Full name: protein phosphatase 3 catalytic subunit beta	Alias Symbol: CALNA2|CNA2|PP2Bbeta
Type: protein-coding gene	Cytoband: 10q22.2
Entrez ID: 5532	HGNC ID: HGNC:9315	Ensembl Gene: ENSG00000107758	OMIM ID: 114106
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 61/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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PPP3CB involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04020	Calcium signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04114	Oocyte meiosis	View
hsa04310	Wnt signaling pathway	View
hsa04360	Axon guidance	View
hsa04370	VEGF signaling pathway	View
hsa04380	Osteoclast differentiation	View
hsa04650	Natural killer cell mediated cytotoxicity	View
hsa04660	T cell receptor signaling pathway	View
hsa04662	B cell receptor signaling pathway	View
hsa04720	Long-term potentiation	View
hsa04724	Glutamatergic synapse	View
hsa04728	Dopaminergic synapse	View
hsa04921	Oxytocin signaling pathway	View
hsa04922	Glucagon signaling pathway	View
hsa04924	Renin secretion	View
hsa05010	Alzheimer's disease	View
hsa05014	Amyotrophic lateral sclerosis (ALS)	View
hsa05031	Amphetamine addiction	View
hsa05152	Tuberculosis	View
hsa05166	HTLV-I infection	View

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Expression of PPP3CB:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	PPP3CB	5532	202432_at	-0.7708	0.1575	Show
GSE20347	PPP3CB	5532	202432_at	-0.3554	0.0153	Show
GSE23400	PPP3CB	5532	202432_at	-0.1916	0.0743	Show
GSE26886	PPP3CB	5532	202432_at	0.1101	0.6371	Show
GSE29001	PPP3CB	5532	202432_at	-0.1416	0.5589	Show
GSE38129	PPP3CB	5532	202432_at	-0.6584	0.0011	Show
GSE45670	PPP3CB	5532	202432_at	-0.7029	0.0001	Show
GSE53622	PPP3CB	5532	35713	-0.4292	0.0000	Show
GSE53624	PPP3CB	5532	35713	-0.2694	0.0006	Show
GSE63941	PPP3CB	5532	202432_at	-1.8501	0.0026	Show
GSE77861	PPP3CB	5532	202432_at	-0.0964	0.7212	Show
GSE97050	PPP3CB	5532	A_24_P98524	-0.3539	0.3349	Show
SRP007169	PPP3CB	5532	RNAseq	0.6551	0.1639	Show
SRP008496	PPP3CB	5532	RNAseq	1.1735	0.0010	Show
SRP064894	PPP3CB	5532	RNAseq	-0.1967	0.1729	Show
SRP133303	PPP3CB	5532	RNAseq	0.0468	0.7383	Show
SRP159526	PPP3CB	5532	RNAseq	-0.4026	0.1259	Show
SRP193095	PPP3CB	5532	RNAseq	-0.2093	0.0109	Show
SRP219564	PPP3CB	5532	RNAseq	-0.4519	0.3553	Show
TCGA	PPP3CB	5532	RNAseq	-0.1595	0.0007	Show

Upregulated datasets: 1; Downregulated datasets: 1.  Download Data

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Survival by PPP3CB expression:

 

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Copy number change of PPP3CB:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	PPP3CB	5532	3	4	23	Show
GSE20123	PPP3CB	5532	3	3	24	Show
GSE43470	PPP3CB	5532	2	8	33	Show
GSE46452	PPP3CB	5532	0	11	48	Show
GSE47630	PPP3CB	5532	2	14	24	Show
GSE54993	PPP3CB	5532	7	0	63	Show
GSE54994	PPP3CB	5532	2	10	41	Show
GSE60625	PPP3CB	5532	0	0	11	Show
GSE74703	PPP3CB	5532	2	5	29	Show
GSE74704	PPP3CB	5532	1	1	18	Show
TCGA	PPP3CB	5532	11	23	62	Show

Total number of gains: 33; Total number of losses: 79; Total Number of normals: 376.  Download Data

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Somatic mutations of PPP3CB:

 

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Highly correlated genes for PPP3CB:

 

Showing top 20/1192 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
PPP3CB	UBXN10	0.825928	3	0	3
PPP3CB	FIBIN	0.801883	4	0	4
PPP3CB	INTU	0.775168	3	0	3
PPP3CB	EIF4E3	0.774208	4	0	4
PPP3CB	HABP4	0.771674	6	0	6
PPP3CB	KLHDC8B	0.766971	3	0	3
PPP3CB	BCAS2	0.764051	4	0	3
PPP3CB	CNTLN	0.762597	3	0	3
PPP3CB	MIR100HG	0.761994	4	0	4
PPP3CB	NHSL2	0.760579	3	0	3
PPP3CB	INMT	0.757448	5	0	5
PPP3CB	MYOCD	0.754552	5	0	5
PPP3CB	BNIP2	0.753591	3	0	3
PPP3CB	SLIT2	0.752987	7	0	7
PPP3CB	MCAM	0.751246	6	0	6
PPP3CB	CACNA1C	0.7506	5	0	5
PPP3CB	PLEKHB1	0.749485	5	0	5
PPP3CB	NLGN4Y	0.749265	3	0	3
PPP3CB	C1QTNF7	0.747747	5	0	5
PPP3CB	FGL2	0.746297	10	0	10

For details and further investigation, click here