| Full name: interleukin 1 receptor associated kinase 1 binding protein 1 | Alias Symbol: AIP70|SIMPL | ||
| Type: protein-coding gene | Cytoband: 6q14.1 | ||
| Entrez ID: 134728 | HGNC ID: HGNC:17368 | Ensembl Gene: ENSG00000146243 | OMIM ID: 615375 |
| Drug and gene relationship at DGIdb | |||
Expression of IRAK1BP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRAK1BP1 | 134728 | 238599_at | 0.1150 | 0.8634 | |
| GSE26886 | IRAK1BP1 | 134728 | 238599_at | 0.4591 | 0.0976 | |
| GSE45670 | IRAK1BP1 | 134728 | 238599_at | 0.0398 | 0.9131 | |
| GSE53622 | IRAK1BP1 | 134728 | 57610 | -0.5799 | 0.0001 | |
| GSE53624 | IRAK1BP1 | 134728 | 57610 | -0.1527 | 0.1591 | |
| GSE63941 | IRAK1BP1 | 134728 | 238599_at | 0.4277 | 0.6448 | |
| GSE77861 | IRAK1BP1 | 134728 | 238599_at | -0.0831 | 0.6604 | |
| GSE97050 | IRAK1BP1 | 134728 | A_32_P21474 | -0.4674 | 0.1923 | |
| SRP007169 | IRAK1BP1 | 134728 | RNAseq | -0.3906 | 0.4758 | |
| SRP008496 | IRAK1BP1 | 134728 | RNAseq | 0.3906 | 0.3627 | |
| SRP064894 | IRAK1BP1 | 134728 | RNAseq | -0.4950 | 0.0098 | |
| SRP133303 | IRAK1BP1 | 134728 | RNAseq | -0.0998 | 0.5400 | |
| SRP159526 | IRAK1BP1 | 134728 | RNAseq | 0.0334 | 0.9013 | |
| SRP193095 | IRAK1BP1 | 134728 | RNAseq | -0.2967 | 0.0142 | |
| SRP219564 | IRAK1BP1 | 134728 | RNAseq | -0.2543 | 0.5138 | |
| TCGA | IRAK1BP1 | 134728 | RNAseq | -0.3585 | 0.0105 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IRAK1BP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRAK1BP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRAK1BP1 | 134728 | 2 | 4 | 24 | |
| GSE20123 | IRAK1BP1 | 134728 | 2 | 3 | 25 | |
| GSE43470 | IRAK1BP1 | 134728 | 2 | 0 | 41 | |
| GSE46452 | IRAK1BP1 | 134728 | 3 | 11 | 45 | |
| GSE47630 | IRAK1BP1 | 134728 | 8 | 6 | 26 | |
| GSE54993 | IRAK1BP1 | 134728 | 3 | 2 | 65 | |
| GSE54994 | IRAK1BP1 | 134728 | 8 | 7 | 38 | |
| GSE60625 | IRAK1BP1 | 134728 | 0 | 1 | 10 | |
| GSE74703 | IRAK1BP1 | 134728 | 2 | 0 | 34 | |
| GSE74704 | IRAK1BP1 | 134728 | 1 | 2 | 17 | |
| TCGA | IRAK1BP1 | 134728 | 6 | 22 | 68 |
Total number of gains: 37; Total number of losses: 58; Total Number of normals: 393.
Somatic mutations of IRAK1BP1:
Generating mutation plots.
Highly correlated genes for IRAK1BP1:
Showing top 20/102 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRAK1BP1 | FAM168A | 0.779424 | 3 | 0 | 3 |
| IRAK1BP1 | MYO3B | 0.742914 | 3 | 0 | 3 |
| IRAK1BP1 | PCMTD1 | 0.740066 | 3 | 0 | 3 |
| IRAK1BP1 | CEP192 | 0.73757 | 3 | 0 | 3 |
| IRAK1BP1 | CHL1 | 0.732464 | 3 | 0 | 3 |
| IRAK1BP1 | EIF1AX | 0.728331 | 3 | 0 | 3 |
| IRAK1BP1 | TSEN2 | 0.714438 | 4 | 0 | 4 |
| IRAK1BP1 | INTS4 | 0.708707 | 3 | 0 | 3 |
| IRAK1BP1 | RSF1 | 0.706186 | 3 | 0 | 3 |
| IRAK1BP1 | TMEM30A | 0.702755 | 4 | 0 | 3 |
| IRAK1BP1 | ZNF10 | 0.696804 | 3 | 0 | 3 |
| IRAK1BP1 | CD164 | 0.696611 | 3 | 0 | 3 |
| IRAK1BP1 | LYPLAL1 | 0.695108 | 3 | 0 | 3 |
| IRAK1BP1 | MTMR2 | 0.691303 | 3 | 0 | 3 |
| IRAK1BP1 | TET1 | 0.675903 | 4 | 0 | 3 |
| IRAK1BP1 | PCDH7 | 0.673274 | 4 | 0 | 4 |
| IRAK1BP1 | MIPOL1 | 0.6694 | 4 | 0 | 3 |
| IRAK1BP1 | SLC25A21 | 0.665329 | 4 | 0 | 3 |
| IRAK1BP1 | LGALS8 | 0.664334 | 3 | 0 | 3 |
| IRAK1BP1 | USP11 | 0.662153 | 3 | 0 | 3 |
For details and further investigation, click here
