| Full name: signal peptide peptidase like 2C | Alias Symbol: IMP5 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 162540 | HGNC ID: HGNC:28902 | Ensembl Gene: ENSG00000185294 | OMIM ID: 608284 |
| Drug and gene relationship at DGIdb | |||
Expression of SPPL2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPPL2C | 162540 | 231253_at | -0.1053 | 0.6837 | |
| GSE26886 | SPPL2C | 162540 | 231253_at | 0.3048 | 0.0436 | |
| GSE45670 | SPPL2C | 162540 | 231253_at | -0.0036 | 0.9692 | |
| GSE53622 | SPPL2C | 162540 | 22187 | -0.4565 | 0.0001 | |
| GSE53624 | SPPL2C | 162540 | 22187 | -0.1532 | 0.0738 | |
| GSE63941 | SPPL2C | 162540 | 231253_at | 0.1887 | 0.2542 | |
| GSE77861 | SPPL2C | 162540 | 231253_at | -0.1741 | 0.1668 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPPL2C expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SPPL2C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPPL2C | 162540 | 5 | 2 | 23 | |
| GSE20123 | SPPL2C | 162540 | 5 | 2 | 23 | |
| GSE43470 | SPPL2C | 162540 | 1 | 2 | 40 | |
| GSE46452 | SPPL2C | 162540 | 32 | 0 | 27 | |
| GSE47630 | SPPL2C | 162540 | 9 | 0 | 31 | |
| GSE54993 | SPPL2C | 162540 | 3 | 4 | 63 | |
| GSE54994 | SPPL2C | 162540 | 9 | 6 | 38 | |
| GSE60625 | SPPL2C | 162540 | 4 | 0 | 7 | |
| GSE74703 | SPPL2C | 162540 | 1 | 1 | 34 | |
| GSE74704 | SPPL2C | 162540 | 4 | 1 | 15 | |
| TCGA | SPPL2C | 162540 | 26 | 7 | 63 |
Total number of gains: 99; Total number of losses: 25; Total Number of normals: 364.
Somatic mutations of SPPL2C:
Generating mutation plots.
Highly correlated genes for SPPL2C:
Showing top 20/88 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPPL2C | HOXD12 | 0.740275 | 3 | 0 | 3 |
| SPPL2C | ITIH4 | 0.705323 | 3 | 0 | 3 |
| SPPL2C | HMCN2 | 0.6948 | 4 | 0 | 4 |
| SPPL2C | ASB11 | 0.689926 | 3 | 0 | 3 |
| SPPL2C | EFCAB13 | 0.683021 | 3 | 0 | 3 |
| SPPL2C | FOXP3 | 0.664741 | 3 | 0 | 3 |
| SPPL2C | CRYGC | 0.660855 | 4 | 0 | 4 |
| SPPL2C | FATE1 | 0.660392 | 3 | 0 | 3 |
| SPPL2C | POU2F2 | 0.645562 | 3 | 0 | 3 |
| SPPL2C | FAM53A | 0.644686 | 3 | 0 | 3 |
| SPPL2C | FOXB1 | 0.643149 | 4 | 0 | 3 |
| SPPL2C | GATA4 | 0.64151 | 3 | 0 | 3 |
| SPPL2C | SPI1 | 0.640162 | 4 | 0 | 4 |
| SPPL2C | INSL3 | 0.631394 | 3 | 0 | 3 |
| SPPL2C | ITIH3 | 0.631001 | 3 | 0 | 3 |
| SPPL2C | NPR1 | 0.62569 | 4 | 0 | 3 |
| SPPL2C | SEC14L3 | 0.617787 | 4 | 0 | 4 |
| SPPL2C | DAO | 0.615187 | 3 | 0 | 3 |
| SPPL2C | OTOR | 0.610806 | 3 | 0 | 3 |
| SPPL2C | GRID2 | 0.607699 | 4 | 0 | 3 |
For details and further investigation, click here
