| Full name: inter-alpha-trypsin inhibitor heavy chain 4 | Alias Symbol: IHRP|H4P | ||
| Type: protein-coding gene | Cytoband: 3p21.1 | ||
| Entrez ID: 3700 | HGNC ID: HGNC:6169 | Ensembl Gene: ENSG00000055955 | OMIM ID: 600564 |
| Drug and gene relationship at DGIdb | |||
Expression of ITIH4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITIH4 | 3700 | 206287_s_at | -0.1386 | 0.7941 | |
| GSE20347 | ITIH4 | 3700 | 206287_s_at | -0.0139 | 0.8802 | |
| GSE23400 | ITIH4 | 3700 | 206287_s_at | -0.1283 | 0.0023 | |
| GSE26886 | ITIH4 | 3700 | 206287_s_at | 0.3201 | 0.0126 | |
| GSE29001 | ITIH4 | 3700 | 206287_s_at | -0.0995 | 0.4259 | |
| GSE38129 | ITIH4 | 3700 | 206287_s_at | -0.2318 | 0.0476 | |
| GSE45670 | ITIH4 | 3700 | 37201_at | -0.2548 | 0.0033 | |
| GSE63941 | ITIH4 | 3700 | 206287_s_at | 0.0166 | 0.9378 | |
| GSE77861 | ITIH4 | 3700 | 206287_s_at | -0.1041 | 0.4764 | |
| GSE97050 | ITIH4 | 3700 | A_23_P109881 | -0.2050 | 0.4780 | |
| SRP064894 | ITIH4 | 3700 | RNAseq | 0.0718 | 0.8168 | |
| SRP133303 | ITIH4 | 3700 | RNAseq | -1.2013 | 0.0000 | |
| SRP159526 | ITIH4 | 3700 | RNAseq | -0.8333 | 0.0320 | |
| SRP193095 | ITIH4 | 3700 | RNAseq | 0.3540 | 0.1606 | |
| SRP219564 | ITIH4 | 3700 | RNAseq | -0.5806 | 0.0872 | |
| TCGA | ITIH4 | 3700 | RNAseq | -0.8079 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ITIH4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ITIH4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITIH4 | 3700 | 0 | 18 | 12 | |
| GSE20123 | ITIH4 | 3700 | 0 | 19 | 11 | |
| GSE43470 | ITIH4 | 3700 | 0 | 18 | 25 | |
| GSE46452 | ITIH4 | 3700 | 2 | 17 | 40 | |
| GSE47630 | ITIH4 | 3700 | 1 | 24 | 15 | |
| GSE54993 | ITIH4 | 3700 | 6 | 2 | 62 | |
| GSE54994 | ITIH4 | 3700 | 0 | 33 | 20 | |
| GSE60625 | ITIH4 | 3700 | 5 | 0 | 6 | |
| GSE74703 | ITIH4 | 3700 | 0 | 14 | 22 | |
| GSE74704 | ITIH4 | 3700 | 0 | 12 | 8 | |
| TCGA | ITIH4 | 3700 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 235; Total Number of normals: 239.
Somatic mutations of ITIH4:
Generating mutation plots.
Highly correlated genes for ITIH4:
Showing top 20/202 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITIH4 | SPPL2C | 0.705323 | 3 | 0 | 3 |
| ITIH4 | ARMC5 | 0.672596 | 3 | 0 | 3 |
| ITIH4 | FOXD2-AS1 | 0.666144 | 3 | 0 | 3 |
| ITIH4 | EXOC3L1 | 0.656612 | 3 | 0 | 3 |
| ITIH4 | CDH4 | 0.655768 | 4 | 0 | 3 |
| ITIH4 | TTC16 | 0.652924 | 4 | 0 | 4 |
| ITIH4 | FBXO44 | 0.65273 | 3 | 0 | 3 |
| ITIH4 | REXO1 | 0.649667 | 3 | 0 | 3 |
| ITIH4 | C6orf223 | 0.649171 | 3 | 0 | 3 |
| ITIH4 | GNG7 | 0.647591 | 4 | 0 | 4 |
| ITIH4 | SPATA25 | 0.646485 | 3 | 0 | 3 |
| ITIH4 | HMCN2 | 0.639035 | 3 | 0 | 3 |
| ITIH4 | SPI1 | 0.635979 | 4 | 0 | 3 |
| ITIH4 | ASB6 | 0.635563 | 3 | 0 | 3 |
| ITIH4 | NTRK1 | 0.635003 | 4 | 0 | 4 |
| ITIH4 | TNFRSF13B | 0.634697 | 3 | 0 | 3 |
| ITIH4 | TMEM51-AS1 | 0.630929 | 3 | 0 | 3 |
| ITIH4 | UPK3A | 0.627639 | 5 | 0 | 4 |
| ITIH4 | ENDOV | 0.62755 | 3 | 0 | 3 |
| ITIH4 | GATA6 | 0.626453 | 3 | 0 | 3 |
For details and further investigation, click here
