| Full name: chromosome 6 open reading frame 223 | Alias Symbol: MGC45491 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 221416 | HGNC ID: HGNC:28692 | Ensembl Gene: ENSG00000181577 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of C6orf223:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C6orf223 | 221416 | 239137_x_at | -0.0931 | 0.7107 | |
| GSE26886 | C6orf223 | 221416 | 239137_x_at | 0.2186 | 0.0639 | |
| GSE45670 | C6orf223 | 221416 | 239137_x_at | -0.0929 | 0.3573 | |
| GSE53622 | C6orf223 | 221416 | 148163 | 0.6960 | 0.0002 | |
| GSE53624 | C6orf223 | 221416 | 148163 | 0.9205 | 0.0000 | |
| GSE63941 | C6orf223 | 221416 | 239137_x_at | 0.6013 | 0.0633 | |
| GSE77861 | C6orf223 | 221416 | 239137_x_at | -0.0875 | 0.4543 | |
| SRP133303 | C6orf223 | 221416 | RNAseq | 1.7386 | 0.0023 | |
| SRP159526 | C6orf223 | 221416 | RNAseq | 2.9901 | 0.0000 | |
| SRP193095 | C6orf223 | 221416 | RNAseq | 0.3895 | 0.1008 | |
| TCGA | C6orf223 | 221416 | RNAseq | 1.8477 | 0.0002 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by C6orf223 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C6orf223:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C6orf223 | 221416 | 7 | 0 | 23 | |
| GSE20123 | C6orf223 | 221416 | 8 | 0 | 22 | |
| GSE43470 | C6orf223 | 221416 | 6 | 0 | 37 | |
| GSE46452 | C6orf223 | 221416 | 3 | 9 | 47 | |
| GSE47630 | C6orf223 | 221416 | 8 | 4 | 28 | |
| GSE54993 | C6orf223 | 221416 | 3 | 2 | 65 | |
| GSE54994 | C6orf223 | 221416 | 10 | 4 | 39 | |
| GSE60625 | C6orf223 | 221416 | 0 | 1 | 10 | |
| GSE74703 | C6orf223 | 221416 | 6 | 0 | 30 | |
| GSE74704 | C6orf223 | 221416 | 3 | 0 | 17 | |
| TCGA | C6orf223 | 221416 | 21 | 12 | 63 |
Total number of gains: 75; Total number of losses: 32; Total Number of normals: 381.
Somatic mutations of C6orf223:
Generating mutation plots.
Highly correlated genes for C6orf223:
Showing top 20/109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C6orf223 | CRYBB1 | 0.725032 | 3 | 0 | 3 |
| C6orf223 | RBAKDN | 0.72061 | 3 | 0 | 3 |
| C6orf223 | USHBP1 | 0.714167 | 3 | 0 | 3 |
| C6orf223 | PCIF1 | 0.709755 | 3 | 0 | 3 |
| C6orf223 | NOTCH4 | 0.70533 | 3 | 0 | 3 |
| C6orf223 | AMZ1 | 0.702934 | 3 | 0 | 3 |
| C6orf223 | ANKRD2 | 0.677567 | 3 | 0 | 3 |
| C6orf223 | THRSP | 0.670404 | 4 | 0 | 3 |
| C6orf223 | SLC6A9 | 0.66892 | 3 | 0 | 3 |
| C6orf223 | GTPBP10 | 0.653982 | 3 | 0 | 3 |
| C6orf223 | UCP1 | 0.651974 | 3 | 0 | 3 |
| C6orf223 | ITIH4 | 0.649171 | 3 | 0 | 3 |
| C6orf223 | LINC00313 | 0.64748 | 3 | 0 | 3 |
| C6orf223 | PANX2 | 0.644529 | 4 | 0 | 3 |
| C6orf223 | CHIA | 0.641496 | 3 | 0 | 3 |
| C6orf223 | GGT5 | 0.639936 | 3 | 0 | 3 |
| C6orf223 | LMAN1L | 0.635939 | 3 | 0 | 3 |
| C6orf223 | RNF31 | 0.635667 | 3 | 0 | 3 |
| C6orf223 | GP9 | 0.632147 | 3 | 0 | 3 |
| C6orf223 | HPCA | 0.628817 | 4 | 0 | 3 |
For details and further investigation, click here
