| Full name: tRNA splicing endonuclease subunit 2 | Alias Symbol: SEN2|SEN2L|MGC2776 | ||
| Type: protein-coding gene | Cytoband: 3p25.2 | ||
| Entrez ID: 80746 | HGNC ID: HGNC:28422 | Ensembl Gene: ENSG00000154743 | OMIM ID: 608753 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TSEN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSEN2 | 80746 | 219581_at | 0.0651 | 0.8781 | |
| GSE20347 | TSEN2 | 80746 | 219581_at | 0.0071 | 0.9784 | |
| GSE23400 | TSEN2 | 80746 | 219581_at | 0.0133 | 0.7294 | |
| GSE26886 | TSEN2 | 80746 | 219581_at | -0.3937 | 0.0351 | |
| GSE29001 | TSEN2 | 80746 | 219581_at | -0.0609 | 0.8760 | |
| GSE38129 | TSEN2 | 80746 | 219581_at | 0.0092 | 0.9575 | |
| GSE45670 | TSEN2 | 80746 | 219581_at | -0.0539 | 0.7743 | |
| GSE53622 | TSEN2 | 80746 | 81096 | -0.1460 | 0.0626 | |
| GSE53624 | TSEN2 | 80746 | 81096 | -0.0290 | 0.7547 | |
| GSE63941 | TSEN2 | 80746 | 219581_at | 0.3082 | 0.5925 | |
| GSE77861 | TSEN2 | 80746 | 219581_at | -0.0915 | 0.6587 | |
| GSE97050 | TSEN2 | 80746 | A_23_P92012 | -0.0059 | 0.9846 | |
| SRP007169 | TSEN2 | 80746 | RNAseq | -0.6788 | 0.1592 | |
| SRP064894 | TSEN2 | 80746 | RNAseq | -0.1848 | 0.1872 | |
| SRP133303 | TSEN2 | 80746 | RNAseq | -0.2347 | 0.1865 | |
| SRP159526 | TSEN2 | 80746 | RNAseq | -0.3185 | 0.2328 | |
| SRP193095 | TSEN2 | 80746 | RNAseq | -0.2489 | 0.0689 | |
| SRP219564 | TSEN2 | 80746 | RNAseq | -0.3043 | 0.4888 | |
| TCGA | TSEN2 | 80746 | RNAseq | -0.1573 | 0.0281 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TSEN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSEN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSEN2 | 80746 | 1 | 17 | 12 | |
| GSE20123 | TSEN2 | 80746 | 1 | 18 | 11 | |
| GSE43470 | TSEN2 | 80746 | 0 | 21 | 22 | |
| GSE46452 | TSEN2 | 80746 | 2 | 17 | 40 | |
| GSE47630 | TSEN2 | 80746 | 2 | 23 | 15 | |
| GSE54993 | TSEN2 | 80746 | 6 | 1 | 63 | |
| GSE54994 | TSEN2 | 80746 | 1 | 33 | 19 | |
| GSE60625 | TSEN2 | 80746 | 5 | 0 | 6 | |
| GSE74703 | TSEN2 | 80746 | 0 | 17 | 19 | |
| GSE74704 | TSEN2 | 80746 | 1 | 10 | 9 | |
| TCGA | TSEN2 | 80746 | 1 | 68 | 27 |
Total number of gains: 20; Total number of losses: 225; Total Number of normals: 243.
Somatic mutations of TSEN2:
Generating mutation plots.
Highly correlated genes for TSEN2:
Showing top 20/202 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSEN2 | CEP63 | 0.743341 | 3 | 0 | 3 |
| TSEN2 | PPP4R2 | 0.735209 | 4 | 0 | 4 |
| TSEN2 | ZSCAN29 | 0.732313 | 3 | 0 | 3 |
| TSEN2 | CRBN | 0.728558 | 3 | 0 | 3 |
| TSEN2 | CUL1 | 0.72761 | 3 | 0 | 3 |
| TSEN2 | COCH | 0.726572 | 3 | 0 | 3 |
| TSEN2 | MAP4K3 | 0.723659 | 3 | 0 | 3 |
| TSEN2 | IMPACT | 0.715456 | 3 | 0 | 3 |
| TSEN2 | IRAK1BP1 | 0.714438 | 4 | 0 | 4 |
| TSEN2 | IREB2 | 0.70968 | 3 | 0 | 3 |
| TSEN2 | NOM1 | 0.709518 | 3 | 0 | 3 |
| TSEN2 | FAM185A | 0.700878 | 3 | 0 | 3 |
| TSEN2 | MON1A | 0.695304 | 3 | 0 | 3 |
| TSEN2 | PPWD1 | 0.688679 | 3 | 0 | 3 |
| TSEN2 | TC2N | 0.682738 | 3 | 0 | 3 |
| TSEN2 | PSMG2 | 0.681492 | 4 | 0 | 3 |
| TSEN2 | PTPN11 | 0.677678 | 3 | 0 | 3 |
| TSEN2 | MRPS22 | 0.671903 | 4 | 0 | 3 |
| TSEN2 | NCBP1 | 0.670053 | 3 | 0 | 3 |
| TSEN2 | TRMT11 | 0.667024 | 4 | 0 | 3 |
For details and further investigation, click here
