| Full name: C-X-C motif chemokine receptor 2 | Alias Symbol: CMKAR2|CD182 | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 3579 | HGNC ID: HGNC:6027 | Ensembl Gene: ENSG00000180871 | OMIM ID: 146928 |
| Drug and gene relationship at DGIdb | |||
CXCR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway | |
| hsa04072 | Phospholipase D signaling pathway | |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
Expression of CXCR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CXCR2 | 3579 | 207008_at | -2.8641 | 0.0624 | |
| GSE20347 | CXCR2 | 3579 | 207008_at | -4.0888 | 0.0000 | |
| GSE23400 | CXCR2 | 3579 | 207008_at | -1.4937 | 0.0000 | |
| GSE26886 | CXCR2 | 3579 | 207008_at | -5.0088 | 0.0000 | |
| GSE29001 | CXCR2 | 3579 | 207008_at | -3.7308 | 0.0000 | |
| GSE38129 | CXCR2 | 3579 | 207008_at | -3.3519 | 0.0000 | |
| GSE45670 | CXCR2 | 3579 | 207008_at | -1.0102 | 0.1495 | |
| GSE53622 | CXCR2 | 3579 | 60173 | -1.9374 | 0.0000 | |
| GSE53624 | CXCR2 | 3579 | 60173 | -2.8733 | 0.0000 | |
| GSE63941 | CXCR2 | 3579 | 207008_at | 0.2610 | 0.6345 | |
| GSE77861 | CXCR2 | 3579 | 207008_at | -3.1473 | 0.0002 | |
| GSE97050 | CXCR2 | 3579 | A_33_P3214550 | -0.7121 | 0.2157 | |
| SRP007169 | CXCR2 | 3579 | RNAseq | -5.9496 | 0.0000 | |
| SRP008496 | CXCR2 | 3579 | RNAseq | -5.7221 | 0.0000 | |
| SRP064894 | CXCR2 | 3579 | RNAseq | -3.0656 | 0.0000 | |
| SRP133303 | CXCR2 | 3579 | RNAseq | -2.7649 | 0.0000 | |
| SRP159526 | CXCR2 | 3579 | RNAseq | -3.4821 | 0.0000 | |
| SRP193095 | CXCR2 | 3579 | RNAseq | -1.5769 | 0.0000 | |
| SRP219564 | CXCR2 | 3579 | RNAseq | -3.9021 | 0.0000 | |
| TCGA | CXCR2 | 3579 | RNAseq | -0.1592 | 0.6584 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by CXCR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CXCR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CXCR2 | 3579 | 1 | 13 | 16 | |
| GSE20123 | CXCR2 | 3579 | 1 | 13 | 16 | |
| GSE43470 | CXCR2 | 3579 | 1 | 7 | 35 | |
| GSE46452 | CXCR2 | 3579 | 0 | 5 | 54 | |
| GSE47630 | CXCR2 | 3579 | 4 | 5 | 31 | |
| GSE54993 | CXCR2 | 3579 | 1 | 2 | 67 | |
| GSE54994 | CXCR2 | 3579 | 8 | 10 | 35 | |
| GSE60625 | CXCR2 | 3579 | 0 | 3 | 8 | |
| GSE74703 | CXCR2 | 3579 | 1 | 5 | 30 | |
| GSE74704 | CXCR2 | 3579 | 1 | 7 | 12 | |
| TCGA | CXCR2 | 3579 | 11 | 27 | 58 |
Total number of gains: 29; Total number of losses: 97; Total Number of normals: 362.
Somatic mutations of CXCR2:
Generating mutation plots.
Highly correlated genes for CXCR2:
Showing top 20/1927 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CXCR2 | SLURP1 | 0.897856 | 10 | 0 | 10 |
| CXCR2 | CYSRT1 | 0.894387 | 6 | 0 | 6 |
| CXCR2 | SPINK7 | 0.890616 | 6 | 0 | 6 |
| CXCR2 | VSIG10L | 0.888381 | 6 | 0 | 6 |
| CXCR2 | SCNN1B | 0.885751 | 10 | 0 | 10 |
| CXCR2 | PRSS27 | 0.883647 | 6 | 0 | 6 |
| CXCR2 | ECM1 | 0.882738 | 10 | 0 | 10 |
| CXCR2 | ENDOU | 0.878665 | 11 | 0 | 11 |
| CXCR2 | SCEL | 0.878038 | 10 | 0 | 10 |
| CXCR2 | SLC16A6 | 0.877465 | 11 | 0 | 11 |
| CXCR2 | CAPN14 | 0.875696 | 6 | 0 | 6 |
| CXCR2 | SPINK5 | 0.875639 | 10 | 0 | 10 |
| CXCR2 | EHD3 | 0.867682 | 11 | 0 | 11 |
| CXCR2 | ACPP | 0.866684 | 10 | 0 | 10 |
| CXCR2 | GYS2 | 0.86425 | 10 | 0 | 10 |
| CXCR2 | SFTA2 | 0.864057 | 4 | 0 | 4 |
| CXCR2 | PPL | 0.862082 | 10 | 0 | 10 |
| CXCR2 | SASH1 | 0.860391 | 11 | 0 | 11 |
| CXCR2 | RMND5B | 0.858943 | 11 | 0 | 11 |
| CXCR2 | KAT2B | 0.856649 | 11 | 0 | 11 |
For details and further investigation, click here
