| Full name: inositol-trisphosphate 3-kinase B | Alias Symbol: IP3KB|IP3-3KB | ||
| Type: protein-coding gene | Cytoband: 1q42.12 | ||
| Entrez ID: 3707 | HGNC ID: HGNC:6179 | Ensembl Gene: ENSG00000143772 | OMIM ID: 147522 |
| Drug and gene relationship at DGIdb | |||
ITPKB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of ITPKB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITPKB | 3707 | 203723_at | -0.2018 | 0.8124 | |
| GSE20347 | ITPKB | 3707 | 203723_at | 0.3872 | 0.0324 | |
| GSE23400 | ITPKB | 3707 | 203723_at | -0.1941 | 0.0917 | |
| GSE26886 | ITPKB | 3707 | 203723_at | 0.5406 | 0.0308 | |
| GSE29001 | ITPKB | 3707 | 203723_at | 0.4448 | 0.0872 | |
| GSE38129 | ITPKB | 3707 | 203723_at | -0.2098 | 0.4839 | |
| GSE45670 | ITPKB | 3707 | 203723_at | -0.2036 | 0.4599 | |
| GSE53622 | ITPKB | 3707 | 30959 | -0.2935 | 0.0171 | |
| GSE53624 | ITPKB | 3707 | 30959 | 0.1004 | 0.2660 | |
| GSE63941 | ITPKB | 3707 | 203723_at | 0.4184 | 0.4823 | |
| GSE77861 | ITPKB | 3707 | 203723_at | 1.1440 | 0.0011 | |
| GSE97050 | ITPKB | 3707 | A_23_P372255 | -0.7749 | 0.1577 | |
| SRP007169 | ITPKB | 3707 | RNAseq | 1.0427 | 0.0229 | |
| SRP008496 | ITPKB | 3707 | RNAseq | 1.5018 | 0.0000 | |
| SRP064894 | ITPKB | 3707 | RNAseq | 0.1550 | 0.5578 | |
| SRP133303 | ITPKB | 3707 | RNAseq | -0.2071 | 0.4881 | |
| SRP159526 | ITPKB | 3707 | RNAseq | 0.6213 | 0.0083 | |
| SRP193095 | ITPKB | 3707 | RNAseq | 0.5745 | 0.0000 | |
| SRP219564 | ITPKB | 3707 | RNAseq | -0.5160 | 0.4044 | |
| TCGA | ITPKB | 3707 | RNAseq | -0.1157 | 0.1301 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ITPKB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITPKB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITPKB | 3707 | 11 | 0 | 19 | |
| GSE20123 | ITPKB | 3707 | 11 | 0 | 19 | |
| GSE43470 | ITPKB | 3707 | 7 | 1 | 35 | |
| GSE46452 | ITPKB | 3707 | 3 | 1 | 55 | |
| GSE47630 | ITPKB | 3707 | 15 | 0 | 25 | |
| GSE54993 | ITPKB | 3707 | 0 | 6 | 64 | |
| GSE54994 | ITPKB | 3707 | 16 | 0 | 37 | |
| GSE60625 | ITPKB | 3707 | 0 | 0 | 11 | |
| GSE74703 | ITPKB | 3707 | 7 | 1 | 28 | |
| GSE74704 | ITPKB | 3707 | 5 | 0 | 15 | |
| TCGA | ITPKB | 3707 | 46 | 3 | 47 |
Total number of gains: 121; Total number of losses: 12; Total Number of normals: 355.
Somatic mutations of ITPKB:
Generating mutation plots.
Highly correlated genes for ITPKB:
Showing top 20/917 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITPKB | IQUB | 0.775073 | 3 | 0 | 3 |
| ITPKB | ANTXR2 | 0.767643 | 4 | 0 | 4 |
| ITPKB | TLN1 | 0.765604 | 5 | 0 | 5 |
| ITPKB | FXYD1 | 0.755905 | 4 | 0 | 4 |
| ITPKB | PLIN4 | 0.744232 | 3 | 0 | 3 |
| ITPKB | PDK3 | 0.74044 | 3 | 0 | 3 |
| ITPKB | RNF150 | 0.736043 | 3 | 0 | 3 |
| ITPKB | PPP3CB | 0.734496 | 5 | 0 | 5 |
| ITPKB | TOR1AIP1 | 0.730049 | 5 | 0 | 4 |
| ITPKB | TCEAL2 | 0.719707 | 5 | 0 | 5 |
| ITPKB | SUPT7L | 0.716507 | 3 | 0 | 3 |
| ITPKB | ARHGAP6 | 0.716213 | 5 | 0 | 5 |
| ITPKB | SGCA | 0.715321 | 6 | 0 | 5 |
| ITPKB | SLC35F1 | 0.713331 | 3 | 0 | 3 |
| ITPKB | SMTN | 0.713174 | 6 | 0 | 6 |
| ITPKB | TMOD1 | 0.711082 | 5 | 0 | 4 |
| ITPKB | RASSF3 | 0.710897 | 3 | 0 | 3 |
| ITPKB | FAM13B | 0.710325 | 5 | 0 | 5 |
| ITPKB | THRA | 0.709968 | 3 | 0 | 3 |
| ITPKB | SLC39A13 | 0.70983 | 3 | 0 | 3 |
For details and further investigation, click here
