| Full name: tet methylcytosine dioxygenase 1 | Alias Symbol: LCX|KIAA1676|bA119F7.1 | ||
| Type: protein-coding gene | Cytoband: 10q21.3 | ||
| Entrez ID: 80312 | HGNC ID: HGNC:29484 | Ensembl Gene: ENSG00000138336 | OMIM ID: 607790 |
| Drug and gene relationship at DGIdb | |||
Expression of TET1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TET1 | 80312 | 228906_at | 0.9763 | 0.0638 | |
| GSE26886 | TET1 | 80312 | 228906_at | 0.5168 | 0.0934 | |
| GSE45670 | TET1 | 80312 | 228906_at | -0.0383 | 0.9165 | |
| GSE53622 | TET1 | 80312 | 10769 | -0.0976 | 0.5713 | |
| GSE53624 | TET1 | 80312 | 3266 | 0.7257 | 0.0000 | |
| GSE63941 | TET1 | 80312 | 228906_at | 0.4259 | 0.6236 | |
| GSE77861 | TET1 | 80312 | 228906_at | 0.0149 | 0.8905 | |
| GSE97050 | TET1 | 80312 | A_23_P322756 | -1.0344 | 0.0665 | |
| SRP007169 | TET1 | 80312 | RNAseq | 3.1471 | 0.0000 | |
| SRP008496 | TET1 | 80312 | RNAseq | 2.8385 | 0.0000 | |
| SRP064894 | TET1 | 80312 | RNAseq | 0.6827 | 0.0180 | |
| SRP133303 | TET1 | 80312 | RNAseq | 0.0663 | 0.7766 | |
| SRP159526 | TET1 | 80312 | RNAseq | 1.6888 | 0.0000 | |
| SRP193095 | TET1 | 80312 | RNAseq | 0.7139 | 0.0017 | |
| SRP219564 | TET1 | 80312 | RNAseq | 1.4036 | 0.0013 | |
| TCGA | TET1 | 80312 | RNAseq | 0.2874 | 0.0994 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by TET1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TET1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TET1 | 80312 | 3 | 5 | 22 | |
| GSE20123 | TET1 | 80312 | 3 | 4 | 23 | |
| GSE43470 | TET1 | 80312 | 1 | 8 | 34 | |
| GSE46452 | TET1 | 80312 | 0 | 11 | 48 | |
| GSE47630 | TET1 | 80312 | 2 | 14 | 24 | |
| GSE54993 | TET1 | 80312 | 8 | 0 | 62 | |
| GSE54994 | TET1 | 80312 | 2 | 12 | 39 | |
| GSE60625 | TET1 | 80312 | 0 | 0 | 11 | |
| GSE74703 | TET1 | 80312 | 1 | 5 | 30 | |
| GSE74704 | TET1 | 80312 | 1 | 2 | 17 | |
| TCGA | TET1 | 80312 | 10 | 22 | 64 |
Total number of gains: 31; Total number of losses: 83; Total Number of normals: 374.
Somatic mutations of TET1:
Generating mutation plots.
Highly correlated genes for TET1:
Showing top 20/314 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TET1 | CUX1 | 0.744205 | 3 | 0 | 3 |
| TET1 | TSEN15 | 0.7378 | 3 | 0 | 3 |
| TET1 | FOXK2 | 0.736904 | 3 | 0 | 3 |
| TET1 | FAM86C1 | 0.736466 | 3 | 0 | 3 |
| TET1 | PPP1R10 | 0.734083 | 3 | 0 | 3 |
| TET1 | CAMSAP2 | 0.734046 | 3 | 0 | 3 |
| TET1 | TRIM28 | 0.733517 | 3 | 0 | 3 |
| TET1 | RNPS1 | 0.732705 | 3 | 0 | 3 |
| TET1 | CEP63 | 0.730059 | 3 | 0 | 3 |
| TET1 | BANF1 | 0.728396 | 3 | 0 | 3 |
| TET1 | PLCL1 | 0.726542 | 3 | 0 | 3 |
| TET1 | ERP27 | 0.726102 | 3 | 0 | 3 |
| TET1 | POMGNT1 | 0.724726 | 3 | 0 | 3 |
| TET1 | C20orf27 | 0.723885 | 3 | 0 | 3 |
| TET1 | BCL9 | 0.718001 | 4 | 0 | 4 |
| TET1 | CEP68 | 0.712939 | 3 | 0 | 3 |
| TET1 | MAP9 | 0.710524 | 3 | 0 | 3 |
| TET1 | ZNF567 | 0.706901 | 3 | 0 | 3 |
| TET1 | DEXI | 0.704992 | 3 | 0 | 3 |
| TET1 | DNAJC13 | 0.702327 | 3 | 0 | 3 |
For details and further investigation, click here
