| Full name: small proline rich protein 2E | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 6704 | HGNC ID: HGNC:11265 | Ensembl Gene: ENSG00000203785 | OMIM ID: 617588 |
| Drug and gene relationship at DGIdb | |||
Expression of SPRR2E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | SPRR2E | 6704 | 19153 | -1.8482 | 0.0000 | |
| GSE53624 | SPRR2E | 6704 | 19153 | -2.4618 | 0.0000 | |
| GSE97050 | SPRR2E | 6704 | A_33_P3325704 | -0.0672 | 0.8877 | |
| SRP007169 | SPRR2E | 6704 | RNAseq | -5.7915 | 0.0000 | |
| SRP008496 | SPRR2E | 6704 | RNAseq | -4.8773 | 0.0000 | |
| SRP064894 | SPRR2E | 6704 | RNAseq | -3.0687 | 0.0000 | |
| SRP133303 | SPRR2E | 6704 | RNAseq | -2.1220 | 0.0050 | |
| SRP159526 | SPRR2E | 6704 | RNAseq | -2.9454 | 0.0086 | |
| SRP219564 | SPRR2E | 6704 | RNAseq | -5.7890 | 0.0001 | |
| TCGA | SPRR2E | 6704 | RNAseq | 0.9716 | 0.0543 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by SPRR2E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPRR2E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPRR2E | 6704 | 15 | 0 | 15 | |
| GSE20123 | SPRR2E | 6704 | 15 | 0 | 15 | |
| GSE43470 | SPRR2E | 6704 | 6 | 2 | 35 | |
| GSE46452 | SPRR2E | 6704 | 3 | 1 | 55 | |
| GSE47630 | SPRR2E | 6704 | 15 | 0 | 25 | |
| GSE54993 | SPRR2E | 6704 | 0 | 4 | 66 | |
| GSE54994 | SPRR2E | 6704 | 16 | 0 | 37 | |
| GSE60625 | SPRR2E | 6704 | 0 | 0 | 11 | |
| GSE74703 | SPRR2E | 6704 | 6 | 1 | 29 | |
| GSE74704 | SPRR2E | 6704 | 7 | 0 | 13 | |
| TCGA | SPRR2E | 6704 | 39 | 2 | 55 |
Total number of gains: 122; Total number of losses: 10; Total Number of normals: 356.
Somatic mutations of SPRR2E:
Generating mutation plots.
Highly correlated genes for SPRR2E:
Showing top 20/347 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPRR2E | SPRR2F | 0.975385 | 4 | 0 | 4 |
| SPRR2E | SPRR2D | 0.973226 | 4 | 0 | 4 |
| SPRR2E | SPRR2A | 0.961542 | 4 | 0 | 4 |
| SPRR2E | GPR45 | 0.930331 | 3 | 0 | 3 |
| SPRR2E | SPRR1B | 0.893461 | 4 | 0 | 4 |
| SPRR2E | CNFN | 0.885022 | 4 | 0 | 4 |
| SPRR2E | SPRR2B | 0.883592 | 4 | 0 | 4 |
| SPRR2E | SBSN | 0.868835 | 4 | 0 | 4 |
| SPRR2E | SPRR1A | 0.865742 | 4 | 0 | 4 |
| SPRR2E | IL36A | 0.857787 | 3 | 0 | 3 |
| SPRR2E | C19orf57 | 0.842202 | 3 | 0 | 3 |
| SPRR2E | TMPRSS11E | 0.842034 | 3 | 0 | 3 |
| SPRR2E | PGLYRP3 | 0.831027 | 3 | 0 | 3 |
| SPRR2E | CRCT1 | 0.82772 | 4 | 0 | 4 |
| SPRR2E | P2RX3 | 0.826997 | 3 | 0 | 3 |
| SPRR2E | VSIG10L | 0.824317 | 3 | 0 | 3 |
| SPRR2E | CEACAM3 | 0.823766 | 3 | 0 | 3 |
| SPRR2E | TGM1 | 0.822026 | 4 | 0 | 4 |
| SPRR2E | S100A9 | 0.818583 | 4 | 0 | 4 |
| SPRR2E | CEACAM5 | 0.815485 | 3 | 0 | 3 |
For details and further investigation, click here
