| Full name: interleukin 2 receptor subunit beta | Alias Symbol: CD122 | ||
| Type: protein-coding gene | Cytoband: 22q12.3 | ||
| Entrez ID: 3560 | HGNC ID: HGNC:6009 | Ensembl Gene: ENSG00000100385 | OMIM ID: 146710 |
| Drug and gene relationship at DGIdb | |||
IL2RB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05162 | Measles | |
| hsa05166 | HTLV-I infection |
Expression of IL2RB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL2RB | 3560 | 205291_at | 0.4447 | 0.5706 | |
| GSE20347 | IL2RB | 3560 | 205291_at | 0.0853 | 0.6368 | |
| GSE23400 | IL2RB | 3560 | 205291_at | 0.1434 | 0.0280 | |
| GSE26886 | IL2RB | 3560 | 205291_at | 0.4583 | 0.2402 | |
| GSE29001 | IL2RB | 3560 | 205291_at | 0.1528 | 0.4653 | |
| GSE38129 | IL2RB | 3560 | 205291_at | 0.1963 | 0.2442 | |
| GSE45670 | IL2RB | 3560 | 205291_at | 0.3539 | 0.1683 | |
| GSE53622 | IL2RB | 3560 | 71225 | 0.4887 | 0.0017 | |
| GSE53624 | IL2RB | 3560 | 71225 | 0.2990 | 0.0187 | |
| GSE63941 | IL2RB | 3560 | 205291_at | 0.0476 | 0.7980 | |
| GSE77861 | IL2RB | 3560 | 205291_at | -0.0713 | 0.6188 | |
| GSE97050 | IL2RB | 3560 | A_24_P203000 | 1.0097 | 0.1891 | |
| SRP007169 | IL2RB | 3560 | RNAseq | -0.0733 | 0.9133 | |
| SRP064894 | IL2RB | 3560 | RNAseq | 0.1665 | 0.4946 | |
| SRP133303 | IL2RB | 3560 | RNAseq | 0.4653 | 0.1420 | |
| SRP159526 | IL2RB | 3560 | RNAseq | -0.1076 | 0.9026 | |
| SRP193095 | IL2RB | 3560 | RNAseq | 0.2065 | 0.2521 | |
| SRP219564 | IL2RB | 3560 | RNAseq | 1.1443 | 0.0606 | |
| TCGA | IL2RB | 3560 | RNAseq | 0.4971 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL2RB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL2RB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL2RB | 3560 | 6 | 6 | 18 | |
| GSE20123 | IL2RB | 3560 | 6 | 5 | 19 | |
| GSE43470 | IL2RB | 3560 | 4 | 6 | 33 | |
| GSE46452 | IL2RB | 3560 | 31 | 1 | 27 | |
| GSE47630 | IL2RB | 3560 | 8 | 5 | 27 | |
| GSE54993 | IL2RB | 3560 | 3 | 6 | 61 | |
| GSE54994 | IL2RB | 3560 | 10 | 8 | 35 | |
| GSE60625 | IL2RB | 3560 | 5 | 0 | 6 | |
| GSE74703 | IL2RB | 3560 | 4 | 4 | 28 | |
| GSE74704 | IL2RB | 3560 | 3 | 2 | 15 | |
| TCGA | IL2RB | 3560 | 27 | 16 | 53 |
Total number of gains: 107; Total number of losses: 59; Total Number of normals: 322.
Somatic mutations of IL2RB:
Generating mutation plots.
Highly correlated genes for IL2RB:
Showing top 20/398 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL2RB | GNGT2 | 0.794732 | 3 | 0 | 3 |
| IL2RB | TIGIT | 0.793995 | 6 | 0 | 6 |
| IL2RB | IL12RB1 | 0.763222 | 6 | 0 | 5 |
| IL2RB | CD3D | 0.747715 | 11 | 0 | 11 |
| IL2RB | LCK | 0.739691 | 11 | 0 | 10 |
| IL2RB | GZMA | 0.738345 | 12 | 0 | 11 |
| IL2RB | CCR5 | 0.737482 | 9 | 0 | 7 |
| IL2RB | CYTIP | 0.732496 | 10 | 0 | 9 |
| IL2RB | JAK3 | 0.722352 | 5 | 0 | 4 |
| IL2RB | SAMD3 | 0.710299 | 4 | 0 | 4 |
| IL2RB | PTPN7 | 0.708129 | 8 | 0 | 6 |
| IL2RB | IL2RG | 0.708099 | 8 | 0 | 7 |
| IL2RB | FAM78A | 0.706611 | 4 | 0 | 4 |
| IL2RB | PCED1B | 0.705819 | 4 | 0 | 4 |
| IL2RB | CMTM7 | 0.703775 | 4 | 0 | 4 |
| IL2RB | ITGAL | 0.703067 | 10 | 0 | 9 |
| IL2RB | ACAP1 | 0.702464 | 5 | 0 | 5 |
| IL2RB | SNX20 | 0.700461 | 6 | 0 | 5 |
| IL2RB | GZMB | 0.699087 | 11 | 0 | 9 |
| IL2RB | SASH3 | 0.697911 | 11 | 0 | 9 |
For details and further investigation, click here
