| Full name: potassium voltage-gated channel subfamily E regulatory subunit 1 | Alias Symbol: minK|ISK|JLNS2|LQT5 | ||
| Type: protein-coding gene | Cytoband: 21q22.12 | ||
| Entrez ID: 3753 | HGNC ID: HGNC:6240 | Ensembl Gene: ENSG00000180509 | OMIM ID: 176261 |
| Drug and gene relationship at DGIdb | |||
KCNE1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04261 | Adrenergic signaling in cardiomyocytes |
Expression of KCNE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNE1 | 3753 | 236407_at | -0.1615 | 0.3685 | |
| GSE20347 | KCNE1 | 3753 | 208514_at | 0.0509 | 0.4804 | |
| GSE23400 | KCNE1 | 3753 | 208514_at | -0.1114 | 0.0033 | |
| GSE26886 | KCNE1 | 3753 | 208514_at | 0.2302 | 0.0794 | |
| GSE29001 | KCNE1 | 3753 | 208514_at | -0.2100 | 0.0668 | |
| GSE38129 | KCNE1 | 3753 | 208514_at | 0.0192 | 0.8550 | |
| GSE45670 | KCNE1 | 3753 | 236407_at | -0.0071 | 0.9702 | |
| GSE53622 | KCNE1 | 3753 | 33360 | -0.5130 | 0.0135 | |
| GSE53624 | KCNE1 | 3753 | 33360 | 0.1520 | 0.4199 | |
| GSE63941 | KCNE1 | 3753 | 236407_at | -1.5500 | 0.0051 | |
| GSE77861 | KCNE1 | 3753 | 208514_at | -0.0224 | 0.8895 | |
| GSE97050 | KCNE1 | 3753 | A_23_P154855 | -0.5240 | 0.2779 | |
| TCGA | KCNE1 | 3753 | RNAseq | -0.1638 | 0.6869 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KCNE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNE1 | 3753 | 2 | 7 | 21 | |
| GSE20123 | KCNE1 | 3753 | 2 | 8 | 20 | |
| GSE43470 | KCNE1 | 3753 | 1 | 11 | 31 | |
| GSE46452 | KCNE1 | 3753 | 1 | 21 | 37 | |
| GSE47630 | KCNE1 | 3753 | 6 | 17 | 17 | |
| GSE54993 | KCNE1 | 3753 | 9 | 1 | 60 | |
| GSE54994 | KCNE1 | 3753 | 1 | 9 | 43 | |
| GSE60625 | KCNE1 | 3753 | 0 | 0 | 11 | |
| GSE74703 | KCNE1 | 3753 | 1 | 8 | 27 | |
| GSE74704 | KCNE1 | 3753 | 1 | 4 | 15 | |
| TCGA | KCNE1 | 3753 | 8 | 37 | 51 |
Total number of gains: 32; Total number of losses: 123; Total Number of normals: 333.
Somatic mutations of KCNE1:
Generating mutation plots.
Highly correlated genes for KCNE1:
Showing top 20/415 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNE1 | RCAN2 | 0.721341 | 3 | 0 | 3 |
| KCNE1 | NEGR1 | 0.691906 | 4 | 0 | 3 |
| KCNE1 | IL17D | 0.683519 | 4 | 0 | 4 |
| KCNE1 | ZFP36 | 0.683441 | 3 | 0 | 3 |
| KCNE1 | ZNF582 | 0.680407 | 3 | 0 | 3 |
| KCNE1 | DACT3 | 0.672631 | 4 | 0 | 3 |
| KCNE1 | HAAO | 0.671806 | 3 | 0 | 3 |
| KCNE1 | PLIN1 | 0.670595 | 3 | 0 | 3 |
| KCNE1 | SCN4B | 0.668821 | 4 | 0 | 3 |
| KCNE1 | NLGN1 | 0.662134 | 4 | 0 | 3 |
| KCNE1 | ARC | 0.654255 | 4 | 0 | 4 |
| KCNE1 | CACNA1H | 0.653948 | 5 | 0 | 4 |
| KCNE1 | RBM24 | 0.652087 | 4 | 0 | 3 |
| KCNE1 | MYOC | 0.650689 | 3 | 0 | 3 |
| KCNE1 | MYOCD | 0.650533 | 4 | 0 | 3 |
| KCNE1 | FBXL7 | 0.647427 | 5 | 0 | 3 |
| KCNE1 | LMOD1 | 0.647298 | 4 | 0 | 3 |
| KCNE1 | ZBTB20 | 0.646377 | 3 | 0 | 3 |
| KCNE1 | LHX4 | 0.644436 | 3 | 0 | 3 |
| KCNE1 | RYR2 | 0.644343 | 5 | 0 | 4 |
For details and further investigation, click here
