| Full name: transglutaminase 1 | Alias Symbol: TGASE|TGK|LI|LI1 | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 7051 | HGNC ID: HGNC:11777 | Ensembl Gene: ENSG00000092295 | OMIM ID: 190195 |
| Drug and gene relationship at DGIdb | |||
Expression of TGM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TGM1 | 7051 | 206008_at | -2.3364 | 0.2968 | |
| GSE20347 | TGM1 | 7051 | 206008_at | -3.3096 | 0.0000 | |
| GSE23400 | TGM1 | 7051 | 206008_at | -2.6048 | 0.0000 | |
| GSE26886 | TGM1 | 7051 | 206008_at | -5.1421 | 0.0000 | |
| GSE29001 | TGM1 | 7051 | 206008_at | -3.1097 | 0.0000 | |
| GSE38129 | TGM1 | 7051 | 206008_at | -2.4248 | 0.0000 | |
| GSE45670 | TGM1 | 7051 | 206008_at | -0.3250 | 0.4598 | |
| GSE53622 | TGM1 | 7051 | 55459 | -2.7691 | 0.0000 | |
| GSE53624 | TGM1 | 7051 | 55459 | -3.5370 | 0.0000 | |
| GSE63941 | TGM1 | 7051 | 206008_at | 0.6642 | 0.4383 | |
| GSE77861 | TGM1 | 7051 | 206008_at | -1.9533 | 0.0072 | |
| GSE97050 | TGM1 | 7051 | A_23_P65618 | -0.3513 | 0.5846 | |
| SRP007169 | TGM1 | 7051 | RNAseq | -4.6669 | 0.0000 | |
| SRP008496 | TGM1 | 7051 | RNAseq | -4.8749 | 0.0000 | |
| SRP064894 | TGM1 | 7051 | RNAseq | -3.1231 | 0.0000 | |
| SRP133303 | TGM1 | 7051 | RNAseq | -3.2691 | 0.0000 | |
| SRP159526 | TGM1 | 7051 | RNAseq | -4.4236 | 0.0000 | |
| SRP219564 | TGM1 | 7051 | RNAseq | -4.2967 | 0.0005 | |
| TCGA | TGM1 | 7051 | RNAseq | 0.7133 | 0.0215 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by TGM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TGM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TGM1 | 7051 | 8 | 3 | 19 | |
| GSE20123 | TGM1 | 7051 | 8 | 3 | 19 | |
| GSE43470 | TGM1 | 7051 | 8 | 2 | 33 | |
| GSE46452 | TGM1 | 7051 | 16 | 2 | 41 | |
| GSE47630 | TGM1 | 7051 | 11 | 10 | 19 | |
| GSE54993 | TGM1 | 7051 | 3 | 11 | 56 | |
| GSE54994 | TGM1 | 7051 | 18 | 5 | 30 | |
| GSE60625 | TGM1 | 7051 | 0 | 2 | 9 | |
| GSE74703 | TGM1 | 7051 | 7 | 2 | 27 | |
| GSE74704 | TGM1 | 7051 | 3 | 2 | 15 | |
| TCGA | TGM1 | 7051 | 27 | 12 | 57 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of TGM1:
Generating mutation plots.
Highly correlated genes for TGM1:
Showing top 20/1670 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TGM1 | CYSRT1 | 0.912787 | 6 | 0 | 6 |
| TGM1 | CLIC3 | 0.904107 | 10 | 0 | 10 |
| TGM1 | CNFN | 0.892052 | 8 | 0 | 8 |
| TGM1 | PPL | 0.881599 | 12 | 0 | 12 |
| TGM1 | RHCG | 0.880213 | 12 | 0 | 12 |
| TGM1 | SERPINB1 | 0.878473 | 12 | 0 | 12 |
| TGM1 | TMEM40 | 0.877395 | 12 | 0 | 12 |
| TGM1 | SULT2B1 | 0.874741 | 10 | 0 | 10 |
| TGM1 | TMPRSS11E | 0.872154 | 11 | 0 | 11 |
| TGM1 | CRCT1 | 0.870407 | 12 | 0 | 12 |
| TGM1 | ENDOU | 0.867347 | 11 | 0 | 11 |
| TGM1 | ZNF185 | 0.865155 | 12 | 0 | 12 |
| TGM1 | EVPL | 0.862534 | 12 | 0 | 12 |
| TGM1 | PTK6 | 0.861956 | 11 | 0 | 11 |
| TGM1 | KLK13 | 0.860983 | 12 | 0 | 12 |
| TGM1 | SCEL | 0.859789 | 12 | 0 | 12 |
| TGM1 | SBSN | 0.85566 | 8 | 0 | 8 |
| TGM1 | CSTB | 0.854976 | 12 | 0 | 12 |
| TGM1 | CWH43 | 0.852288 | 10 | 0 | 10 |
| TGM1 | GDPD3 | 0.848766 | 12 | 0 | 12 |
For details and further investigation, click here
