| Full name: guanylate binding protein family member 6 | Alias Symbol: DKFZp686G0786 | ||
| Type: protein-coding gene | Cytoband: 1p22.2 | ||
| Entrez ID: 163351 | HGNC ID: HGNC:25395 | Ensembl Gene: ENSG00000183347 | OMIM ID: 612467 |
| Drug and gene relationship at DGIdb | |||
Expression of GBP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GBP6 | 163351 | 1559607_s_at | -2.5400 | 0.0297 | |
| GSE26886 | GBP6 | 163351 | 1559607_s_at | -4.5029 | 0.0000 | |
| GSE45670 | GBP6 | 163351 | 1559607_s_at | -1.4823 | 0.0019 | |
| GSE63941 | GBP6 | 163351 | 1559607_s_at | 1.8241 | 0.3227 | |
| GSE77861 | GBP6 | 163351 | 1559607_s_at | -2.8782 | 0.0023 | |
| GSE97050 | GBP6 | 163351 | A_23_P130642 | 0.8069 | 0.0620 | |
| SRP007169 | GBP6 | 163351 | RNAseq | -3.6743 | 0.0000 | |
| SRP008496 | GBP6 | 163351 | RNAseq | -3.1322 | 0.0000 | |
| SRP064894 | GBP6 | 163351 | RNAseq | -3.7997 | 0.0000 | |
| SRP133303 | GBP6 | 163351 | RNAseq | -3.6499 | 0.0000 | |
| SRP159526 | GBP6 | 163351 | RNAseq | -3.7094 | 0.0000 | |
| SRP193095 | GBP6 | 163351 | RNAseq | -3.3804 | 0.0000 | |
| SRP219564 | GBP6 | 163351 | RNAseq | -3.4899 | 0.0041 | |
| TCGA | GBP6 | 163351 | RNAseq | 0.9388 | 0.0031 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by GBP6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GBP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GBP6 | 163351 | 0 | 8 | 22 | |
| GSE20123 | GBP6 | 163351 | 0 | 8 | 22 | |
| GSE43470 | GBP6 | 163351 | 2 | 3 | 38 | |
| GSE46452 | GBP6 | 163351 | 1 | 1 | 57 | |
| GSE47630 | GBP6 | 163351 | 8 | 5 | 27 | |
| GSE54993 | GBP6 | 163351 | 0 | 1 | 69 | |
| GSE54994 | GBP6 | 163351 | 6 | 2 | 45 | |
| GSE60625 | GBP6 | 163351 | 0 | 0 | 11 | |
| GSE74703 | GBP6 | 163351 | 1 | 3 | 32 | |
| GSE74704 | GBP6 | 163351 | 0 | 5 | 15 | |
| TCGA | GBP6 | 163351 | 6 | 23 | 67 |
Total number of gains: 24; Total number of losses: 59; Total Number of normals: 405.
Somatic mutations of GBP6:
Generating mutation plots.
Highly correlated genes for GBP6:
Showing top 20/973 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GBP6 | CYSRT1 | 0.915417 | 4 | 0 | 4 |
| GBP6 | TTC22 | 0.906174 | 4 | 0 | 4 |
| GBP6 | GDPD3 | 0.902888 | 4 | 0 | 4 |
| GBP6 | C5orf66-AS1 | 0.889667 | 4 | 0 | 4 |
| GBP6 | ENDOU | 0.88957 | 4 | 0 | 4 |
| GBP6 | KAT2B | 0.886422 | 4 | 0 | 4 |
| GBP6 | CAPN5 | 0.885138 | 4 | 0 | 4 |
| GBP6 | SPNS2 | 0.881104 | 4 | 0 | 4 |
| GBP6 | SLC16A6 | 0.880332 | 4 | 0 | 4 |
| GBP6 | TTC9 | 0.879842 | 4 | 0 | 4 |
| GBP6 | ANXA9 | 0.875166 | 4 | 0 | 4 |
| GBP6 | EVPL | 0.874943 | 4 | 0 | 4 |
| GBP6 | IL1RN | 0.874557 | 4 | 0 | 4 |
| GBP6 | SNORA68 | 0.872326 | 4 | 0 | 4 |
| GBP6 | CAB39L | 0.86778 | 4 | 0 | 4 |
| GBP6 | PPP1R7 | 0.867516 | 4 | 0 | 4 |
| GBP6 | FAM214A | 0.865671 | 4 | 0 | 4 |
| GBP6 | FCHO2 | 0.865207 | 4 | 0 | 4 |
| GBP6 | SMIM5 | 0.863305 | 4 | 0 | 4 |
| GBP6 | GALNT12 | 0.861168 | 4 | 0 | 4 |
For details and further investigation, click here
