INTS4

 

Full name: integrator complex subunit 4 Alias Symbol: INT4|MGC16733|MST093
Type: protein-coding gene Cytoband: 11q14.1
Entrez ID: 92105 HGNC ID: HGNC:25048 Ensembl Gene: ENSG00000149262 OMIM ID: 611348
Drug and gene relationship at DGIdb

 

Expression of INTS4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 INTS4 92105 225169_at 0.3669 0.5704
GSE26886 INTS4 92105 225169_at 0.5911 0.0012
GSE45670 INTS4 92105 225169_at 0.2994 0.0592
GSE53622 INTS4 92105 21218 0.3795 0.0000
GSE53624 INTS4 92105 22268 0.3699 0.0000
GSE63941 INTS4 92105 225169_at 0.2844 0.5652
GSE77861 INTS4 92105 225169_at -0.0389 0.8388
GSE97050 INTS4 A_21_P0013386 0.2987 0.2816
SRP007169 INTS4 92105 RNAseq 0.4560 0.2445
SRP008496 INTS4 92105 RNAseq 0.3772 0.1278
SRP064894 INTS4 92105 RNAseq 0.2667 0.1001
SRP133303 INTS4 92105 RNAseq -0.2834 0.0223
SRP159526 INTS4 92105 RNAseq -0.3572 0.0411
SRP193095 INTS4 92105 RNAseq -0.1281 0.3214
SRP219564 INTS4 92105 RNAseq 0.4847 0.2757
TCGA INTS4 92105 RNAseq 0.0805 0.1566

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by INTS4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of INTS4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 INTS4 92105 5 10 15
GSE20123 INTS4 92105 5 9 16
GSE43470 INTS4 92105 3 5 35
GSE46452 INTS4 92105 7 22 30
GSE47630 INTS4 92105 4 17 19
GSE54993 INTS4 92105 8 2 60
GSE54994 INTS4 92105 6 17 30
GSE60625 INTS4 92105 4 3 4
GSE74703 INTS4 92105 2 4 30
GSE74704 INTS4 92105 3 5 12
TCGA INTS4 92105 18 32 46

Total number of gains: 65; Total number of losses: 126; Total Number of normals: 297.  

 

Somatic mutations of INTS4:

 

Generating mutation plots.

 

Highly correlated genes for INTS4:

 

Showing top 20/328 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
INTS4ALG80.798272808
INTS4MRPS310.778864303
INTS4EIF3M0.773086303
INTS4MYO3B0.768232303
INTS4RBBP60.763133303
INTS4BIRC20.738064303
INTS4LTV10.733113303
INTS4HSD17B120.726607303
INTS4ZNF3000.721542303
INTS4ZNF1460.721471303
INTS4ZNF6070.716215303
INTS4NEU30.715796807
INTS4EIF1B0.714295303
INTS4SLC39A10.714124303
INTS4IRAK1BP10.708707303
INTS4OLA10.707028303
INTS4COA40.70646505
INTS4ALKBH60.705755303
INTS4MRPL90.705706403
INTS4PTPN20.704809403

For details and further investigation, click here