| Full name: involucrin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 3713 | HGNC ID: HGNC:6187 | Ensembl Gene: ENSG00000163207 | OMIM ID: 147360 |
| Drug and gene relationship at DGIdb | |||
Expression of IVL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IVL | 3713 | 214599_at | -2.2852 | 0.1584 | |
| GSE20347 | IVL | 3713 | 214599_at | -2.5475 | 0.0000 | |
| GSE23400 | IVL | 3713 | 214599_at | -1.4257 | 0.0000 | |
| GSE26886 | IVL | 3713 | 214599_at | -3.4761 | 0.0001 | |
| GSE29001 | IVL | 3713 | 214599_at | -2.2138 | 0.0016 | |
| GSE38129 | IVL | 3713 | 214599_at | -1.6817 | 0.0030 | |
| GSE45670 | IVL | 3713 | 214599_at | -0.5142 | 0.2200 | |
| GSE53622 | IVL | 3713 | 60400 | -1.3533 | 0.0000 | |
| GSE53624 | IVL | 3713 | 60400 | -1.6800 | 0.0000 | |
| GSE63941 | IVL | 3713 | 214599_at | 0.5596 | 0.4350 | |
| GSE77861 | IVL | 3713 | 214599_at | -0.8265 | 0.1675 | |
| GSE97050 | IVL | 3713 | A_23_P353524 | -0.5319 | 0.2000 | |
| SRP007169 | IVL | 3713 | RNAseq | -4.2850 | 0.0000 | |
| SRP008496 | IVL | 3713 | RNAseq | -2.4326 | 0.0076 | |
| SRP064894 | IVL | 3713 | RNAseq | -3.6258 | 0.0000 | |
| SRP133303 | IVL | 3713 | RNAseq | -3.4188 | 0.0000 | |
| SRP159526 | IVL | 3713 | RNAseq | -3.6498 | 0.0005 | |
| SRP219564 | IVL | 3713 | RNAseq | -2.6336 | 0.0535 | |
| TCGA | IVL | 3713 | RNAseq | 0.8745 | 0.0388 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by IVL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IVL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IVL | 3713 | 15 | 0 | 15 | |
| GSE20123 | IVL | 3713 | 15 | 0 | 15 | |
| GSE43470 | IVL | 3713 | 6 | 2 | 35 | |
| GSE46452 | IVL | 3713 | 3 | 1 | 55 | |
| GSE47630 | IVL | 3713 | 15 | 0 | 25 | |
| GSE54993 | IVL | 3713 | 0 | 4 | 66 | |
| GSE54994 | IVL | 3713 | 15 | 0 | 38 | |
| GSE60625 | IVL | 3713 | 0 | 0 | 11 | |
| GSE74703 | IVL | 3713 | 6 | 1 | 29 | |
| GSE74704 | IVL | 3713 | 7 | 0 | 13 | |
| TCGA | IVL | 3713 | 39 | 2 | 55 |
Total number of gains: 121; Total number of losses: 10; Total Number of normals: 357.
Somatic mutations of IVL:
Generating mutation plots.
Highly correlated genes for IVL:
Showing top 20/1174 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IVL | RNF222 | 0.892135 | 3 | 0 | 3 |
| IVL | HAMP | 0.836616 | 3 | 0 | 3 |
| IVL | C3orf20 | 0.829463 | 3 | 0 | 3 |
| IVL | VSIG10L | 0.79784 | 7 | 0 | 7 |
| IVL | SBSN | 0.797465 | 8 | 0 | 7 |
| IVL | CRCT1 | 0.79616 | 12 | 0 | 12 |
| IVL | SULT2B1 | 0.793888 | 10 | 0 | 10 |
| IVL | CNFN | 0.792299 | 8 | 0 | 8 |
| IVL | TGM1 | 0.788821 | 12 | 0 | 11 |
| IVL | NCCRP1 | 0.784686 | 4 | 0 | 4 |
| IVL | ANKRD24 | 0.783527 | 3 | 0 | 3 |
| IVL | CYSRT1 | 0.783453 | 6 | 0 | 5 |
| IVL | SPRR2E | 0.78103 | 4 | 0 | 4 |
| IVL | KPRP | 0.774303 | 4 | 0 | 4 |
| IVL | FAM163B | 0.77364 | 3 | 0 | 3 |
| IVL | SPRR2F | 0.7719 | 4 | 0 | 4 |
| IVL | LYNX1 | 0.769678 | 8 | 0 | 8 |
| IVL | C10orf99 | 0.768138 | 7 | 0 | 7 |
| IVL | RHCG | 0.768002 | 12 | 0 | 11 |
| IVL | ZNF750 | 0.763536 | 11 | 0 | 11 |
For details and further investigation, click here
