| Full name: atypical chemokine receptor 2 | Alias Symbol: CCR10|D6|CCR9 | ||
| Type: protein-coding gene | Cytoband: 3p22.1 | ||
| Entrez ID: 1238 | HGNC ID: HGNC:1565 | Ensembl Gene: ENSG00000144648 | OMIM ID: 602648 |
| Drug and gene relationship at DGIdb | |||
Expression of ACKR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACKR2 | 1238 | 206887_at | 0.1159 | 0.6918 | |
| GSE20347 | ACKR2 | 1238 | 206887_at | 0.0063 | 0.9397 | |
| GSE23400 | ACKR2 | 1238 | 206887_at | 0.0255 | 0.5677 | |
| GSE26886 | ACKR2 | 1238 | 206887_at | -0.1876 | 0.1151 | |
| GSE29001 | ACKR2 | 1238 | 206887_at | -0.2501 | 0.0310 | |
| GSE38129 | ACKR2 | 1238 | 206887_at | -0.0919 | 0.2347 | |
| GSE45670 | ACKR2 | 1238 | 206887_at | 0.0257 | 0.8497 | |
| GSE53622 | ACKR2 | 1238 | 76322 | -0.4711 | 0.0000 | |
| GSE53624 | ACKR2 | 1238 | 76322 | -0.4372 | 0.0000 | |
| GSE63941 | ACKR2 | 1238 | 206887_at | 0.0511 | 0.8264 | |
| GSE77861 | ACKR2 | 1238 | 206887_at | -0.0992 | 0.2455 | |
| SRP007169 | ACKR2 | 1238 | RNAseq | -0.9101 | 0.1264 | |
| SRP064894 | ACKR2 | 1238 | RNAseq | -0.6935 | 0.0070 | |
| SRP133303 | ACKR2 | 1238 | RNAseq | -0.3516 | 0.0245 | |
| SRP159526 | ACKR2 | 1238 | RNAseq | -1.6904 | 0.0002 | |
| SRP193095 | ACKR2 | 1238 | RNAseq | 0.0116 | 0.9298 | |
| SRP219564 | ACKR2 | 1238 | RNAseq | -0.4292 | 0.3024 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ACKR2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ACKR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACKR2 | 1238 | 0 | 19 | 11 | |
| GSE20123 | ACKR2 | 1238 | 0 | 19 | 11 | |
| GSE43470 | ACKR2 | 1238 | 0 | 21 | 22 | |
| GSE46452 | ACKR2 | 1238 | 2 | 17 | 40 | |
| GSE47630 | ACKR2 | 1238 | 1 | 24 | 15 | |
| GSE54993 | ACKR2 | 1238 | 7 | 2 | 61 | |
| GSE54994 | ACKR2 | 1238 | 1 | 34 | 18 | |
| GSE60625 | ACKR2 | 1238 | 5 | 0 | 6 | |
| GSE74703 | ACKR2 | 1238 | 0 | 17 | 19 | |
| GSE74704 | ACKR2 | 1238 | 0 | 13 | 7 | |
| TCGA | ACKR2 | 1238 | 1 | 71 | 24 |
Total number of gains: 17; Total number of losses: 237; Total Number of normals: 234.
Somatic mutations of ACKR2:
Generating mutation plots.
Highly correlated genes for ACKR2:
Showing top 20/454 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACKR2 | RNF17 | 0.733826 | 3 | 0 | 3 |
| ACKR2 | CHST4 | 0.726722 | 3 | 0 | 3 |
| ACKR2 | EPHA5 | 0.710306 | 5 | 0 | 4 |
| ACKR2 | HLA-DOA | 0.687325 | 3 | 0 | 3 |
| ACKR2 | CACNB1 | 0.676994 | 4 | 0 | 4 |
| ACKR2 | DAB1 | 0.669914 | 5 | 0 | 5 |
| ACKR2 | TPSG1 | 0.666344 | 4 | 0 | 4 |
| ACKR2 | CNTD2 | 0.664621 | 4 | 0 | 4 |
| ACKR2 | NCR2 | 0.661139 | 4 | 0 | 3 |
| ACKR2 | RNF185-AS1 | 0.659813 | 4 | 0 | 4 |
| ACKR2 | EFR3B | 0.659071 | 3 | 0 | 3 |
| ACKR2 | HHLA1 | 0.658537 | 4 | 0 | 3 |
| ACKR2 | APBA1 | 0.65764 | 4 | 0 | 4 |
| ACKR2 | SERINC2 | 0.656221 | 3 | 0 | 3 |
| ACKR2 | FXYD7 | 0.655554 | 4 | 0 | 4 |
| ACKR2 | KRTAP5-8 | 0.65282 | 4 | 0 | 3 |
| ACKR2 | OR3A3 | 0.652405 | 4 | 0 | 4 |
| ACKR2 | MMP25 | 0.651452 | 3 | 0 | 3 |
| ACKR2 | GDF5 | 0.649966 | 4 | 0 | 4 |
| ACKR2 | SAMD4B | 0.647344 | 3 | 0 | 3 |
For details and further investigation, click here
