| Full name: GATA binding protein 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18q11.2 | ||
| Entrez ID: 2627 | HGNC ID: HGNC:4174 | Ensembl Gene: ENSG00000141448 | OMIM ID: 601656 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GATA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GATA6 | 2627 | 210002_at | -0.5842 | 0.5334 | |
| GSE20347 | GATA6 | 2627 | 210002_at | 0.0434 | 0.8607 | |
| GSE23400 | GATA6 | 2627 | 210002_at | 0.1228 | 0.2783 | |
| GSE26886 | GATA6 | 2627 | 229282_at | 0.1166 | 0.4404 | |
| GSE29001 | GATA6 | 2627 | 210002_at | 0.3255 | 0.4816 | |
| GSE38129 | GATA6 | 2627 | 210002_at | -0.3282 | 0.5018 | |
| GSE45670 | GATA6 | 2627 | 210002_at | -0.7999 | 0.1207 | |
| GSE53622 | GATA6 | 2627 | 125099 | -0.2247 | 0.4093 | |
| GSE53624 | GATA6 | 2627 | 125099 | 0.4364 | 0.0197 | |
| GSE63941 | GATA6 | 2627 | 210002_at | -1.1392 | 0.2272 | |
| GSE77861 | GATA6 | 2627 | 229282_at | -0.1215 | 0.3807 | |
| GSE97050 | GATA6 | 2627 | A_23_P304450 | 0.3224 | 0.2462 | |
| SRP007169 | GATA6 | 2627 | RNAseq | 4.5150 | 0.0009 | |
| SRP064894 | GATA6 | 2627 | RNAseq | 1.0858 | 0.0032 | |
| SRP133303 | GATA6 | 2627 | RNAseq | 0.5548 | 0.0618 | |
| SRP159526 | GATA6 | 2627 | RNAseq | 1.3738 | 0.0460 | |
| SRP219564 | GATA6 | 2627 | RNAseq | -0.2559 | 0.7782 | |
| TCGA | GATA6 | 2627 | RNAseq | -1.3988 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by GATA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GATA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GATA6 | 2627 | 3 | 6 | 21 | |
| GSE20123 | GATA6 | 2627 | 2 | 6 | 22 | |
| GSE43470 | GATA6 | 2627 | 2 | 1 | 40 | |
| GSE46452 | GATA6 | 2627 | 3 | 22 | 34 | |
| GSE47630 | GATA6 | 2627 | 7 | 17 | 16 | |
| GSE54993 | GATA6 | 2627 | 7 | 1 | 62 | |
| GSE54994 | GATA6 | 2627 | 3 | 12 | 38 | |
| GSE60625 | GATA6 | 2627 | 0 | 4 | 7 | |
| GSE74703 | GATA6 | 2627 | 2 | 1 | 33 | |
| GSE74704 | GATA6 | 2627 | 2 | 5 | 13 | |
| TCGA | GATA6 | 2627 | 17 | 21 | 58 |
Total number of gains: 48; Total number of losses: 96; Total Number of normals: 344.
Somatic mutations of GATA6:
Generating mutation plots.
Highly correlated genes for GATA6:
Showing top 20/501 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GATA6 | ZNF653 | 0.745619 | 3 | 0 | 3 |
| GATA6 | ZDHHC1 | 0.735351 | 3 | 0 | 3 |
| GATA6 | TNFRSF9 | 0.714147 | 3 | 0 | 3 |
| GATA6 | NANOS3 | 0.712258 | 3 | 0 | 3 |
| GATA6 | GUCA1A | 0.70818 | 3 | 0 | 3 |
| GATA6 | LILRA4 | 0.706359 | 3 | 0 | 3 |
| GATA6 | UTS2R | 0.700853 | 3 | 0 | 3 |
| GATA6 | PBXIP1 | 0.698953 | 4 | 0 | 4 |
| GATA6 | LDB3 | 0.698169 | 4 | 0 | 3 |
| GATA6 | ITIH5 | 0.69508 | 3 | 0 | 3 |
| GATA6 | RNF31 | 0.690444 | 3 | 0 | 3 |
| GATA6 | ICA1L | 0.690115 | 3 | 0 | 3 |
| GATA6 | DIAPH2 | 0.687961 | 3 | 0 | 3 |
| GATA6 | GNG7 | 0.679265 | 4 | 0 | 4 |
| GATA6 | CLU | 0.677968 | 3 | 0 | 3 |
| GATA6 | CREB3 | 0.677949 | 6 | 0 | 6 |
| GATA6 | SOX10 | 0.674929 | 3 | 0 | 3 |
| GATA6 | PNMT | 0.674429 | 3 | 0 | 3 |
| GATA6 | C7 | 0.671213 | 3 | 0 | 3 |
| GATA6 | DGKD | 0.669226 | 4 | 0 | 3 |
For details and further investigation, click here
