACGAP1 29127 222077_s_at 0.9498 0.0437
GSE38129 RACGAP1 29127 222077_s_at 1.2237 0.0000
GSE45670 RACGAP1 29127 222077_s_at 0.8851 0.0000
GSE63941 RACGAP1 29127 222077_s_at 2.3945 0.0001
GSE77861 RACGAP1 29127 222077_s_at 0.7032 0.0230
GSE97050 RACGAP1 29127 A_32_P186474 0.6038 0.1323
SRP007169 RACGAP1 29127 RNAseq 0.7690 0.0497
SRP008496 RACGAP1 29127 RNAseq 0.5863 0.0179
SRP064894 RACGAP1 29127 RNAseq 0.8565 0.0005
SRP133303 RACGAP1 29127 RNAseq 1.0216 0.0000
SRP159526 RACGAP1 29127 RNAseq 0.7110 0.0056
SRP193095 RACGAP1 29127 RNAseq 0.5335 0.0002
SRP219564 RACGAP1 29127 RNAseq 0.6386 0.2123
TCGA RACGAP1 29127 RNAseq 0.5469 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by RACGAP1 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of RACGAP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RACGAP1 29127 8 1 21
GSE20123 RACGAP1 29127 8 1 21
GSE43470 RACGAP1 29127 3 0 40
GSE46452 RACGAP1 29127 8 1 50
GSE47630 RACGAP1 29127 11 2 27
GSE54993 RACGAP1 29127 0 5 65
GSE54994 RACGAP1 29127 4 1 48
GSE60625 RACGAP1 29127 0 0 11
GSE74703 RACGAP1 29127 3 0 33
GSE74704 RACGAP1 29127 5 1 14
TCGA RACGAP1 29127 15 11 70

Total number of gains: 65; Total number of losses: 23; Total Number of normals: 400.  

 

Somatic mutations of RACGAP1:

 

Generating mutation plots.

 

Highly correlated genes for RACGAP1:

 

Showing top 20/1809 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RACGAP1MTFR20.878298505
RACGAP1TTK0.8595910010
RACGAP1DLGAP50.85681510010
RACGAP1CCNB20.84876610010
RACGAP1ASPM0.8460711011
RACGAP1ANLN0.844752707
RACGAP1NUSAP10.83456411011
RACGAP1GINS10.83396810010
RACGAP1TOP2A0.83029311011
RACGAP1KIF150.826706909
RACGAP1CENPF0.82315610010
RACGAP1KIF18B0.820164908
RACGAP1GMNN0.82007711011
RACGAP1MAD2L10.81761210010
RACGAP1DTL0.81684811011
RACGAP1CDCA20.812978707
RACGAP1KIF230.81119511011
RACGAP1CDK10.8110421009
RACGAP1NUF20.810989706
RACGAP1DBF40.80886910010

For details and further investigation, click here